Results 61 to 70 of about 12,405 (251)

A phase IV, open-label three-arm study investigating the impact of a combination of tenofovir disoproxil fumarate/emtricitabine with raltegravir or dolutegravir or elvitegravir/cobicistat on renal function in HIV-1 antiretroviral naïve patients

HIV Research & Clinical Practice, 2021
Objectives: Tenofovir DF (TDF) remains one of the preferred backbone agents for naïve HIV patients starting antiretroviral treatment (ART). The impact of TDF on renal function and metabolic parameters may vary by anchor agent.
Margherita Bracchi, Nicole Pagani, Alessia Dalla Pria, Ana Milinkovic, Nneka Nwokolo, Lervina Thomas, Sundhyia Mandalia, Marta Boffito, Graeme Moyle   +8 more
doaj   +1 more source

Body Composition Changes After Initiation of Raltegravir or Protease Inhibitors: ACTG A5260s.

Clinical Infectious Diseases, 2016
BACKGROUND Fat gain after antiretroviral therapy (ART) occurs, and its association with protease inhibitors (PIs) is unclear. METHODS Peripheral and central fat depots and lean mass were measured using standardized and centrally read abdominal CT scans
G. McComsey, C. Moser, J. Currier, H. Ribaudo, Pawel Paczuski, M. Dubé, T. Kelesidis, Jennifer Rothenberg, J. Stein, T. Brown   +9 more
semanticscholar   +1 more source

Effect of Pregnancy on Unbound Raltegravir Concentrations in the ANRS 160 RalFe Trial

Antimicrobial Agents and Chemotherapy, 2020
A population pharmacokinetic model was developed to explore the pharmacokinetics modification of unbound raltegravir during pregnancy. The RalFe ANRS160 study was a nonrandomized, open-label, multicenter trial enrolling HIV-infected pregnant women ...
Yi Zheng, D. Hirt, Sandrine Delmas, Gabrielle Lui, S. Benaboud, Jerome Lechedanec, J. Treluyer, C. Chenevier-Gobeaux, Elisa Arezes, A. Gelley, I. Amri, S. Urien, N. Bouazza, F. Foissac, J. Warszawski, J. Ghosn   +15 more
semanticscholar   +1 more source

DRESS syndrome associated with raltegravir

Dermatology Online Journal, 2011
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity is a potentially life-threatening drug hypersensitivity syndrome most commonly associated with anticonvulsants, allopurinol, long-acting sulfonamides, dapsone, and minocycline.
Zhang, Kevin S, Modi, Gunjan M, Hsu, Sylvia   +2 more
openaire   +4 more sources

Factors mediating and associated with immunological response in women living with HIV in Sweden: A nationwide register‐based study

HIV Medicine, EarlyView.
Abstract Introduction Women remain underrepresented in studies on immunological response (IR) among virally suppressed people living with HIV. Despite receiving antiretroviral therapy (ART) some individuals do not attain an IR, increasing their risk of non‐AIDS morbidity and mortality.
Josefin Nilsson, Olof Elvstam, Erik Sörstedt, Philippe Wagner, Piotr Nowak, Johanna Brännström, Christina Carlander   +6 more
wiley   +1 more source

Raltegravir

Reactions weekly, 2020
A small molecule with activity against human immunodeficiency virus (HIV). Raltegravir is an integrase inhibitor that blocks the integration of the viral genome into the host DNA, a critical step in the pathogenesis of HIV.
DE Hoja, Datos DE Seguridad
semanticscholar   +1 more source

Antiretroviral therapy use, self‐reported adherence, and viral suppression among women living with HIV in Canada

HIV Medicine, Volume 26, Issue 7, Page 1060-1073, July 2025.
Abstract Background Traditionally, ≥95% adherence was recommended for viral suppression (VS). Newer antiretroviral therapy (ART) is now being increasingly prescribed and may be more forgiving of lower adherence. The lifelong nature of ART presents adherence challenges, particularly for women living with HIV. We aimed to describe ART use and examine the
Maysaloun Mokaddam, Nadine Kronfli, Nancy L. Sheehan, Araceli Gonzalez Reyes, Danièle Dubuc, Mona Loutfy, Angela Kaida, Alexandra de Pokomandy, on behalf of the CHIWOS research team, Rahma Abdul‐Noor, Aranka Anema, Jonathan Angel, Dada Mamvula Bakombo, Fatimatou Barry, Greta Bauer, Kerrigan Beaver, Marc Boucher, Isabelle Boucoiran, Jason Brophy, Lori Brotto, Ann N. Burchell, Claudette Cardinal, Allison Carter, Lynne Cioppa, Tracey Conway, José Côté, Jasmine Cotnam, Cori d'Ambrumenil, Janice Dayle, Erin Ding, Danièle Dubuc, Janice Duddy, Mylène Fernet, Annette Fraleigh, Peggy Frank, Brenda Gagnier, Marilou Gagnon, Jacqueline Gahagan, Claudine Gasingirwa, Nada Gataric, Rebecca Gormley, Saara Greene, Danielle Groleau, Charlotte Guerlotté, Trevor Hart, Catherine Hankins, Emily Heer, Robert S. Hogg, Terry Howard, Shazia Islam, Joseph Jean‐Gilles, Hermione Jefferis, Evin Jones, Charu Kaushic, Mina Kazemi, Mary Kestler, Maxime Kiboyogo, Marina Klein, Nadine Kronfli, Gladys Kwaramba, Gary Lacasse, Ashley Lacombe‐Duncan, Melanie Lee, Rebecca Lee, Jenny Li, Viviane Lima, Elisa Lloyd‐Smith, Carmen Logie, Evelyn Maan, Valérie Martel‐Lafrenière, Carrie Martin, Renee Masching, Lyne Massie, Melissa Medjuck, Brigitte Ménard, Cari L. Miller, Judy Mitchell, Gerardo Mondragon, Deborah Money, Ken Monteith, Marvelous Muchenje, Florida Mukandamutsa, Mary Ndung'u, Valerie Nicholson, Kelly O'Brien, Nadia O'Brien, Gina Ogilvie, Susanna Ogunnaike‐Cooke, Joanne Otis, Rebeccah Parry, Sophie Patterson, Angela Paul, Doris Peltier, Neora Pick, Alie Pierre, Jeff Powis, Karène Proulx‐Boucher, Corinna Quan, Jesleen Rana, Eric Roth, Danielle Rouleau, Geneviève Rouleau, Sergio Rueda, Kate Salters, Margarite Sanchez, Roger Sandre, Jacquie Sas, Édénia Savoie, Paul Sereda, Stephanie Smith, Marcie Summers, Wangari Tharao, Christina Tom, Cécile Tremblay, Jason Trigg, Sylvie Trottier, Angela Underhill, Anne Wagner, Sharon Walmsley, Clara Wang, Kath Webster, Wendy Wobeser, Denise Wozniak, Mark H. Yudin, Wendy Zhang, Julia Zhu   +125 more
wiley   +1 more source

Synthesis and Biological Assessment of Cyanopyridine‐Based 1,3,4‐Oxadiazole Derivatives: Anticancer Potential, Antioxidant Activity, Molecular Docking, and DFT Calculations

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
A series of novel cyanopyridine‐based 1,3,4‐oxadiazole derivatives were synthesized, and their anticancer activities against the MCF‐7 and CaCo‐2 cancer cell lines, as well as their antioxidant capacities, were evaluated under In Vitro conditions. Furthermore, computational studies utilizing Density Functional Theory (DFT) and molecular modeling were ...
Zineddine Zebbiche, Güldeniz Şekerci, Boulebd Houssem, Fatümetüzzehra Küçükbay, Suat Tekin, Hasan Küçükbay, Boudjemaa Boumoud   +6 more
wiley   +1 more source

Evolution of raltegravir resistance during therapy [PDF]

Journal of Antimicrobial Chemotherapy, 2009
We investigated the prevalence of raltegravir resistance-associated mutations at baseline and their evolution during raltegravir therapy in patients infected with different HIV-1 subtypes.At pre-treatment screening, the integrase gene from plasma samples from patients infected with subtype B and non-B viruses was analysed.
Gerd Fätkenheuer, Martin Däumer, Saleta Sierra, Eugen Schülter, Rolf Kaiser, Nadine Sichtig, Andre Altmann, Stefan Reuter, Ulf Dittmer, Herbert Pfister, Stefan Esser   +10 more
openaire   +3 more sources

Modelling the impact of initiation delay, duration and prior PrEP on the efficacy of post‐exposure prophylaxis containing a tenofovir/emtricitabine backbone

Journal of the International AIDS Society, Volume 28, Issue S1, 25 June.
Abstract Introduction Pre‐ and post‐exposure prophylaxis (PrEP and PEP) are important pillars of the HIV prevention portfolio to reduce the risk of acquisition just before or after HIV exposure. While PrEP efficacy has been elucidated in many randomized clinical trials, corresponding data for PEP is extremely difficult to obtain in a controlled setting.
Lanxin Zhang, Simon Collins, Julie Fox, Max von Kleist   +3 more
wiley   +1 more source