Results 61 to 70 of about 4,270,323 (214)

Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C

, 1998
Receptor tyrosine kinase–mediated activation of the Raf-1 protein kinase is coupled to the small guanosine triphosphate (GTP)–binding protein Ras.
Light, Yvonne, Marais, Richard, Mason, Clive, Olson, Michael F., Paterson, Hugh, Marshall, Christopher J.   +5 more
core   +1 more source

Adaptive Cellular Responsiveness to Electrical Stimulation at the Skin‐Electrode Interface

Advanced Science, EarlyView.
This study presents an adaptive bioelectronic response in which sustained electrical stimulation (ES) upregulates voltage‐gated calcium channels (VGCCs) and enhances cellular sensitivity to subsequent ES at the skin‐device interface. VGCC‐associated adaptive sensitization promotes regenerative wound‐healing responses in vivo, including accelerated ...
Yeon Jae Chang, Soon Jin Choi, Khandoker Asiqur Rahaman, Tae Kyoung Lee, Gwangbin Lee, Jaeyeon Jun, Hyeon‐Jeong Lee, Hophil Min, Hojeong Jeon, Jung Keun Hyun, Hyung‐Seop Han, Jimin Park   +11 more
wiley   +1 more source

Current Status of Raf Kinase Inhibitor Protein (RKIP) in Lung Cancer: Behind RTK Signaling

Cells, 2019
Lung cancer is the most deadly neoplasm with the highest incidence in both genders, with non-small cell lung cancer (NSCLC) being the most frequent subtype. Somatic mutations within the tyrosine kinase domain of the epidermal growth factor receptor (EGFR)
Ana Raquel-Cunha, Diana Cardoso-Carneiro, Rui M. Reis, Olga Martinho   +3 more
doaj   +1 more source

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

American Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse   +16 more
wiley   +1 more source

Expression of raf kinase inhibitor protein is down regulated in response to newcastle disease virus infection to promote viral replication.

, 2015
Newcastle disease virus (NDV) causes a severe and economically significant disease affecting almost the entire poultry industry worldwide. However, factors that affect NDV replication in host cells are poorly understood.
Xu, R., Yin, R., Zhang, P., Stöger, T., Ding, Z., Liu, X., Ai, L., Xie, G., Sun, Y., Bi, Y., Meng, X.   +10 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source

Progresses in the structure and biological function of Raf kinase inhibitory protein [PDF]

, 2013
rAf激酶抑制蛋白(rAf kInASE InHIbITOry PrOTEIn,rkIP)属于磷脂酰乙醇胺结合蛋白(PHOSPHATIdy-lETHAnOlAMInE bIndIng PrOTEIn,PEbP)家族,参与多种生理过程,可以交叉调控MAPk(MITOgEn-ACTIVATEdPrOTEIn kInASE)通路、gPCr(g-PrOTEIn-COuPlEd rECEPTOr)通路和nf-κb(nuClEAr fACTOr-κb)信号通路。细胞信号转导通路的异常会促进肿瘤的发生与发展 ...
吴智华, 郭晨云
core  

Expression of Raf Kinase Inhibitor Protein (RKIP) is a predictor of uveal melanoma metastasis [PDF]

, 2014
Melanoma arising from melanocytes within the choroid is the most frequent primary intraocular neoplasm in adults. It is biologically distinct from cutaneous melanoma by a very strong propensity to metastasize the liver.
Caltabiano, Rosario, Cardile, Venera, Barresi, Valeria, RAGUSA, MARCO, Puzzo, Lidia, Longo, Antonio, Loreto, Carla, Reibaldi, Michele, RUSSO, ANDREA, LORETO, CARLA AGATA, Barresi V, Russo A   +11 more
core   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source