Results 81 to 90 of about 48,769 (198)

Polymeric Giant Unilamellar Vesicles Support Longevity of Native Nuclei in Protocells

Small Science, EarlyView.
Native nuclei are isolated and incorporated into polymeric giant unilamellar vesicles (pGUVs) using microfluidics. Nucleated pGUVs retain nuclear integrity and function, providing a new platform to study the import process of peptide‐based multicompartment micelles via nuclear localization signals. This bottom‐up chimeric system lays the groundwork for
Lukas Heuberger, Arianna Balestri, Shabnam Tarvirdipour, Larisa E. Kapinos, Roderick Y. H. Lim, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan   +7 more
wiley   +1 more source

The Ran GTPase: Theme and Variations [PDF]

, 2002
The small GTPase Ran has roles in multiple cellular processes, including nuclear transport, mitotic spindle assembly, the regulation of cell cycle progression and nuclear assembly.
Dasso, Mary
core   +1 more source

Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection

Insect Science, EarlyView.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form a well‐known hybrid zone (HZ) in the Pyrenees mountain range; the Iberian endemism C. p. erythropus (Cpe) and the subspecies C. p. parallelus, (Cpp) widely distributed throughout the rest of Europe. Both subspecies differ in diverse traits, including the strains of
Patricia Jiménez‐Florido, Mónica Aquilino, David Buckley, José L. Bella, Rosario Planelló   +4 more
wiley   +1 more source

Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

Cell Proliferation, EarlyView.
This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour, Rakesh Kumar Majhi, Frode A. Norheim, Christian A. Drevon   +3 more
wiley   +1 more source

Nuclear transport: what a kary-on! [PDF]

, 1999
Compartmentalisation in eukaryotic cells presents special problems in macromolecular transport. Here we use the recently determined X-ray structures of a number of components of the nuclear transport machinery as a framework to review current ...
Gamblin, Steven J, Smerdon, Stephen J
core   +1 more source

Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development

The FEBS Journal, EarlyView.
Three skeletal muscle diseases are linked to HMGCR, a key enzyme in cholesterol synthesis. These diseases include a muscular dystrophy associated with pathogenic variants in the HMGCR gene, statin‐associated myopathy, and autoimmune anti‐HMGCR myopathy.
Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner, Gloriana Campos, Sree Venigalla, Elicia A. Estrella, Partha S. Ghosh, Audrey L. Daugherty, Seth A. Stafki, Louis M. Kunkel, A. Reghan Foley, Sandra Donkervoort, Carsten G. Bönnemann, Laura Toledo‐Bravo de Laguna, Andres Nascimento, Daniel Natera‐de Benito, Isabelle Draper, Christine C. Bruels, Christina A. Pacak, Peter B. Kang   +20 more
wiley   +1 more source

A Vanillin‐Derived Inhibitor of Aggregates via Targeting Intrinsically Disordered Regions of Phytoviral Nucleocapsid Protein

Aggregate
Phase separation (PS) plays a fundamental role in organizing aggregates during the viral lifecycle, providing significant opportunities for in viral disease treatment by inhibiting PS. Intrinsically disordered regions (IDRs) have been extensively studied
Yanju Wang, Yuqin Luo, Xin Li, Feifei Chen, Xingjie Zhang, Lu Yu, Runjiang Song, Baoan Song   +7 more
doaj   +1 more source

A metastasis‐associated pannexin‐1 mutant (Panx11‐89) forms a minimalist ATP release channel

The FEBS Journal, EarlyView.
A truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Junjie Wang, Noah J. Levi, Maykelis Diaz‐Solares, Carsten Mim, Gerhard Dahl, Rene Barro‐Soria   +5 more
wiley   +1 more source

The juxtamembrane and carboxy-terminal domains of Arabidopsis PRK2 are critical for ROP-induced growth in pollen tubes. [PDF]

, 2013
Polarized growth of pollen tubes is a critical step for successful reproduction in angiosperms and is controlled by ROP GTPases. Spatiotemporal activation of ROP (Rho GTPases of plants) necessitates a complex and sophisticated regulatory system, in which
Ge, Fu-Rong, Li, Sha, McCormick, Sheila, Wang, Qun, Zhang, Yan, Zhao, Xin-Ying, Zhou, Liang-Zi   +6 more
core   +1 more source

An adamantane‐based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation

The FEBS Journal, EarlyView.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cationic thermosensory channel crucial for cold sensation and menthol response. TRPM8 dysfunction leads to sensory symptoms such as cold allodynia. Targeting TRPM8 is important for treating diseases like peripheral neuropathies and cancer.
Angela Lamberti, Silvio Aprile, David Cabañero, Fabio Travagin, Laura Butron, Gregorio Fernández‐Ballester, Gian Cesare Tron, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel, Ubaldina Galli   +9 more
wiley   +1 more source