Results 11 to 20 of about 315,545 (404)

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice [PDF]

eLife, 2016
The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy ...
Anderson, Anisimov, Atarashi, Augustine, Bates, Blackwell, Chen, Dai, de Oliveira, Ericsson, Ericsson, Flynn, Goldman, Halloran, Hard, Harrison, Hothorn, Johnson, Johnson, Johnson, Kaeberlein, Lamming, Majumder, Mannick, Mathew, Miller, Miller, Paulson, Prakash, Ramos, Treuting, Wilkinson, Xu, Zhang   +33 more
core   +2 more sources

Rapamycin in the context of Pascal’s Wager: generative pre-trained transformer perspective

Oncoscience, 2022
Large language models utilizing transformer neural networks and other deep learning architectures demonstrated unprecedented results in many tasks previously accessible only to human intelligence. In this article, we collaborate with ChatGPT, an AI model
A. Zhavoronkov
semanticscholar   +1 more source

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Molecular Neurodegeneration, 2021
Novel targets to arrest neurodegeneration in several dementing conditions involving misfolded protein accumulations may be found in the diverse signaling pathways of the Mammalian/mechanistic target of rapamycin (mTOR).
H. Querfurth, Han-Kyu Lee
semanticscholar   +1 more source

Evaluation of off-label rapamycin use to promote healthspan in 333 adults

GeroScience, 2023
Rapamycin (sirolimus) is an FDA-approved drug with immune-modulating and growth-inhibitory properties. Preclinical studies have shown that rapamycin extends lifespan and healthspan metrics in yeast, invertebrates, and rodents.
T. Kaeberlein, A.Stanley Green, G. Haddad, Johnny Hudson, Anar Isman, A. Nyquist, Bradley Rosen, Yousin Suh, Sajad Zalzala, Xingyu Zhang, M. Blagosklonny, Jonathan Y An, M. Kaeberlein   +12 more
semanticscholar   +1 more source

Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy

Nature Aging, 2022
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side effects from continuous dosing. Here we show that geroprotective effects of chronic rapamycin treatment can be obtained with a brief ...
Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F. Drews, J. Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C. Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, L. Partridge   +12 more
semanticscholar   +1 more source

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

Nature Communications, 2022
Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie restriction (CR) potently extends health and lifespan, but is largely unachievable in humans, making “CR mimetics” of great interest.
D. J. Ham, Anastasiya Börsch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtmann, Alexander S. Ham, Marco Thürkauf, Julien Delezie, R. Furrer, Dominik Burri, M. Sinnreich, Christoph Handschin, L. Tintignac, M. Zavolan, Nitish Mittal, M. Rüegg   +15 more
semanticscholar   +1 more source

Combining reverse end-to-side neurorrhaphy with rapamycin treatment on chronically denervated muscle in rats [PDF]

Journal of Integrative Neuroscience, 2021
This preliminary research determines whether a combination of reverse end-to-side neurorrhaphy and rapamycin treatment achieves a better functional outcome than a single application after prolonged peripheral nerve injury.
Yijian Chen, Wanqiong Yuan, Xiaolong Zeng, Yuanchen Ma, Qiujian Zheng, Bofu Lin, Qingtian Li   +6 more
doaj   +1 more source

Effect of rapamycin on aging and age-related diseases—past and future

GeroScience, 2020
In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in life. This observation resulted in a sea-change in how researchers viewed aging.
R. Selvarani, Sabira Mohammed, A. Richardson   +2 more
semanticscholar   +1 more source

Intra‐articular injection of rapamycin microparticles prevent senescence and effectively treat osteoarthritis

Bioengineering & Translational Medicine, 2023
Trauma to the knee joint is associated with significant cartilage degeneration and erosion of subchondral bone, which eventually leads to osteoarthritis (OA), resulting in substantial morbidity and healthcare burden.
Kaamini M. Dhanabalan, Ameya A. Dravid, Smriti Agarwal, Ramanath K. Sharath, Ashok Kumar Padmanabhan, Rachit Agarwal   +5 more
doaj   +1 more source

Rapamycin induces transactivation of the EGFR and increases cell survival. [PDF]

, 2009
The mammalian target of rapamycin (mTOR) signaling network regulates cell growth, proliferation and cell survival. Deregulated activation of this pathway is a common event in diverse human diseases such as cancers, cardiac hypertrophy, vascular ...
Chaturvedi, D, Cohen, MS, Gao, X, Patel, TB, Taunton, J   +4 more
core   +2 more sources