Results 91 to 100 of about 48,769 (198)

In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity

Translational Oncology, 2019
Ovarian cancer is the second most common gynecological malignancy worldwide. Paclitaxel is particularly important in the therapy of ovarian carcinomas, but the treatment efficacy is counteracted by the development of resistance to chemotherapy.
Lucia D'Antona, Vincenzo Dattilo, Giada Catalogna, Domenica Scumaci, Claudia Vincenza Fiumara, Francesca Musumeci, Giuseppe Perrotti, Silvia Schenone, Rossana Tallerico, Cristina B. Spoleti, Nicola Costa, Rodolfo Iuliano, Giovanni Cuda, Rosario Amato, Nicola Perrotti   +14 more
doaj  

The Acidic Domains of the Toc159 Chloroplast Preprotein Receptor Family are Instrinsically Disordered Protein Domains [PDF]

, 2009
Background: The Toc159 family of proteins serve as receptors for chloroplast-destined preproteins. They directly bind to transit peptides, and exhibit preprotein substrate selectivity conferred by an unknown mechanism.
Jelokhani-Niaraki, Masoud, Richardson, Lynn G.L., Smith, Matthew D.   +2 more
core   +1 more source

Extreme multivalency and a composite short linear motif facilitate PCNA‐binding, localisation and abundance of p21 (CDKN1A)

The FEBS Journal, EarlyView.
Regions flanking the PCNA‐binding motif in p21 contribute to high‐affinity binding through complementary charges without specific contacts. These regions affect p21 abundance, but their exact Lys/Arg composition is unimportant for PCNA binding. Conversely, both context and Lys/Arg composition of the N‐terminal flanking region are crucial for p21 ...
Signe Simonsen, Fia B. Larsen, Caroline K. Søgaard, Nicolas Jonsson, Kresten Lindorff‐Larsen, Per Bruheim, Marit Otterlei, Rasmus Hartmann‐Petersen, Birthe B. Kragelund   +8 more
wiley   +1 more source

Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor [PDF]

, 1997
NLS proteins are transported into the nucleus by the importin α/β heterodimer. Importin α binds the NLS, while importin β mediates translocation through the nuclear pore complex.
Bischoff, F.Ralf, Görlich, Dirk, Kostka, Susanne, Kraft, Regine, Kutay, Ulrike   +4 more
core   +1 more source

Late blight pathogen targets host Rab‐G3 GTPases with an atypical GTPase‐activating protein

Journal of Integrative Plant Biology, EarlyView.
The Phytophthora infestans RXLR effector Pi17063 functions as an atypical GTPase‐activating protein of host positive immune regulators, specifically the small GTPase NbRab‐G3. Pi17063 promotes the relocalization of NbRab‐G3 proteins to the cytoplasm, where they are inactive, disrupting the balance of the NbRab‐G3 switch and thus leading to enhanced ...
Song Liu, Liwen Ding, Xiong Liu, Xiaoxi Xing, Jinyang Li, Tiantian Yan, Yuli Huang, Yuan Liu, Yisa Wang, Xia Zhang, Zeming Liu, Xiyu Cao, Yuling Meng, Weixing Shan   +13 more
wiley   +1 more source

Tolerance to Phosphorus Deficiency Improves Seed Phytic Acid‐to‐Iron Molar Ratios in Common Bean

Plant, Cell &Environment, EarlyView.
ABSTRACT Although significant advances have been achieved in the biofortification of common beans to overcome deficiencies in Zinc (Zn) and iron (Fe), the mechanisms involved remain poorly understood. We thus explored the relationships between phosphorus nutrition and Zn and Fe accumulation in four bean genotypes (Edar, Nizok, Colorado and Chimbolos ...
Barbara Karpinska, Christine H. Foyer
wiley   +1 more source

The mood stabilizers lithium and valproate disrupt hepatic and intestinal farnesoid X receptor signalling and increase bile synthesis in the rat

Experimental Physiology, EarlyView.
Abstract The mood stabilizers lithium and valproate are psychotropic medications widely used in clinical practice. Despite their proven benefits, many individuals stop their treatment due to the adverse effects. Chronic diarrhoea is a common reason for discontinuation of these drugs; however, the underlying mechanisms are unknown.
Sofia Cussotto, Anna V. Golubeva, Alvaro Lopez Gallardo, Thomaz F. S. Bastiaanssen, Alexander V. Zhdanov, Gerard M. Moloney, Caitriona Scaife, Jane A. English, Susan A. Joyce, Timothy G. Dinan, John F. Cryan   +10 more
wiley   +1 more source

Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short‐term plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Neurotransmitter release was characterized at post‐hearing rat calyx of Held synapses, before and after pharmacologically augmenting synaptic strength, by recording unitary EPSCs, or capacitance changes in response to presynaptic step depolarizations.
Kun‐Han Lin, Mrinalini Ranjan, Noa Lipstein, Nils Brose, Erwin Neher, Holger Taschenberger   +5 more
wiley   +1 more source

Potassium‐Dependent Coupling of Retinal Astrocyte Light Response to Müller Glia

Glia, Volume 73, Issue 7, Page 1520-1534, July 2025.
Main Points Astrocytes depolarize to light ON and OFF like Müller glia. The astrocyte light response is due to potassium influx. Retinal macroglial current‐voltage responses exhibit rectification which changes with repeated stimulation. ABSTRACT Astrocytes throughout the central nervous system mediate a variety of functions to support proper tissue ...
Joseph Matthew Holden, Andrew M. Boal, Lauren Katie Wareham, David John Calkins   +3 more
wiley   +1 more source

Deletion of GhSCY2D Causes Impaired Chloroplast Development and Temperature‐Dependent Leaf Yellowing in Cotton (Gossypium hirsutum L.)

Plant, Cell &Environment, Volume 48, Issue 7, Page 4902-4917, July 2025.
ABSTRACT Leaf colour mutants play an important role in understanding chlorophyll metabolism and photosynthesis. In this study, we characterised a temperature‐sensitive yellow leaf cotton mutant. Genome re‐sequencing and comparison identified a 10.327 Kb deletion on the D12 chromosome (D12:670726‐681053) in the mutant.
Xiaokang Feng, Yanmei Ma, Qian Liang, Yanlong Jin, Xuefeng Wang, Jianhang Wang, Feng Liu, Xinyu Zhang, Dongnan Shao, Jie Sun, Qian‐Hao Zhu, Fei Xue   +11 more
wiley   +1 more source