Results 21 to 30 of about 8,079,813 (317)

Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial) [PDF]

, 2012
Introduction: Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression. The aim of this study was to determine if the acute administration of atorvastatin reduces sepsis progression in ...
Matthew W Cooke, Patel, Jaimin M, Thickett, David R, David R Thickett, Alan Jones, Anthony H Barnett, Hawkey, P. M., Jaimin M Patel, Catherine Snaith, Perkins, Gavin D., Smith, F. Gao, Jones, Alan, Gao Smith, Fang; id_orcid, Fang Gao, Linhartova, Lucie, Snaith, Catherine, Hong, Tan, Gao, Fang, Tan Hong, Lucie Linhartova, Hawkey, Peter, Peter Hawkey, Cooke, Matthew W, Thickett, David R; id_orcid, Barnett, Anthony H, Cooke, Matthew, Barnett, A. H., Gavin D Perkins, Melody, Teresa, Perkins, Gavin D, Patel, Jaimin M., Thickett, David R., Teresa Melody   +32 more
core   +1 more source

Glossary for randomized clinical trials [PDF]

International Endodontic Journal, 2020
AbstractRandomized clinical trials are positioned at the highest level of primary clinical evidence, as they are designed to be unbiased with a reduced risk of systematic error. The Consolidated Standards of Reporting Trials (CONSORT) statement was first developed in 1996 to improve the reporting quality of randomized clinical trials with updates being
V. Nagendrababu, H. F. Duncan, S. J. Pulikkotil, P. M. H. Dummer   +3 more
openaire   +2 more sources

Introduction of clinical guidelines for the diagnosis and treatment of osteoarthrosis: results of a cluster randomized trial

Научно-практическая ревматология, 2012
Objective: to evaluate the impact of the active introduction of clinical guidelines for the diagnosis and treatment of osteoarthrosis (OA) by primary care physicians on the efficiency of performed therapy and patient adherence to treatment. Methods. This
Dmitri Mikhailovich Maksimov, O M Lesnyak   +1 more
doaj   +1 more source

The effectiveness of alcohol screening and brief intervention in emergency departments: A multicentre pragmatic cluster randomized controlled trial [PDF]

, 2014
Background Alcohol misuse is common in people attending emergency departments (EDs) and there is some evidence of efficacy of alcohol screening and brief interventions (SBI).
Patton, Robert, Dale, V, Eileen Kaner (588847), Deluca Paolo, Drummond, Colin, Gilvarry Eilish, Eilish Gilvarry (588836), Newbury-Birch, Dorothy, Touquet Robin, Judy Myles (588839), Martin Bland (222260), Colin Drummond (339336), Mike Crawford, Cassidy, P, Deluca, Paolo; id_orcid, Patton, R, Bland, Martin, Shepherd Jonathan, Newbury-Birch Dorothy, Eileen Kaner, Adenekan Oyefeso, Myles Judy, Steve Parrott, Heather, Nick, Oyefeso, Adenekan, Parrott, Steve, Colin Drummond, Ruth McGovern, Katherine Perryman, Coulton, S, Patton Robert, Nick Heather (588837), Perryman, K, Paolo Deluca, Steve Parrott (588841), Dorothy Newbury-Birch (588840), Dale, Veronica, Myles, J, Cassidy, Paul, Tom Phillips, Godfrey Christine, Kaner, E, Newbury-Birch, D, Oyefeso, A, Cassidy Paul, Simon Coulton, Robin Touquet (588846), Drummond Colin, Heather Nick, Veronica Dale (588835), Jonathan Shepherd (588845), McGovern Ruth, Oyfeso, Adenekan, Touquet, R, Perryman Katherine, Shepherd, Jonathan, Parrott, S, Phillips, T, Veronica Dale, Paolo Deluca (588833), Christine Godfrey (227956), Paul Cassidy (588834), Ruth McGovern (588838), Adenekan Oyefeso (18454), Godfrey, Christine, Myles, Judy, Jonathan Shepherd, Robin Touquet, Parrott Steve, Christine Godfrey, Perryman, Katherine, Phillips, Tom, Oyefeso Adenekan, Katherine Perryman (588843), Tom Phillips (588844), Judy Myles, Drummond, C, Heather, N, Deluca, Paolo, Coulton, Simon, Coulton Simon, Kaner Eileen, Simon Coulton (167071), Newbury-Birch, Dorothy; id_orcid, Drummond, Colin; id_orcid, Nick Heather, Phillips Tom, Crawford, M, Dorothy Newbury-Birch, Mike Crawford (282626), Bland Martin, Crawford Mike, Dale Veronica, Touquet, Robin, Gilvarry, Eilish, Kaner, Eileen, Robert Patton (588842), McGovern, Ruth, McGovern, R, Patton, Bob, Martin Bland, Crawford, Mike, Torquet, Robin, Robert Patton, Shepherd, J, Philips, Tom, Gilvarry, E, Eilish Gilvarry, Deluca, P, Godfrey, C, Paul Cassidy, Bland, M   +111 more
core   +1 more source

Clinical studies of traditional Japanese herbal medicines (Kampo): Need for evidence by the modern scientific methodology

Integrative Medicine Research, 2021
: Background: Japanese Kampo medicine is a traditional medicine with roots in ancient Chinese medicine. Because traditional physicians had been abolished in Japan, the present mainstream of Kampo treatment is that physicians who learned modern Western ...
Ichiro Arai
doaj   +1 more source

Utility versus futility of facebow in the fabrication of complete dentures: A systematic review

The Journal of Indian Prosthodontic Society, 2020
Aim: The aim of this review was to investigate utility or futility of facebow for fabrication of complete denture prosthesis to maximise clinical efficiency and acceptability of complete dentures.
Poonam Prakash, Kirandeep Singh, Rahul Bahri, S K Bhandari   +3 more
doaj   +1 more source

Statistical analysis plan. Study protocol for a randomized clinical trial to assess 7 versus 14-days of treatment for Pseudomonas aeruginosa bloodstream infections (SHORTEN-2 trial) [PDF]

, 2022
Efficacy and safety of 7 versus 14 days of antibiotic treatment for Pseudomonas aeruginosa bacteraemia: a multicentre, randomized clinical trial (SHORTEN-2) with a DOOR/RADAR analysis.Peer ...
Rosso-Fernández, Clara, Pachón-Ibáñez, M. E., Gimeno, Adelina, Martín-Gutiérrez, Guillermo, Lepe, José A., Cisneros, José Miguel, Guisado-Gil, Ana Belén, Montero-Mateos, Enrique, Álvarez-Marín, Rocío, Molina, José, Paño, José Ramón, Solla, María   +11 more
core   +1 more source

Full-length study protocol (English). Study protocol for a randomized clinical trial to assess 7 versus 14-days of treatment for Pseudomonas aeruginosa bloodstream infections (SHORTEN-2 trial) [PDF]

, 2022
Efficacy and safety of 7 versus 14 days of antibiotic treatment for Pseudomonas aeruginosa bacteraemia: a multicentre, randomized clinical trial (SHORTEN-2) with a DOOR/RADAR analysis.Peer ...
Rosso-Fernández, Clara, Pachón-Ibáñez, M. E., Gimeno, Adelina, Martín-Gutiérrez, Guillermo, Lepe, José A., Cisneros, José Miguel, Guisado-Gil, Ana Belén, Montero-Mateos, Enrique, Álvarez-Marín, Rocío, Molina, José, Paño, José Ramón, Solla, María   +11 more
core   +1 more source

Minimization in randomized clinical trials

Statistics in Medicine, 2023
In randomized trials, comparability of the treatment groups is ensured through allocation of treatments using a mechanism that involves some random element, thus controlling for confounding of the treatment effect. Completely random allocation ensures comparability between the treatment groups for all known and unknown prognostic factors.
Elisabeth Coart, Perrine Bamps, Emmanuel Quinaux, Geneviève Sturbois, Everardo D. Saad, Tomasz Burzykowski, Marc Buyse   +6 more
openaire   +5 more sources

Efficacy and safety of acupuncture for chronic pain caused by gonarthrosis: A study protocol of an ongoing multi-centre randomised controlled clinical trial [ISRCTN27450856]

BMC Complementary and Alternative Medicine, 2004
Background Controlled clinical trials produced contradictory results with respect to a specific analgesic effect of acupuncture. There is a lack of large multi-centre acupuncture trials.
Krämer Jürgen, Knauer Christine, Mansmann Ulrich, Witte Steffen, Streitberger Konrad, Scharf Hanns-Peter, Victor Norbert   +6 more
doaj   +1 more source