Results 61 to 70 of about 1,927 (159)
Infectious Disease Reports, 2017 We conducted a retrospective study in a general hospital in Buenos Aires, Argentina (2009-2015) aimed at evaluating outcomes in HIV-infected pregnant women (HIPW), who were prescribed raltegravir (RAL)- containing antiretroviral therapy (ART). A total of
Diego M. Cecchini +3 more
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Journal of Chemistry, Volume 2025, Issue 1, 2025.Antibiotic resistance represents a significant public health challenge in the current century. The β‐lactam antibiotics, together with carbapenems, are inactivated by zinc‐dependent bacterial enzymes called metallo‐β‐lactamases (MBLs). Presently there are no clinically permitted MBL inhibitors, and to produce such drugs, it is indispensable to ...
Shivakumara K. N. +7 more
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Progress of ADAM17 in Fibrosis‐Related Diseases
Mediators of Inflammation, Volume 2025, Issue 1, 2025.Fibrosis leads to structural damage and functional decline and is characterized by an accumulation of fibrous connective tissue and a reduction in parenchymal cells. Because of its extremely poor prognosis, organ fibrosis poses a significant economic burden.
Suyan Yan +7 more
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Brief Histories of Retroviral Integration Research and Associated International Conferences
VirusesThe field of retroviral integration research has a long history that started with the provirus hypothesis and subsequent discoveries of the retroviral reverse transcriptase and integrase enzymes.
Duane P. Grandgenett, Alan N. Engelman
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Retrovirology, 2011 Background HIV-2 is endemic in West Africa and has spread throughout Europe. However, the alternatives for HIV-2-infected patients are more limited than for HIV-1.
Damond Florence +7 more
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An Electrosynthesis of 1,3,4‐Oxadiazoles from N‐Acyl Hydrazones
Chemistry – A European Journal, Volume 30, Issue 69, December 10, 2024.The indirect electrochemical oxidative cyclisation of N‐acyl hydrazones offers an efficient approach to access 1,3,4‐oxadiazoles, an important motif in medicinal chemistry. The DABCO‐mediated reaction enables the selective synthesis of a broad range of these valuable heterocycles from readily available aldehydes and hydrazides.
Luke Chen +2 more
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Raltegravir: molecular basis of its mechanism of action
European Journal of Medical Research, 2009 Integration of the HIV-1 viral DNA generated by reverse transcription of the RNA genome into the host cell chromosomes is a key step of viral replication, catalyzed by the viral integrase.
Mouscadet Jean-François +1 more
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Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence
Viruses, 2015 Drug resistance prevents the successful treatment of HIV-positive individuals by decreasing viral sensitivity to a drug or a class of drugs. In addition to transmitted resistant viruses, treatment-naïve individuals can be confronted with the problem of ...
Thibault Mesplède, Mark A. Wainberg
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Global & Regional Health Technology Assessment, 2017 Budget impact analysis in the maintenance raltegravir-containing regimen in virologically suppressed HIV infected patientsBackgroundA one-year cost analysis was conducted to estimate the impact from the perspective of the Italian National Health Service (
Roberto Ravasio +3 more
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Journal of Virus Eradication, 2015 Background: It is unclear whether intensification of standard highly active antiretroviral therapy (HAART) with entry and integrase inhibitors during acute HIV infection (AHI) could yield greater benefits in reducing markers for HIV reservoir size and ...
Jintanat Ananworanich +16 more
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