Results 51 to 60 of about 388,335 (278)
PLoS Computational Biology, 2021 We propose a stochastic distributed delay model together with a Markov random field prior and a measurement model for bioluminescence-reporting to analyse spatio-temporal gene expression in intact networks of cells.
Måns Unosson +4 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Discrete Dynamics in Nature and Society, 2015 This paper investigates the feedback control for networked discrete-time finite-distributed delays with quantization and packet dropout, and systems induce the H∞ control problem. The compensation scheme occurs in a random way. The quantization of system
Wen-Chiung Hsu +5 more
doaj +1 more source
TUNABLE ULTRA-LONG RANDOM DISTRIBUTED FEEDBACK FIBER LASER [PDF]
Jurnal Teknologi, 2016 A 72 km open-ended symmetrical tunable random distributed feedback fiber laser (RDB-FL) with different pumping schemes is presented in this study. The random distributed feedback was contributed by Rayleigh scattering in the single-mode fiber while distributed gain was provided by the effect of stimulated Raman scattering.
Zainol Abidin, Nadiah Husseini +3 more
openaire +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Stochastic Allocation of Transmit Power for Realistic Wireless Channel Models
The Journal of Engineering Research, 2016 Control of transmitted power is crucial for the successful operation of multi-user wireless channels communications. There are practical situations in which the transmitted power cannot be adjusted by feedback information; hence, only forward transmit ...
N. G. Tarhuni +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
IEEE Photonics Journal, 2017 The properties of light wave propagation with stochastic scattering in a fiber are particularly attractive because of their influence in various applications.
Qiguang Feng, Wei Li, Liyan Huang
doaj +1 more source