Results 191 to 200 of about 315,545 (404)

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats [PDF]

, 2018
Bové, Calastretti, Carloni, Castedo, Castedo, Chauhan, Chen, Chong, Chong, Donnan, Ferri, Flynn, Fu, Genova, Harada, Hwang, Hwang, Jiang, Kofman, Koh, Li, Li, Lu, Lu, Maiese, Rieker, Sanghera, Santini, Schmued, Shahjouei, Siddiqui, Thyrell, Urbanek, Wang, Wang, Wechsler, Wong, Xie, Xie, Yang, Yin, Zare, Zeng   +42 more
core   +2 more sources

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.

Molecules and Cells, 2006
Dos D. Sarbassov, Siraj M. Ali, Shomit Sengupta, Joon-ho Sheen, Peggy P. Hsu, Alex F Bagley, Andrew L. Markhard, D. Sabatini   +7 more
semanticscholar   +1 more source

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

Involvement of insulin-like growth factor binding proteins (IGFBPs) and activation of insulin/IGF-like signaling (IIS)-target of rapamycin (TOR) signaling cascade in pacific white shrimp, Litopenaeus vannamei exposed to acute low-salinity

, 2023
Huali Feng, Xuan Wang, Huihui Zhou, Kangsen Mai, Gen He, Chengdong Liu   +5 more
openalex   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, EarlyView.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source

Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

Angewandte Chemie, EarlyView.
Macrocycles are effective molecular glues to stabilize the 14‐3‐3/ChREBP interaction. Linker length modulation uncovered an inverse correlation between the macrocycle binding affinity to 14‐3‐3 and its cooperativity in 14‐3‐3/ChREBP stabilization.
Marloes A. M. Pennings, Merel A. W. van den Bosch, Ansgar Oberheide, Carlo J. A. Verhoef, Christian Ottmann, Albert J. Markvoort, Galen P. Miley, Luc Brunsveld   +7 more
wiley   +2 more sources

Image_4_Proteogenic Dipeptides Are Characterized by Diel Fluctuations and Target of Rapamycin Complex-Signaling Dependency in the Model Plant Arabidopsis thaliana.TIF

, 2021
Maria Juliana Calderan-Rodrigues (10631012), Marcin Luzarowski (11865926), Carolina Cassano Monte-Bello (11865929), Romina I. Minen (6369461), Boris M. Zühlke (11865932), Zoran Nikoloski (175457), Aleksandra Skirycz (58031), Camila Caldana (76564)   +7 more
openalex   +2 more sources

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Supplementary Figures 1-4 from Mammalian Target of Rapamycin–Dependent Acinar Cell Neoplasia after Inactivation of <i>Apc</i> and <i>Pten</i> in the Mouse Salivary Gland: Implications for Human Acinic Cell Carcinoma

, 2023
Cassandra R. Diegel, Kathleen R. Cho, Adel K. El‐Naggar, Bart O. Williams, Charlotta Lindvall   +4 more
openalex   +2 more sources