Results 31 to 40 of about 8,079,813 (317)

Randomized controlled trials in de-implementation research: a systematic scoping review

Implementation Science, 2022
Background Healthcare costs are rising, and a substantial proportion of medical care is of little value. De-implementation of low-value practices is important for improving overall health outcomes and reducing costs.
Aleksi J. Raudasoja, Petra Falkenbach, Robin W. M. Vernooij, Jussi M. J. Mustonen, Arnav Agarwal, Yoshitaka Aoki, Marco H. Blanker, Rufus Cartwright, Herney A. Garcia-Perdomo, Tuomas P. Kilpeläinen, Olli Lainiala, Tiina Lamberg, Olli P. O. Nevalainen, Eero Raittio, Patrick O. Richard, Philippe D. Violette, Jorma Komulainen, Raija Sipilä, Kari A. O. Tikkinen   +18 more
doaj   +1 more source

Ethical and scientific considerations for patient enrollment into concurrent clinical trials. [PDF]

, 2014
Researchers and institutional review boards often consider it inappropriate for patients to be asked to consent to more than one study despite there being no regulatory prohibition on co-enrollment in most countries.
Williamson, Elizabeth, Oakley, Justin, Justin Oakley, Andrew Forbes, Myles, Paul S, Elizabeth Williamson, Forbes, Andrew, Paul S Myles   +7 more
core   +2 more sources

The Standard of Care Definitions on COVID-19 Pharmacological Clinical Trials: A Systematic Review

Frontiers in Pharmacology, 2021
Background: Standard of Care (SoC) has been used with different significance across Randomized Clinical Trials (RCTs) on the treatment of Covid-19. In the context of a living systematic review on pharmacological interventions for COVID-19, we assessed ...
Antonio Addis, Laura Amato, Fabio Cruciani, Rosella Saulle, Franco De Crescenzo, Franco De Crescenzo, Zuzana Mitrova, Simona Vecchi, Francesco Perrone, Marina Davoli   +9 more
doaj   +1 more source

A statistical framework for quantifying clinical equipoise for individual cases during randomized controlled surgical trials [PDF]

, 2011
Background Randomised controlled trials are being increasingly used to evaluate new surgical interventions. There are a number of problematic methodological issues specific to surgical trials, the most important being identifying whether patients are ...
Girling, Alan, Girling Alan, Parsons, Nicholas R., Parsons, NR, Alan Girling, Griffin Damian, Girling, Alan J., Yuri Kulikov, Kulikov Yuri, Damian Griffin, Parsons Nicholas R, Griffin, Damian R., Griffin, D, Kulikov, Y, Kulikov, Yuri, Nicholas R Parsons   +15 more
core   +2 more sources

Randomized clinical trials in Clinical Rehabilitation [PDF]

Clinical Rehabilitation, 2005
A randomized clinical trial (RCT) is currently the strongest method for evaluating interventions in clinical practice. RCTs also provide the politically most powerful form of evidence. However it is not necessarily agreed what constitutes an RCT. This editorial explores what might be included within the rubric of ‘randomized clinical trial' (and ...
openaire   +2 more sources

The Necessity of Randomized Clinical Trials [PDF]

British Journal of Medicine and Medical Research, 2013
Aims: The hierarchy of evidence-based medicine determines the inferential powers of different clinical research designs. We want to address the difficult question if observational evidence under some circumstances can validate intervention effects. Methodology: Assessment of previous argumentation aiming at a clear conclusion for future decision-making.
Christian Jakobsen, Janus, Gluud, Christian   +1 more
openaire   +2 more sources

Reducing the environmental impact of trials: a comparison of the carbon footprint of the CRASH-1 and CRASH-2 clinical trials. [PDF]

, 2011
BACKGROUND: All sectors of the economy, including the health research sector, must reduce their carbon emissions. The UK National Institute for Health Research has recently prepared guidelines on how to minimize the carbon footprint of research.
Subaiya, Saleena, Hogg, Euan, Ian Roberts, Saleena Subaiya, Roberts Ian, Euan Hogg, Hogg Euan, Subaiya Saleena, Roberts, Ian   +8 more
core   +2 more sources

The CHOICE Randomized Clinical Trial

JACC: Cardiovascular Interventions, 2020
We read with interest the paper by Abdel-Wahab et al. ([1][1]) regarding the 5-year outcomes of the CHOICE trial (A Comparison of Transcatheter Heart Valves in High Risk Patients With Severe Aortic Stenosis: The CHOICE Trial).
Bisson, Arnaud, Fauchier, Laurent, Collart, Frederic, Cuisset, Thomas, Deharo, Pierre   +4 more
openaire   +3 more sources

Reach out behavioral intervention for hypertension initiated in the emergency department connecting multiple health systems: study protocol for a randomized control trial

Trials, 2020
Background Hypertension is the most important modifiable risk factor for cardiovascular disease, the leading cause of mortality in the United States.
William J. Meurer, Mackenzie Dinh, Kelley M. Kidwell, Adam Flood, Emily Champoux, Candace Whitfield, Deborah Trimble, Joan Cowdery, Dominic Borgialli, Sacha Montas, Rebecca Cunningham, Lorraine R. Buis, Devin Brown, Lesli Skolarus   +13 more
doaj   +1 more source

ACTIV-6: Operationalizing a decentralized, outpatient randomized platform trial to evaluate efficacy of repurposed medicines for COVID-19

Journal of Clinical and Translational Science, 2023
Despite the availability of vaccinations, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to cause Coronavirus Disease 2019 (COVID-19) infection with a spectrum of disease in the acute setting.
The Accelerating Covid-19 Therapeutic Interventions and Vaccines (ACTIV)-6 Study Group
doaj   +1 more source