Results 51 to 60 of about 48,769 (198)

Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle [PDF]

, 2017
The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is a sequence-specific DNA binding protein which plays an essential role in viral episome replication and segregation, by recruiting the cellular complex of DNA replication onto the origin (oriP) and
Baillie, George S., Deschamps, Thibaut, Gruffat, Henri, Leske, Derek M., Lotteau, Vincent, MacLeod, Ruth, Manet, Evelyne, Maréchal, Vincent, Mompelat, Dimitri, Quentin, Bazot, Tafforeau, Lionel, Wilson, Joanna B.   +11 more
core   +2 more sources

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone. [PDF]

, 2019
We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface.
Brautigam, Chad A, Cagatay, Tolga, Chook, Yuh Min, D'Arcy, Sheena, Jiou, Jenny, Kim, Seung Joong, Padavannil, Abhilash, Sali, Andrej, Sarkar, Prithwijit, Tomchick, Diana R   +9 more
core   +1 more source

A Supramolecular Material for Controlling Kiwifruit Bacterial Canker

Advanced Science, EarlyView.
The matrine‐5‐methylsalicylic acid salt (MOS) is reported for its excellent antibacterial activity against Pseudomonas syringae pv. actinidiae (Psa), with advanced cell membrane penetration ability and strong affinities for potential targets. Furthermore, a nanosupramolecular delivery system MOS@hydroxypropyl‐beta‐cyclodextrin (HPCD) with improved ...
Xile Deng, Qiang Bian, Mingqing Zhou, Le Xie, Jichuan Zhang, Tianqi Liu, Yizhuo Zhang, Li Zhang, Jiaheng Zhang, Lianyang Bai   +9 more
wiley   +1 more source

Interface analysis of small GTP binding protein complexes suggests preferred membrane orientations

Biological chemistry, 2017
Crystal structures of small GTP binding protein complexes with their effectors and regulators reveal that one particularly flat side of the G domain that contains helix α4 and the C-terminal helix α5 is practically devoid of contacts.
I. Vetter
semanticscholar   +1 more source

Nucleocytoplasmic transport: a thermodynamic mechanism

, 2009
The nuclear pore supports molecular communication between cytoplasm and nucleus in eukaryotic cells. Selective transport of proteins is mediated by soluble receptors, whose regulation by the small GTPase Ran leads to cargo accumulation in, or depletion ...
Adam SA, Akey CW, Alber F, Bapteste E, Beck M, Becskei A, Ben‐Efraim I, Bickel T, Caspi Y, Catimel B, Cingolani G, Coppey M, Costa M, Cronshaw JM, Dange T, Denning DP, Devos D, Dixon M, Fanara P, Fradin C, Fradin C, Frey S, Grünwald D, Görlich D, Haldane JBS, Harreman MT, Henderson GP, Hinshaw JE, Hodel AE, Hu W, Hübner S, Jovanovic‐Talisman T, Kalab P, Kalderon D, Kapon R, Kobe B, Kopito RB, Kose S, Kotera I, Kubitscheck U, Kustanovich T, Köhler M, Lam MH, Lee SJ, Lyman SK, Mans BJ, Melcák I, Michael Elbaum, Michael WM, Miyamoto Y, Nachury MV, Naim B, Nakielny S, Newmeyer DD, Ossareh‐Nazari B, Pederson T, Pollard VW, Pyhtila B, Ribbeck K, Ribbeck K, Riddick G, Riddick G, Rihs HP, Robbins J, Ronen Benjamine Kopito, Rout MP, Salman H, Schmidt‐Zachmann MS, Schwartz TU, Shah S, Smith A, Stade K, Steggerda SM, Stein WD, Stoffler D, Strawn LA, Timney BL, Tokunaga M, Wen W, Yang Q, Yang W, Yang W, Zeitler B, Zilman A   +83 more
core   +2 more sources

A Thiazole Orange Derivative Targeting the Bacterial Protein FtsZ Shows Potent Antibacterial Activity. [PDF]

, 2017
The prevalence of multidrug resistance among clinically significant bacteria calls for the urgent development of new antibiotics with novel mechanisms of action.
Abagyan, Ruben, Chan, Fung-Yi, Du, Ruo-Lan, Leung, Yun-Chung, Lu, Yu-Jing, So, Lok-Yan, Sun, Ning, Wong, Kwok-Yin, Zhang, Kun, Zheng, Yuan-Yuan, Zhuo, Chao   +10 more
core   +2 more sources

Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture

Advanced Science, EarlyView.
This study uses experiments and biophysical modeling to examine the response and adaptation of cells to nanoscale topography of surfaces. It is shown that cytoskeletal assembly and nuclear localization of transcription regulatory factors such as yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) can be tuned by ...
Emmet A. Francis, Einollah Sarikhani, Vrund Patel, Dhivya Pushpa Meganathan, Leah Sadr, Anum Tahir, Zeinab Jahed, Padmini Rangamani   +7 more
wiley   +1 more source

SPARC Controls Melanoma Cell Plasticity through Rac1. [PDF]

, 2015
Cell transition to a more aggressive mesenchymal-like phenotype is a hallmark of cancer progression that involves different steps and requires tightly regulated cell plasticity.
Alvarez, Mariano J., Chuluyan, Hector Eduardo, Leishman, Claudia C., Lutzky, Viviana P., Podhajcer, Osvaldo Luis, Rivas Baquero, Elvia Carolina, Salvatierra Colussi, Edgardo Enrique   +6 more
core   +3 more sources

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33

, 2011
GTPases act as molecular switches to control many cellular processes, including signalling, protein translation and targeting. Switch activity can be regulated by external effector proteins or intrinsic properties, such as dimerization.
Anja Höfle, Aronsson, Becker, Bos, Bourne, Chen, Chen, Danny J. Schnell, Egea, Enrico Schleiff, Fei Wang, Gasper, Ingmundson, Irmgard Sinning, Ivo Tews, Jarvis, Jelic, Jelic, Kessler, Kikuchi, Koenig, Koenig, Kouranov, Lee, Machner, Maik S. Sommer, Meyer, Mislav Oreb, Neher, Oreb, Oreb, Patrick Koenig, Rapoport, Reddick, Scheffzek, Schleiff, Schleiff, Schleiff, Schnell, Sommer, Sun, Sveshnikova, Weibel, Wickner, Yeh, Zheng   +45 more
core   +3 more sources