Results 51 to 60 of about 12,143 (160)
Pediatric Blood &Cancer, Volume 72, Issue 5, May 2025.ABSTRACT Background Asparaginase is a critical component of curative therapy for the treatment of pediatric acute lymphoblastic leukemia (ALL) and acute lymphoblastic lymphoma (LLy). Pegaspargase (PEG) increased the duration of asparagine depletion and lowered the incidence of hypersensitivity reactions (HSRs) compared with native asparaginase.
Kyra McCarty +7 more
wiley +1 more source
Pharmacoepidemiology and Drug Safety, Volume 34, Issue 5, May 2025.ABSTRACT Purpose Tamoxifen is guideline treatment for premenopausal women with estrogen receptor‐positive (ER+) breast cancer. Therapeutic efficacy relies partly on tamoxifen biotransformation by CYP2D6, CYP2C19, and CYP3A4 enzymes. We conducted a cohort study to evaluate whether concomitant prescription of drugs that inhibit these enzymes impacted ...
Kirsten M. Woolpert +11 more
wiley +1 more source
Environmental and Molecular Mutagenesis, Volume 66, Issue 4, Page 210-220, April 2025.ABSTRACT N‐Nitrosamines (NAs) are probable human carcinogens and were detected as impurities in pharmaceuticals, which led to a concern for human health. NAs require metabolic activation before they become mutagenic, and not all NAs are mutagenic since their reactivity is related to their structure.
M. E. Geijer +4 more
wiley +1 more source
Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine
Acta Pharmaceutica, 2015 The present study is aimed at formulation of alginate (ALG) microspheres with ranitidine (RNT) by the spray drying method. Obtained microspheres were characterized for particle size, surface morphology, entrapment efficiency, drug loading, in vitro drug ...
Szekalska Marta +2 more
doaj +1 more source
Exploring Punicalagin Potential Against Cancers: A Comprehensive Review
Food Science &Nutrition, Volume 13, Issue 3, March 2025.This paper focuses on highlighting the therapeutic potential of punicalagin against tumors and cancers. Punicalagin inhibits tumor growth within the body through various cellular pathway interactions. This compound has efficacy in eliminating tumor cells from the liver, stomach, prostate, and lungs.
Muhammad Hammad Ul Hassan +12 more
wiley +1 more source
Synthesis and Dual Histamine H1 and H2 Receptor Antagonist Activity of Cyanoguanidine Derivatives
Molecules, 2013 Premedication with a combination of histamine H1 receptor (H1R) and H2 receptor (H2R) antagonists has been suggested as a prophylactic principle, for instance, in anaesthesia and surgery.
Bassem Sadek +3 more
doaj +1 more source
Canadian Journal of Gastroenterology, 1996 This randomized, single-blind, parallel group study was conducted to compare omeprazole with ranitidine for the treatment of symptoms associated with gastroesophageal reflux disease (GERD), uncomplicated duodenal ulcer (DU) or both.
Andre P Archambault +7 more
doaj +1 more source
Journal of Pharmacy and Bioallied Sciences, 2011 Background: Peptic ulcer is a global health problem of the gastrointestinal tract characterized by mucosal damage secondary to pepsin and gastric acid secretion which occurs due to due to an imbalance between offensive and defensive factors.
Pankaj Kalra +3 more
doaj +1 more source
Journal of Pharmacological Sciences, 2007 Montelukast, a selective reversible cysteinyl leukotriene D4-receptor (LTD4 receptor) antagonist, is used in the treatment of asthma. We have investigated alterations in the glutathione (GSH) and activity levels of antioxidative enzymes [superoxide ...
Gunnur Ozbakis Dengiz +4 more
doaj
Estimates of total costs for treatment of chronic id-iopathic urticaria in adults, depending on the scheme antiallergic therapy [PDF]
Саратовский научно-медицинский журнал, 2010 Objective: Comparative economic evaluation of clinical application of various alternatives to anti-allergic therapy. The total budget for the treatment of severe chronic idiopathic urticaria for the 12 weeks of the study (4 weeks of therapy and 8 weeks ...
Petrov V.I. +3 more
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