Results 31 to 40 of about 698,130 (312)

Learning from OCTET – exploring the acceptability of clinical trials management methods

Trials, 2018
Background Conducting research can be time consuming, difficult and challenging. Guidance and pragmatic advice focussing on randomised controlled trial conduct are available but do not necessarily constitute comprehensive guidance.
Catherine Arundel, Judith Gellatly
doaj   +1 more source

Manual-assisted cognitive therapy for self-harm in personality disorder and substance misuse: a feasibility trial [PDF]

, 2014
<b>Aims and method</b> To assess the feasibility of conducting a larger, definitive randomised controlled trial of manual-assisted cognitive therapy (MACT), a brief focused therapy to address self-harm and promote engagement in services.
Brown, Tom M., Davidson, Kate M., James, Vairi, Kirk, Jamie, Richardson, Julie   +4 more
core   +1 more source

Factors influencing participation in randomised clinical trials among patients with early Barrett’s neoplasia: a multicentre interview study

BMJ Open, 2023
Objectives Strong recruitment and retention into randomised controlled trials involving invasive therapies is a matter of priority to ensure better achievement of trial aims.
Pradeep Bhandari, Laurence B Lovat, Rehan Haidry, Krish Ragunath, Hugh Barr, Clive Stokes, Mohammad Farhad Peerally, Howard Smart, John De Caestecker, Clare Jackson   +9 more
doaj   +1 more source

A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

Research Integrity and Peer Review, 2019
Background The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the ...
Kaitlyn Hair, Malcolm R. Macleod, Emily S. Sena, on behalf of the IICARus Collaboration   +3 more
doaj   +1 more source

Design considerations for clinical trials in aphasia

Annals of Indian Academy of Neurology, 2020
The use of the randomised controlled trial (RCT) design to evaluate the effectiveness of new interventions in aphasia has increased in recent years in response to calls for high quality evidence of the effectiveness of interventions for this population ...
Rebecca Palmer
doaj   +1 more source

Trial of Acute Femoral Fracture Fixation (TrAFFix): study protocol for a randomised controlled feasibility trial

Trials, 2017
Background Distal femoral fractures are a source of considerable morbidity and best treatment is currently uncertain. The Trial of Acute Femoral Fracture Fixation (TrAFFix) is a randomised, parallel-group feasibility study designed to inform the design ...
Xavier L. Griffin, Matthew L. Costa, Juul Achten, Melina Dritsaki, Janis Baird, Nicholas Parsons   +5 more
doaj   +1 more source

An intervention for people with learning disabilities and epilepsy [PDF]

, 2015
Date of Acceptance: 09/01/2015Epilepsy is relatively common in people with learning disabilities, and can be complex and refractory to treatment, with negative effects on quality of life and service costs.
Durand, Marie-Anne, Gates, Bob, Mengoni, Silvana   +2 more
core   +1 more source

The SMILES trial: an important first step

BMC Medicine, 2018
The SMILES trial was the first intervention study to test dietary improvement as a treatment strategy for depression. Molendijk et al. propose that expectation bias and difficulties with blinding might account for the large effect size.
Felice N. Jacka, Adrienne O’Neil, Catherine Itsiopoulos, Rachelle Opie, Sue Cotton, Mohammadreza Mohebbi, David Castle, Sarah Dash, Cathrine Mihalopoulos, Mary Lou Chatterton, Laima Brazionis, Olivia M. Dean, Allison Hodge, Michael Berk   +13 more
doaj   +1 more source

Randomised controlled trials [PDF]

Postgraduate Medical Journal, 1999
Randomised controlled trials , Alejandro Jadad, pp 128. BMJ Books, 1998. £12.95 (£11.95 to BMA members), paperback. ISBN 0 7279 1208 9. ★★★ The issue of trial design is increasingly recognised as central to the evaluation of the benefit from any healthcare intervention.
openaire   +1 more source

Factors associated with recruitment to randomised controlled trials in general practice: protocol for a systematic review

Trials, 2019
Background Randomised controlled trials (RCTs) are frequently unable to recruit sufficient numbers of participants. This affects the trial’s ability to answer the proposed research question, wastes resources and can be unethical.
Keith R. Moffat, Paul Cannon, Wen Shi, Frank Sullivan   +3 more
doaj   +1 more source