Results 1 to 10 of about 12,143 (160)

Impact of Regulatory Post-Market Safety Advisories on Prescribing Practices: An Interrupted Time Series Analysis. [PDF]

Clin Pharmacol Ther
Less frequent adverse drug reactions are usually discovered after a drug's release to the market, making effective and timely communication of regulatory post‐market advisories essential for preventing emerging adverse effects. Time series analysis is a key study design for assessing the impact of post‐market safety advisories.
Kim S, Kim S, Kim C, Chang J, Park RW, Kim KW, You SC.   +6 more
europepmc   +2 more sources

Concomitant use of clopidogrel and proton pump inhibitors: A retrospective analysis of prescription behaviour. [PDF]

Br J Clin Pharmacol
Abstract Aims Since omeprazole and esomeprazole reduce the effect of clopidogrel on the inhibition of platelet aggregation, concomitant use of these drugs has been discouraged by the Food and Drug Administration (FDA) and European Medicines Agency (EMA) since 2010.
Wilkes S, van de Wiel K, Mulder K, van Ballegooijen H, Zaal R, van der Kuy H.   +5 more
europepmc   +2 more sources

Clinical characteristics and risk factors for escalation to anaphylaxis from non-severe drug hypersensitivity reaction. [PDF]

Clin Transl Allergy
Abstract Background Drug hypersensitivity reaction (DHR) poses significant challenges in clinical practice, with some patients experiencing more severe reactions upon re‐exposure. Understanding the factors contributing to escalation into more severe reactions is crucial for improving patient safety.
Rhyou HI, Kim SR, Jung JW, Kim SH, Lee JH, Park HJ, Park KH, Park HS, Chung EH, Choi GS, Kim S, Yang MS, Shim JY, Koh YI, Sim DW, Lee JH, Nam YH, Kang HR.   +17 more
europepmc   +2 more sources

Comprehensive Surgical Management of Massive Oesophageal Hiatal Hernia in Squirrel Monkeys (Saimiri sciureus). [PDF]

Vet Med Sci
Radiograph shows displacement of soft tissue from the abdominal region. Abdominal surgery was conducted to reposition the organ, repair the hernia and gastropexy. Case underscores the surgical intervention and the indispensable nature of postoperative care and dietary management in improving the prognosis for animals with hiatal hernias.
Li S, Zhang Z, Kulyar MF, Nawaz S, Li J.
europepmc   +2 more sources

Ranitidine in the newborn. [PDF]

Archives of Disease in Childhood, 1988
An infusion of ranitidine 0.2 mg/kg/hour abruptly halted a life threatening gastrointestinal haemorrhage in an anuric infant of 30 weeks' gestation.
M Rosenthal, P W Miller
openaire   +6 more sources

Oral ranitidine in labour [PDF]

Anaesthesia, 1984
SummaryRanitidine 150 mg orally was given every 6 hours to 909 women in labour, while a control group of 378 women received conventional alkali therapy. No differences in incidences of operative intervention, placental retention or post‐partum haemorrhage were observed between groups.
W. McCAUGHEY, John W. Dundee, D. M. McAULEY, J. Moore   +3 more
openaire   +4 more sources

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Postoperative pain after MiniLap percutaneous versus standard laparoscopic salpingo‐oophorectomy: A propensity‐matched study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The aim of this study was to compare postoperative outcomes in patients undergoing standard laparoscopic salpingo‐oophorectomy versus those using the MiniLap percutaneous surgical system, aiming to demonstrate the non‐inferiority of this ultra‐minimally invasive surgical technique compared to the current gold standard.
Stefano Restaino, Federico Paparcura, Martina Arcieri, Alice Poli, Giulia Pellecchia, Giorgio Bogani, Cristina Taliento, Luigi Della Corte, Federica Perelli, Jvan Casarin, Salvatore Gueli Alletti, Tiziana Bove, Teresa Dogareschi, Lorenza Driul, Francesco Fanfani, Anna Fagotti, Giovanni Scambia, Giuseppe Vizzielli   +17 more
wiley   +1 more source

Relationship of the revised anticholinergic drug scale with cultured cell‐based serum anticholinergic activity and cognitive measures in older adults with mild cognitive impairment or remitted depression

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Objective The Anticholinergic Drug Scale (ADS) is a commonly used measure of anticholinergic exposure. This study describes an expanded and revised version of the ADS (rADS) and its relationship with cultured cell‐based serum anticholinergic activity (cSAA) and cognitive measures.
Ryan M. Carnahan, Susmita Chandramouleeshwaran, Naba Ahsan, Roger Raymond, Jose N. Nobrega, Wei Wang, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, Sanjeev Kumar, Krista L. Lanctôt, Linda Mah, Benoit H. Mulsant, Bruce G. Pollock, Tarek K. Rajji   +14 more
wiley   +1 more source