Results 41 to 50 of about 454,799 (340)
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Independent living program evaluation for Rebuilding All Goals Efficiently
, 2011 This paper evaluates the outcome of independent living (IL) services provided to clients with Spinal Cord Injuries (SCI) by a local non-profit organization, Rebuilding All Goals Efficiently (RAGE).
Armour, Patricia +2 more
core +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Frontiers in Molecular NeuroscienceOne of the hallmarks of Alzheimer's disease (AD) is the accumulation of beta-amyloid peptide (Aβ) leading to formation of soluble neurotoxic Aβ oligomers and insoluble amyloid plaques in various parts of the brain.
Kseniya B. Varshavskaya +4 more
doaj +1 more source
Drivers’ behaviour modelling for virtual worlds [PDF]
, 2013 In this paper we present a study that looks at modelling drivers’ behaviour with a view to contribute to the problem of road rage. The approach we adopt is based on agent technology, particularly multi-agent systems.
Bechkoum, Kamal +2 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu +5 more
wiley +1 more source
A many-body RAGE theorem [PDF]
, 2015 We prove a generalized version of the RAGE theorem for N-body quantum systems. The result states that only bound states of systems with $0\leq n\leq N$ particles persist in the long time average.
Lampart, Jonas, Lewin, Mathieu
core +2 more sources
Rheocasting versus Die Casting: An Insight into the Low‐Cycle Fatigue Behavior of AlSi7Mg0.6
Advanced Engineering Materials, EarlyView.The study compares rheocast lightweight components with high‐pressure die cast materials regarding microstructure and fatigue behavior. Rheocast process offers higher efficiency due to lower casting temperatures. Despite some microstructural differences, both processes show similar strengths (yield strength 125 MPa, tensile strength 240 MPa).
Julia Richter +4 more
wiley +1 more source
G82S RAGE polymorphism is associated with Alzheimer’s disease
Frontiers in Bioscience-Elite, 2020 Receptor for advanced glycation end products (RAGE) has been implicated in the pathophysiology of Alzheimer’s disease (AD) due to its ability to interact with amyloid beta and to elicit an inflammatory response. sRAGE, one of the splice variants of RAGE,
Rani Cathrine Chellappa +1 more
doaj +1 more source