Results 231 to 240 of about 1,994,731 (278)

Ligand-specific scoring functions: improved ranking of docking solutions

SAR and QSAR in Environmental Research, 2008
Molecular docking is a powerful computational method that has been widely used in many biomolecular studies to predict geometry of a protein-ligand complex. However, while its conformational search algorithms are usually able to generate correct conformation of a ligand in the binding site, the scoring methods often fail to discriminate it among many ...
T V, Pyrkov, J P, Priestle, E, Jacoby, R G, Efremov   +3 more
openaire   +2 more sources

Quantum probability ranking principle for ligand-based virtual screening

Journal of Computer-Aided Molecular Design, 2017
Chemical libraries contain thousands of compounds that need screening, which increases the need for computational methods that can rank or prioritize compounds. The tools of virtual screening are widely exploited to enhance the cost effectiveness of lead drug discovery programs by ranking chemical compounds databases in decreasing probability of ...
Al-Dabbagh, M. M., Salim, N., Himmat, M., Ahmed, A., Saeed, F.   +4 more
openaire   +3 more sources

Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin

Bone, 2009
Orchiectomized (ORX) rats were used to examine the extent to which their increased bone resorption and decreased bone density might relate to increases in RANKL, an essential cytokine for bone resorption.
Xiaodong, Li, Michael S, Ominsky, Marina, Stolina, Kelly S, Warmington, Zhaopo, Geng, Qing-Tian, Niu, Frank J, Asuncion, Hong-Lin, Tan, Mario, Grisanti, Denise, Dwyer, Steven, Adamu, Hua Zhu, Ke, W Scott, Simonet, Paul J, Kostenuik   +13 more
openaire   +2 more sources

RANK ligand et métastases osseuses

2008
Les cellules tumorales secretent des facteurs osteolytiques dont la plupart agissent via la production par les osteoblastes de RANKL, facteur de la differenciation des osteoclastes.
openaire   +1 more source

Crystal Structure of RANK Ligand Involved in Bone Metabolism

2004
Bone remodeling involves the resorption of bone by osteoclasts and the synthesis of bone matrix by osteoblasts. Recently, an essential cytokine system for osteoclast biology has been identified and extensively characterized. This system consists of a ligand, receptor activator of NF-kappaB ligand (RANKL), a receptor, RANK, and its soluble decoy ...
Shuichiro, Ito, Tadashi, Hata
openaire   +2 more sources

No impact of anti-Rank ligand and PTH analogs on cardiovascular risk in postmenopausal osteoporosis: a systematic literature review and meta-analysis

Archives of Osteoporosis, 2020
L. Ferrières, Y. Degboé, M. Laroche, A. Constantin, A. Ruyssen-Witrand   +4 more
semanticscholar   +1 more source

RANK-Ligand-Hemmung in der Therapie der Osteoporose

2010
Die klinisch relevanten, haufigsten Osteoporoseformen entstehen aufgrund einer exzessiv gesteigerten osteoklastaren Knochenresorption. Hierfur kann es verschiedene Ursachen geben. Mogliche Storungen konnen in der Entstehung (Osteoklastendifferenzierung aus den Vorlauferzellen) und in der Aktivitat (Fusionsstorung, Hemmung der Apoptoseinduktion) der ...
Ulla Stumpf, Walter Josef Fassbender
openaire   +1 more source

Possible mechanisms of the crosstalk between Langerhans cells and regulatory T cells in extramammary Paget disease by receptor activator of nuclear factor kappa B (RANK) ligand/RANK pathways

British Journal of Dermatology, 2017
T. Fujimura, Y. Kambayashi, S. Furudate, Aya Kakizaki, T. Hidaka, S. Aiba   +5 more
semanticscholar   +1 more source

RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers

Nature Medicine, 2016
E. Nolan, F. Vaillant, D. Branstetter, B. Pal, Göknur Giner, L. Whitehead, S. Lok, G. Mann, Kathy Rohrbach, Li-ya Huang, R. Soriano, G. Smyth, W. Dougall, J. Visvader, G. Lindeman   +14 more
semanticscholar   +1 more source

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly