Results 141 to 150 of about 2,170,785 (365)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Do inhaled beta-agonists control cough in URIs or acute bronchitis? [PDF]

, 2004
Patients who receive inhaled beta-agonists for cough due to acute upper respiratory infections (URI) are just as likely to report a productive cough at 7 days compared with patients treated with placebo (strength of recommendation [SOR]: A, based on a ...
Nashelsky, Joan, Stephens, Mary Maniscalco   +1 more
core  

A Randomized Controlled Trial [PDF]

Funding Information: This research was financed by national funds through the FCT\u2014Foundation for Science and Technology, I.P., under project 10.54499/UIDB/04585/2020.
Canales, Giancarlo De la Torre, Canhão, Helena, Colaço, Catarina, Manso, Ana Cristina, Mendes, José João, Polido, Mário, Proença, Luís, Santos, Inês Caetano   +7 more
core   +1 more source

Effects of In-Bed Cycle Exercise in Patients With Acute Stroke: A Randomized Controlled Trial

Archives of Rehabilitation Research and Clinical Translation, 2020
Objective: To investigate the effects of in-bed cycle exercise in addition to usual care in patients with acute stroke, National Institutes of Health Stroke Scale (NIHSS) 7-42, regarding walking ability, functional outcomes, and inpatient care days ...
Klas Sandberg, MSc, RPT, Marie Kleist, Bsc, RPT, Magnus Wijkman, MD, PhD, Paul Enthoven, RPT, PhD   +3 more
doaj  

Robust integration of external control data in randomized trials [PDF]

arXiv
One approach for increasing the efficiency of randomized trials is the use of "external controls" -- individuals who received the control treatment studied in the trial during routine practice or in prior experimental studies. Existing external control methods, however, can be biased if the populations underlying the trial and the external control data
arxiv  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

results of a randomized controlled trial [PDF]

, 2016
Bile acids (BAs) are increasingly recognised as metabolic regulators, potentially improving insulin sensitivity following bariatric surgery. However, physiological relevance of such observations remains unknown.
Biemann, Kathleen, Biemann, Ronald, Borucki, Katrin, Goncharenko, Nikolai, Isermann, Berend, Luley, Claus, Lux, Anke, Marschall, Hanns-Ulrich, Penner, Marina, Roenicke, Raik, Schneider, Jochen G., Weikert, Cornelia, Westphal, Sabine   +12 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

A double-masked placebo-controlled trial of azithromycin to prevent child mortality in Burkina Faso, West Africa: Community Health with Azithromycin Trial (CHAT) study protocol. [PDF]

, 2019
BACKGROUND:Biannual, mass azithromycin distribution has previously been shown to reduce all-cause child mortality in sub-Saharan Africa. Subgroup analysis suggested that the strongest effects were in the youngest children, leading to the hypothesis that ...
Bagagnan, Cheik, Boudo, Valentin, Bountogo, Mamadou, Brogdon, Jessica M, Bärnighausen, Till, Coulibaly, Boubacar, Doan, Thuy, Lebas, Elodie, Lietman, Thomas M, Lin, Ying, Oldenburg, Catherine E, Ouattara, Mamadou, Porco, Travis C, Sié, Ali, Étude CHAT Study Group   +14 more
core  

Causal Inference in Randomized Trials with Partial Clustering [PDF]

arXiv
Clustering and dependence are common in trials. For example, in some cluster randomized trials (CRTs), pre-existing clusters are enrolled, randomized, and serve as the basis of intervention delivery. Such CRTs are "fully clustered": participants are dependent within clusters.
arxiv