Results 211 to 220 of about 315,545 (404)

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, EarlyView.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source

Gezielte Modulation des spliceosomalen Proteins USP39 durch allosterische Liganden und PROTAC‐induzierte Degradation

Angewandte Chemie, EarlyView.
Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Functionally conserved effects of rapamycin exposure on zebrafish

, 2016
Ceren Sucularlı, Huma Shehwana, Cem Kuscu, Dilay Ciglidag Dungul, Hi̇lal Özdağ, Özlen Konu   +5 more
openalex   +2 more sources

Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin [PDF]

, 2014
Irina G. Popovich, Vladimir N. Anisimov, Mark A. Zabezhinski, Anna V. Semenchenko, Margarita L. Tyndyk, M. N. Yurova, Mikhail V. Blagosklonny   +6 more
openalex   +1 more source

The influence of coronary stenting with rapamycin-eluting stents on the number of circulating CD4+CD25high+regulatory T-cells

Терапевтический архив, 2009
Aim. To investigate the effects of coronary stenting with rapamycin-eluting stents on parameters of cell immunity. Methods. 26 patients (group 1) with stable coronary heart disease and angiographically proved coronary stenosis underwent stenting with ...
Tat'yana Igorevna Aref'eva, Sergey Il'ich Provatorov, Aleksandra Viktorovna Potekhina, Vladimir Olegovich Sokolov, Nadezhda Borisovna Kukhtina, Anatoliy Nikolaevich Samko, Tat'yana Leonidovna Krasnikova, T I Arefieva, S I Provatorov, A V Potekhina, V O Sokolov, N B Kukhtina, A N Samko, T L Krasnikova   +13 more
doaj  

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation

Angewandte Chemie International Edition, EarlyView.
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function [PDF]

, 2008
Lynsey M. Meikle, Kristen Pollizzi, Anna Egnor, Ioannis Kramvis, Heidi A. Lane, Mustafa Şahin, David J. Kwiatkowski   +6 more
openalex   +1 more source

mTOR inhibition: a promise for a young heart.

Frontiers in Physiology, 2012
Stêfany Bruno De Assis Cau, Rita C Tostes   +1 more
doaj   +1 more source

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

Molecules and Cells, 2002
R. Loewith, E. Jacinto, S. Wullschleger, A. Lorberg, J. Crespo, D. Bonenfant, W. Oppliger, P. Jenoe, M. Hall   +8 more
semanticscholar   +1 more source

S6K1 Phosphorylates and Regulates Fragile X Mental Retardation Protein (FMRP) with the Neuronal Protein Synthesis-dependent Mammalian Target of Rapamycin (mTOR) Signaling Cascade

, 2008
Usha Narayanan, Vijayalaxmi Nalavadi, M. Nakamoto, George Thomas, Stephanie Ceman, Gary J. Bassell, Stephen T. Warren   +6 more
openalex   +1 more source