Results 11 to 20 of about 8,079,813 (317)

Imbalanced randomization in clinical trials [PDF]

Statistics in Medicine, 2020
Randomization is a common technique used in clinical trials to eliminate potential bias and confounders in a patient population. Equal allocation to treatment groups is the standard due to its optimal efficiency in many cases. However, in certain scenarios, unequal allocation can improve efficiency.
Thevaa Chandereng, Xiaodan Wei, Rick Chappell   +2 more
openaire   +4 more sources

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
O'Kane, Cecilia M., O’Kane, Cecilia M., Laffey, John G, Cross, Mark, John G Laffey, McAuley, Daniel F; id_orcid, McNally, Christine, Michael Stevenson, Perkins, Gavin D., Crealey, Grainne, Laffey, John G., Daniel F McAuley, Murphy, Lynn, HASH(0x55a67ff73468), Stevenson, Michael, Cross, L. J. Mark, Grainne Crealey, Cecilia M O’Kane, McAuley, Daniel F., Mark Cross, null null, Gavin D Perkins, Perkins, Gavin D, Christine McNally, Lynn Murphy, O'Kane, Cecilia M, Cross Mark, Stevenson Michael, Murphy Lynn, McNally Christine, Crealey Grainne, Laffey John G, O’Kane Cecilia M, McAuley Daniel F, Perkins Gavin D, McAuley, Daniel F, and the HARP-2 investigators on behalf of the Irish Critical Care Trials Group, O’Kane, Cecilia M   +37 more
core   +2 more sources

Three controlled trials of interventions to increase recruitment to a randomized controlled trial of mobile phone based smoking cessation support. [PDF]

, 2010
BACKGROUND: Recruitment is a major challenge for trials but there is little evidence regarding interventions to increase trial recruitment. We report three controlled trials of interventions to increase recruitment to the Txt2stop trial.
Free, Caroline, Robertson, Steven, Knight, Rosemary, Hoile, Elizabeth   +3 more
core   +1 more source

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression [PDF]

, 2012
Background: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
Berger Michael, Dittmann, Sandra, Riedel Michael, Sophia, Frangou, Emanuel Severus, Bauer Michael, Severus, Emanuel, Pfennig Andrea, Florian Seemüller, Sophia Frangou, Michael, Bauer, Michael Bauer, Michael Riedel, Berger, Michael, Michael, Obermeier, Andrea, Pfennig, Michael Obermeier, Obermeier Michael, Seemüller Florian, Andrea Pfennig, Michael Berger, Hans-Jürgen, Möller, Dittmann Sandra, Michael, Riedel, Severus Emanuel, Frangou Sophia, Seemüller, Florian, Möller Hans-Jürgen, Sandra Dittmann, Hans-Jürgen Möller   +29 more
core   +2 more sources

Comparison of Pain on Injection of Etomidate versus Etomidate-Lipuro in Patients Undergoing Elective Orthopedic Surgery: A Double-Blind Randomized Clinical Trial

Journal of Orthopedic and Spine Trauma, 2021
Background: Etomidate is an efficient general anesthetic associated with injection pain. Etomidate-Lipuro is its lipid emulsion, suggested to have less adverse effects. We aim to compare the injection pain of etomidate vs.
Alireza Saliminia, Niloofar Esfahanian
doaj   +1 more source

CONSORT for Reporting Randomized Controlled Trials in Journal and Conference Abstracts: Explanation and Elaboration [PDF]

, 2008
BACKGROUND: Clear, transparent, and sufficiently detailed abstracts of conferences and journal articles related to randomized controlled trials (RCTs) are important, because readers often base their assessment of a trial solely on information in the ...
Hopewell, S, Douglas G Altman, Moher, D., Mike Clarke, Schulz, KF, Hopewell, S., Wager, E., Philippa Middleton, The, CG, Sally Hopewell, Schulz, K., Moher, D, Altman, DG, CONSORT Group, Middleton, P, Clarke, M., Hopewel, S, Kenneth F Schulz, Elizabeth Wager, Wager, E, Middleton, P., Hopewell, Sally, David Moher, Altman, D., null null, Clarke, Michael, Haynes, B., Rennie, D., Gebski, V., Goodman, S., Ellenberg, S., Elbourne, D., Schriger, D., Altman, D.G., Grunberg, S., Devereaux, D.J., Montori, V.M., James, A., Pocock, S., Boutron, I., Diderot, D., Dickersin, K., Simera, I.Iveta, Juhn, P., Gøtzsche, P.C., Schulz, K.F., Groves, T., Babour, V., Mulro, C., Minckle, D., Berlin, J.   +50 more
core   +1 more source

A Randomized Trial Comparing Treatments for Varicose Veins [PDF]

, 2014
BACKGROUND: Ultrasound-guided foam sclerotherapy and endovenous laser ablation are widely used alternatives to surgery for the treatment of varicose veins, but their comparative effectiveness and safety remain uncertain. METHODS: In a randomized trial
Ramsay, Craig R, J Scott, Wileman, S., Elders, Andrew, Baker, Sara A., M Gough, G Scotland, Scott, Julian, Scotland, G., Gough, Michael, M K Campbell, E Tassie, J Norrie, S Baker, Burr, Jennifer, Campbell, Marion K, S Wileman, Campbell, Marion K., Burr, J., Bachoo, P., Ramsay, C. R., Lees, T., Baker, S. A., Earnshaw, J., Francis, J., Elders, A., Burr, J. M., Baker, S., S C Cotton, Brittenden, J., Campbell, Marion Kay, Norrie, John, Baker, Sara A, B Campbell, Francis, Jill, J Francis, Tassie, Emma, Scott, J., J M Burr, A Elders, J Earnshaw, Bachoo, Paul, C R Ramsay, Brittenden, Julie, Ramsay, Craig R., Gough, M., Chetter, I., Cotton, S. C., Lees, Tim, Tassie, E., T Lees, Campbell, Bruce, Wileman, Samantha, Campbell, M. K., Chetter, Ian, Campbell, B., Cotton, Seonaidh C, Cotton, Seonaidh C., Neil Stewart, Earnshaw, Jonothan, J Brittenden, Scotland, Graham, Norrie, J., P Bachoo, I Chetter, Burr, Jennifer; id_orcid   +65 more
core   +1 more source

Botulinum Toxin to Improve Lower Blepharoplasty Scar: A Double-Blinded, Randomized, Vehicle-Controlled Clinical Trial

, 2021
BACKGROUND: Lower blepharoplasty is a common cosmetic operation that relies on minimal postoperative scarring, but Asian patients are at higher risk than Caucasians for hypertrophic and/or widened scars. Botulinum toxin type A (BTX) injections are widely
Chen, Zung-Chung, Chang, Frank Chun-Shin, Wallace, Christopher Glenn, Lee, Mei-Ching, Hu, Sindy, Chen, Jyh-Ping, Hsiao, Yen-Chang, Huang, Jung-Ju, Huang, Yau-Li   +8 more
core   +1 more source

DUbbing Language-therapy CINEma-based in Aphasia post-Stroke (DULCINEA): study protocol for a randomized crossover pilot trial

Trials, 2022
Background Communication is one of the most important predictors of social reintegration after stroke. Approximately 15–42% of stroke survivors experience post-stroke aphasia.
Blanca Fuentes, Lydia de la Fuente-Gómez, Cristian Sempere-Iborra, Celia Delgado-Fernández, Aida Tarifa-Rodríguez, María Alonso de Leciñana, Elena de Celis-Ruiz, Raquel Gutiérrez-Zúñiga, José López-Tàppero, Marta Martín Alonso, Sylvia Pastor-Yborra, Ricardo Rigual, Gerardo Ruiz-Ares, Jorge Rodríguez-Pardo, Javier Virués-Ortega, Alberto M. Borobia, Paloma Blanco, Nereida Bueno-Guerra   +17 more
doaj   +1 more source

Development of a New Remote Diagnosis and Treatment Model for Obstructive Sleep Apnea: a Non-inferiority Randomized Controlled Trial Protocol [PDF]

Zhongguo quanke yixue, 2023
Obstructive sleep apnea (OSA) is a high prevalent chronic disease that may lead to many complications, and cause great potential harm to health. Epidemiological studies have showed that OSA is closely related to the development of various cardiovascular ...
YI Huijie, LIAO Xinyi, PI Mengyuan, XU liyue, ZHANG Chi, DONG Xiaosong, HAN Fang
doaj   +1 more source