Results 31 to 40 of about 702,734 (359)

A longitudinal assessment of trial protocols approved by research ethics committees: The Adherance to SPIrit REcommendations in the UK (ASPIRE-UK) study

Trials, 2022
Background To assess the quality of reporting of RCT protocols approved by UK research ethics committees before and after the publication of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guideline.
Benjamin Speich, Ayodele Odutayo, Nicholas Peckham, Alexander Ooms, Jamie R. Stokes, Ramon Saccilotto, Dmitry Gryaznov, Belinda von Niederhäusern, Bethan Copsey, Douglas G. Altman, Matthias Briel, Sally Hopewell   +11 more
doaj   +1 more source

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol [PDF]

, 2019
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life.
Allgar, V., Cohen, J. F., Crooks, M. G., Dyson, J., English, A., Hargreaves, I., Hart, S., Hussain, J., Johnson, M., Richardson, G., Swan, F., Twiddy, M., Wright, C.   +12 more
core   +3 more sources

Factors associated with recruitment to randomised controlled trials in general practice: protocol for a systematic review

Trials, 2019
Background Randomised controlled trials (RCTs) are frequently unable to recruit sufficient numbers of participants. This affects the trial’s ability to answer the proposed research question, wastes resources and can be unethical.
Keith R. Moffat, Paul Cannon, Wen Shi, Frank Sullivan   +3 more
doaj   +1 more source

A Randomised Controlled Trial [PDF]

, 2015
Liver surgery is still associated with a high rate of morbidity and mortality. We aimed to compare different haemodynamic treatments in liver surgery. In a prospective, blinded, randomised, controlled pilot trial patients undergoing liver resection were ...
Feldheiser, Aarne, Giebels, Alexander, Hunsicker, Oliver, Koch, Mandy, Pavlova, Velizara, Spies, Claudia D., Stockmann, Martin, Weimann, Karin, Wernecke, Klaus-Dieter   +8 more
core   +1 more source

A pragmatic randomised controlled trial comparing the efficacy of a femoral nerve block and periarticular infiltration for early pain relief following total knee arthroplasty [PDF]

, 2017
Aims The aim of this study was to compare the effectiveness of a femoral nerve block and a periarticular infiltration in the management of early post-operative pain after total knee arthroplasty (TKA).
Achten, Juul, Balasubramanian, S., Costa, Matthew L., Parsons, Helen, Parsons, Nicholas R., Sprowson, A. P., Thompson, P., Wall, Peter D. H.   +7 more
core   +2 more sources

Moxibustion for cephalic version: a feasibility randomised controlled trial

BMC Complementary and Alternative Medicine, 2011
Background Moxibustion (a type of Chinese medicine which involves burning a herb close to the skin) has been used to correct a breech presentation.
Bisits Andrew, Dahlen Hannah, Smith Caroline A, Do Carole K, Schmied Virginia   +4 more
doaj   +1 more source

A randomised controlled trial of cognitive behavioural treatment for obsessive compulsive disorder in children and adolescents [PDF]

, 2009
Cognitive behaviour therapy (CBT) for young people with obsessive compulsive disorder (OCD) has become the treatment of first choice. However, the literature is largely based on studies emphasising exposure and response prevention.
A Mather, C Gallop, D Bolton, D Bolton, DA Geller, DHM Bodden, E Haan De, EB Foa, EB Foa, FR Asbahr, GE Anholt, HB Simpson, Hilary White, HM Douglass, J Derisley, JS Abramowitz, JS March, JS March, JS March, L Matthews, L Scahill, Liz Forrester, M Allsopp, M Kovacs, Mark A. Allsopp, National Collaborating Centre for Mental Health, P Barrett, P Barrett, P Barrett, P Salkovskis, Paul M. Salkovskis, PH Thomsen, PM Salkovskis, PM Salkovskis, S Libby, S Reynolds, Sam Turner, SB Morris, T Williams, Tim I. Williams, WK Silverman   +40 more
core   +4 more sources

Increasing recruitment to randomised trials: a review of randomised controlled trials [PDF]

BMC Medical Research Methodology, 2006
Poor recruitment to randomised controlled trials (RCTs) is a widespread and important problem. With poor recruitment being such an important issue with respect to the conduct of randomised trials, a systematic review of controlled trials on recruitment methods was undertaken in order to identify strategies that are effective.We searched the register of
Judith Watson, David J. Torgerson
openaire   +4 more sources

Randomised controlled trials [PDF]

British Journal of Psychiatry, 2014
A randomised controlled trial (RCT) is an experiment in which the outcomes are compared between participants who have been allocated to comparator treatments or interventions unpredictably and randomly.
openaire   +3 more sources

Does prospective acceptability of an intervention influence refusal to participate in a randomised controlled trial? An interview study

Contemporary Clinical Trials Communications, 2021
Background: The generalizability of findings of Randomised Controlled Trials (RCTs) is undermined by low or biased recruitment. Reasons for participant refusal are infrequently reported in published literature. Aims: To apply the Theoretical Framework of
Mandeep Sekhon, Martin Cartwright, Sadie Lawes-Wickwar, Hayley McBain, Daniel Ezra, Stanton Newman, Jill J Francis   +6 more
doaj