Design considerations for clinical trials in aphasia
Annals of Indian Academy of Neurology, 2020 The use of the randomised controlled trial (RCT) design to evaluate the effectiveness of new interventions in aphasia has increased in recent years in response to calls for high quality evidence of the effectiveness of interventions for this population ...
Rebecca Palmer
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Randomised controlled trials [PDF]
Postgraduate Medical Journal, 1999 Randomised controlled trials , Alejandro Jadad, pp 128. BMJ Books, 1998. £12.95 (£11.95 to BMA members), paperback. ISBN 0 7279 1208 9. ★★★ The issue of trial design is increasingly recognised as central to the evaluation of the benefit from any healthcare intervention.
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Biomarker-guided implementation of the KDIGO guidelines to reduce the occurrence of acute kidney injury in patients after cardiac surgery (PrevAKI-multicentre): protocol for a multicentre, observational study followed by randomised controlled feasibility trial [PDF]
, 2020 Introduction Acute kidney injury (AKI) is a frequent complication after cardiac surgery with adverse short-term and long-term outcomes. Although prevention of AKI (PrevAKI) is strongly recommended, the optimal strategy is uncertain.
Arndt, Christian +29 more
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Clinical trial metadata:Defining and extracting metadata on the design, conduct, results and costs of 125 randomised clinical trials funded by the National Institute for Health Research Health Technology Assessment programme [PDF]
, 2015 Background: By 2011, the Health Technology Assessment (HTA) programme had published the results of over 100 trials with another 220 in progress. The aim of the project was to develop and pilot ‘metadata’ on clinical trials funded by the HTA programme.
Cook, Andrew +6 more
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An intervention for people with learning disabilities and epilepsy [PDF]
, 2015 Date of Acceptance: 09/01/2015Epilepsy is relatively common in people with learning disabilities, and can be complex and refractory to treatment, with negative effects on quality of life and service costs.
Durand, Marie-Anne +2 more
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Contemporary Clinical Trials Communications, 2023 Introduction: Negative symptoms and cognitive impairment are common residual symptoms of schizophrenia that seriously affect the quality of life and social function of patients.
Anbei Lian +7 more
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A single blind, multicenter, randomized controlled trial to evaluate the effectiveness and cost of a novel nutraceutical (LopiGLIK®) lowering cardiovascular disease risk [PDF]
, 2018 Context: Cardiovascular disease (CVD) costs the economy €210 billion per year in Europe. There is an association between low-density lipoprotein cholesterol (LDL-C) and CVD risk.
Izzo, Raffaele +4 more
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Limitations of randomised controlled trials [PDF]
BMJ, 1995 EDITOR,—T C B Dehn has commented on the problems of accruing patients into randomised controlled trials, noting the understandable reluctance of patients to enter some trials (“I want the best treatment, doctor”) in which the patient's outcome (for example, time to death) is the main end point and, consequently, the patient is unable to benefit from ...
L P, Fielding, R, Grace, R, Hittinger
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Indian Journal of Community MedicineBackground: To improve breastfeeding practices, many interventions have been studied at various critical contact points. Our study aimed to improve exclusive breastfeeding by integrating a limited number of counselling sessions with routine immunization ...
Urmimala Maiti +3 more
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Trials, 2022 Background To assess the quality of reporting of RCT protocols approved by UK research ethics committees before and after the publication of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guideline.
Benjamin Speich +11 more
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