Randomised double blind placebo controlled trial of inhaled fluticasone propionate in infants with chronic lung disease [PDF]
, 2002 In a double blind randomised controlled trial, 30 infants with chronic lung disease received fluticasone propionate or placebo for one year. There were no significant differences between treatment groups in the incidence of any day or night time symptoms
Beresford, M.W. +3 more
core +2 more sources
Understanding controlled trials: Randomisation methods in controlled trials
BMJ, 1998 The main purpose of randomisation is to avoid bias by distributing the characteristics of patients that may influence outcome randomly between treatment groups so that any difference in outcome can be explained only by treatment. These characteristics might be demographic ones such age or prognostic factors such as clinical history or disease severity.
Roberts, C., Torgerson, D.
openaire +5 more sources
Randomised controlled trials [PDF]
British Journal of Psychiatry, 2014 A randomised controlled trial (RCT) is an experiment in which the outcomes are compared between participants who have been allocated to comparator treatments or interventions unpredictably and randomly.
openaire +3 more sources
Improving clinical trial interpretation with ACCEPT analyses [PDF]
arXiv, 2022 Effective decision making from randomised controlled clinical trials relies on robust interpretation of the numerical results. However, the language we use to describe clinical trials can cause confusion both in trial design and in comparing results across trials. ACceptability Curve Estimation using Probability Above Threshold (ACCEPT) aids comparison
arxiv
Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: systematic review and meta-regression [PDF]
Multiple Sclerosis Journal, 19(12):1580-1586, 2013, 2013 Background: Recent studies have shown a decrease in annualised relapse rates (ARRs) in placebo groups of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS). Methods: We conducted a systematic literature search of RCTs in RMS.
arxiv +1 more source
The CRASH trial: the first large-scale, randomised, controlled trial in head injury. [PDF]
, 2001 The global epidemic of head injuries is just beginning. Many are caused by road traffic crashes. It is estimated that, by 2020, road traffic crashes will have moved from its present position of ninth to third in the world disease burden ranking, as ...
Roberts, I
core +2 more sources
The Hawthorne Effect: a randomised, controlled trial [PDF]
BMC Medical Research Methodology, 2007 Abstract Background The 'Hawthorne Effect' may be an important factor affecting the generalisability of clinical research to routine practice, but has been little studied. Hawthorne Effects have been reported in previous clinical trials in dementia but to our knowledge, no attempt has been made to quantify them.
McCarney, R +5 more
openaire +5 more sources
Physio4FMD: protocol for a multicentre randomised controlled trial of specialist physiotherapy for functional motor disorder [PDF]
, 2019 Background Patients with functional motor disorder (FMD) experience persistent and disabling neurological symptoms such as weakness, tremor, dystonia and disordered gait.
Buszewicz, M +12 more
core +6 more sources
Optimal Study Designs for Cluster Randomised Trials: An Overview of Methods and Results [PDF]
arXiv, 2023 There are multiple cluster randomised trial designs that vary in when the clusters cross between control and intervention states, when observations are made within clusters, and how many observations are made at that time point. Identifying the most efficient study design is complex though, owing to the correlation between observations within clusters ...
arxiv
Prehospital randomised assessment of a mechanical compression device in cardiac arrest (PaRAMeDIC) trial protocol [PDF]
, 2010 Background Survival after out-of-hospital cardiac arrest is closely linked to the quality of CPR, but in real life, resuscitation during pre-hospital care and ambulance transport is often suboptimal.
Cooke, Matthew +10 more
core +5 more sources