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Interpreting Randomized Controlled Trials
Cancers, 2023 This article describes rationales and limitations for making inferences based on data from randomized controlled trials (RCTs). We argue that obtaining a representative random sample from a patient population is impossible for a clinical trial because patients are accrued sequentially over time and thus comprise a convenience sample, subject only to ...
Pavlos Msaouel, Juhee Lee, Peter F Thall
openaire +2 more sources
Effect of a Patient-Centered Phone Call by a Clinical Officer at Time of HIV Testing on Linkage to Care in Rural Kenya. [PDF]
, 2018 In a randomized controlled trial, we tested whether a structured, patient-centered phone call from a clinical officer after HIV testing improved linkage to/re-engagement in HIV care. Among 130 HIV-positive persons, those randomized to the phone call were
Ayieko, James +11 more
core +1 more source
Lenalidomide in cancer cachexia: a randomized trial of an anticancer drug applied for anti‐cachexia
JCSM Rapid Communications, 2022 Background Cancer cachexia (CC) impacts quality of life, physical function, anticancer treatment response, and survival. Inflammation is a prominent pathomechanism of CC.
David Blum +6 more
doaj +1 more source
Effectiveness of 4 Pulpotomy Techniques—Randomized Controlled Trial [PDF]
, 2005 Pulpotomy is the accepted therapy for the management of cariously exposed pulps in symptom-free primary molars; however, evidence is lacking about the most appropriate technique.
Crispin, A. +6 more
core +1 more source
BMC Infectious Diseases, 2022 Background Azithromycin is a broad-spectrum antibiotic that has moderate antimalarial activity and has been shown to reduce all-cause mortality when biannually administered to children under five in high mortality settings in sub-Saharan Africa.
Jessica Brogdon +15 more
doaj +1 more source
Optimal allocation strategies in platform trials [PDF]
Statistical Methods in Medical Research, 2024, 2023 Platform trials are randomized clinical trials that allow simultaneous comparison of multiple interventions, usually against a common control. Arms to test experimental interventions may enter and leave the platform over time. This implies that the number of experimental intervention arms in the trial may change over time.
arxiv +1 more source
Randomized Controlled Trials [PDF]
International Journal of Regional Anaesthesia, 2021 A randomized controlled trial (RCT) is a prospective, comparative, quantitative experiment/study that is performed under controlled conditions with random allocation of interventions to comparison groups. Among all the clinical study designs, evidence generated from RCTs is considered to be at top of the evidence pyramid.
Anju Grewal, Nidhi Bhatia
openaire +2 more sources
BMC Musculoskeletal Disorders, 2022 Background Osteoarthritis (OA) is the most common joint disease, and is most frequently seen in the knees. However, there is no effective therapy to relieve the progression of knee OA.
Guangfeng Ruan +16 more
doaj +1 more source
Clinical Research Using Salviae Miltiorrhizae Radix-Pharmacopuncture for Lumbar Herniated Intervertebral Disc: Analysis of Trends [PDF]
Journal of Acupuncture Research, 2021 This review of national and international randomized controlled trials of Salviae miltiorrhizae radix pharmacopuncture for lumbar herniated intervertebral discs was performed to assess its clinical efficacy. There were 5 online databases (PubMed, EMBASE,
Seon Woo Kim +8 more
doaj +1 more source
Combining Real-World and Randomized Control Trial Data Using Data-Adaptive Weighting via the On-Trial Score [PDF]
arXiv, 2021 Clinical trials with a hybrid control arm (a control arm constructed from a combination of randomized patients and real-world data on patients receiving usual care in standard clinical practice) have the potential to decrease the cost of randomized trials while increasing the proportion of trial patients given access to novel therapeutics. However, due
arxiv