Results 101 to 110 of about 3,612,030 (344)

Does furosemide decrease morbidity or mortality for patients with diastolic or systolic dysfunction? [PDF]

, 2005
No large-scale randomized, placebo-controlled trials evaluate furosemide's effect on mortality and long-term morbidity in diastolic or systolic dysfunction.
Blackwell, Jean, Singh, Amrit
core  

Likelihood reweighting methods to reduce potential bias in noninferiority trials which rely on historical data to make inference

, 2013
It is generally believed that bias is minimized in well-controlled randomized clinical trials. However, bias can arise in active controlled noninferiority trials because the inference relies on a previously estimated effect size obtained from a ...
Chu, Jianxiong, Nie, Lei, Rubin, Daniel, Zhang, Zhiwei   +3 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Does physical therapy improve symptoms of fibromyalgia? [PDF]

, 2003
Physical therapy is minimally effective in the treatment of fibromyalgia, with immediate post-treatment improvement in pain and tender points, and both short- and longer-term improved self-efficacy (confidence in performing tasks) (strength of ...
Gokula, Radha Ramana Murthy, Smith, Mindy A., Weismantel, Arlene McFarlin   +2 more
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Impact of the Patient-Clinician Relationship on Medical and Psychological Outcomes: A Meta-Analysis of Randomized Controlled Trials [PDF]

, 2019
The role of the patient-provider relationship in delivery and effectiveness of medical treatments is an emerging research area that should benefit from a review and synthesis of its findings.
Ren-Sun, Joyce
core   +1 more source

Searching a biomedical bibliographic database from the Ukraine: the Panteleimon database [PDF]

, 2005
The Panteleimon database is available via the Internet and is a public access, database, capable of being searched in English, Russian and Ukrainian, covering medical, pharmaceutical, and chemical publications, published in he Ukraine and Russia from ...
Adams, C. E., Kumar, A., Wright, J.
core   +1 more source

Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta‐Analysis of Randomized Controlled Trials

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2016
Background Results from observational and genetic epidemiological studies suggest that lower serum homocysteine levels are associated with lower incidence of cardiovascular disease (CVD).
Yanping Li, Tianyi Huang, Yan Zheng, Tauland Muka, Jenna Troup, F. Hu   +5 more
semanticscholar   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Randomized trials published in some Chinese journals: how many are randomized?

Trials, 2009
Background The approximately 1100 medical journals now active in China are publishing a rapidly increasing number of research reports, including many studies identified by their authors as randomized controlled trials.
Liu Guanjian, Bian Zhaoxiang, Li Youping, Wu Taixiang, Moher David   +4 more
doaj   +1 more source