Results 61 to 70 of about 21,216 (279)

Influence of Sex/Gender and Race on Responses to Raltegravir Combined With Tenofovir-Emtricitabine in Treatment-Naive Human Immunodeficiency Virus-1 Infected Patients: Pooled Analyses of the STARTMRK and QDMRK Studies. [PDF]

, 2017
BACKGROUND: Antiretroviral therapy in human immunodeficiency virus (HIV)-infected women and blacks merits particular scrutiny because these groups have been underrepresented in clinical trials.
Bekker, Linda-Gail, DiNubile, Mark J, Katlama, Christine, Leavitt, Randi Y, Rodgers, Anthony J, Sklar, Peter A, Squires, Kathleen E., Teppler, Hedy, Yazdanpanah, Yazdan, Zhou, Yan   +9 more
core   +2 more sources

Raltegravir-Induced Adaptations of the HIV-1 Integrase: Analysis of Structure, Variability, and Mutation Co-occurrence

Frontiers in Microbiology, 2019
The human immunodeficiency virus type 1 (HIV-1) has several proteins of therapeutic importance, many of which are currently used as drug targets in antiretroviral therapy. Among these proteins is the integrase, which is responsible for the integration of
Lucas de Almeida Machado, Marcelo Ferreira da Costa Gomes, Ana Carolina Ramos Guimarães   +2 more
doaj   +1 more source

Cross-resistance to elvitegravir and dolutegravir in 502 patients failing on raltegravir: a French national study of raltegravir-experienced HIV-1-infected patients [PDF]

, 2015
OBJECTIVES: The objectives of this study were to determine the prevalence and patterns of resistance to integrase strand transfer inhibitors (INSTIs) in patients experiencing virological failure on raltegravir-based ART and the impact on susceptibility ...
A. Maillard, A. Mirand, A. Rodallec, A. Signori-Schmuck, A.G. Marcelin, ANRS AC11 Resistance Study Group, B. Montes, C. Amiel, C. Charpentier, C. Delaugerre, D. Bettinger, D. Descamps, F. Barin, F. Nicot, H. Jeulin, H. Le Guillou-Guillemette, L. Morand-Joubert, M.A. Trabaud, P. Flandre, S. Fourati, S. Reigadas, S. Vallet, V. Calvez   +22 more
core   +4 more sources

Pharmacokinetics and Safety of a Raltegravir-Containing Regimen in Children Aged 4 Weeks to 2 Years Living With Human Immunodeficiency Virus and Receiving Rifampin for Tuberculosis.

Journal of the Pediatric Infectious Diseases Society, 2020
Pharmacological interactions limit treatment options for children living with human immunodeficiency virus (HIV) and tuberculosis (TB). We found that 12 mg/kg twice daily raltegravir chewable tablets (administered after crushing) safely achieved ...
P. Krogstad, P. Samson, E. Acosta, J. Moye, Ellen Townley, Sarah Bradford, E. Brown, Kayla Denson, B. Graham, L. Hovind, Thucuma Sise, H. Teppler, S. R. Mathiba, L. Fairlie, J. Winckler, G. Slade, T. Meyers   +16 more
semanticscholar   +1 more source

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, EarlyView.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

Efficacy and Safety of Raltegravir-Based Dual Therapy in AIDS Patients: A Meta-Analysis of Randomized Controlled Trials

Frontiers in Pharmacology, 2019
Background: The life expectancy for HIV-infected individuals has improved dramatically because of improvements in antiretroviral therapy (ART). Today, a simplified two-drug regimen enhances adherence and treatment satisfaction by reducing adverse effects.
Yinqiu Huang, Yinqiu Huang, Xiaojie Huang, Hui Chen, Hao Wu, Yaokai Chen, Yaokai Chen   +6 more
doaj   +1 more source

Rhabdomyolysis in an HIV cohort: epidemiology, causes and outcomes. [PDF]

, 2017
BackgroundThe Literature on rhabdomyolysis in the HIV-positive population is sparse and limited. We aimed to explore the incidence, patient characteristics, etiologies and outcomes of rhabdomyolysis in a cohort of HIV-positive patients identified through
Atta, Mohamed G, Estrella, Michelle M, Fine, Derek M, Koubar, Sahar H, Lucas, Gregory M, Moore, Richard D, Warrier, Rugmini   +6 more
core   +1 more source

Raltegravir use and outcomes among children and adolescents living with HIV in the IeDEA global consortium

Journal of the International AIDS Society, 2020
As integrase inhibitors become available in low‐ and middle‐income countries (LMICs), they offer the potential to expand extremely limited treatment options available to children and adolescents.
G. Patten, T. Puthanakit, C. McGowan, K. Wools-Kaloustian, R. Hazra, J. Pinto, D. Machado, R. Succi, A. Sohn, H. Rabie, B. Musick, M. Davies   +11 more
semanticscholar   +1 more source

A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV

PLoS ONE, 2020
Objective Optimization of antiretroviral therapy and anti-inflammatory treatments, such as statins, are among the strategies aimed at reducing metabolic disorders, inflammation and immune activation in people living with HIV (PLWH).
E. Negredo, Montse Jiménez, J. Puig, C. Loste, N. Pérez-Álvarez, V. Urrea, P. Echeverría, A. Bonjoch, B. Clotet, J. Blanco   +9 more
semanticscholar   +1 more source

HPV42 – a human papillomavirus classified as a low‐risk type with oncogenic potential

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Human papillomavirus (HPV) type 42 is a rare HPV type currently classified as “low‐risk” and belongs to the alpha genus. It has primarily been detected in benign vulvar papillomas and is predominantly associated with benign lesions such as anogenital warts.
Sven Niklas Burmann, Ulrike Wieland, Steffi Silling, Frank Oellig, David Chromy, Julia Hyun, Thilo Gambichler, Alexander Kreuter   +7 more
wiley   +1 more source