Results 251 to 260 of about 255,378 (313)

Epigallocatechin‐3‐Gallate Suppresses Glioma by Targeting Integrin αvβ3/FAK/ERK Signaling Axis and Matrix Metalloproteinases

Phytotherapy Research, EarlyView.
EGCG suppresses glioma progression by targeting integrin αvβ3/FAK/ERK signaling and inhibiting MMP‐2/MMP‐9‐mediated ECM degradation, thereby blocking proliferation, migration, invasion, and promoting apoptosis. ABSTRACT Epigallocatechin‐3‐gallate (EGCG), the most abundant and biologically active catechin in green tea, has been widely reported to ...
Rui Sun, Yonghan Pan, Ning Yang, Bing Kang, Hong Xiao, Xianglong Tang, Taiping Li, Mengjie Zhao   +7 more
wiley   +1 more source

A Combined Colon Organoid‐Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease

Phytotherapy Research, EarlyView.
Experimental workflow and main findings of the study. ABSTRACT Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity.
Francesco Margiotta, Elena Lucarini, Alessandra Toti, Maria Giovanna Cataldi, Clara Ciampi, Gina Rosalinda De Nicola, Lorenzo Di Cesare Mannelli, Carla Ghelardini   +7 more
wiley   +1 more source

Lysosomal exocytosis by macrophages as a druggable mechanism for anti-inflammatory clearance of dead adipocytes in adipose tissue. [PDF]

Cell Death Dis
Wehr R, Lindhorst A, Arndt L, Krueger M, Raulien N, Gericke M.   +5 more
europepmc   +1 more source

Pathogenesis of Age‐Related Hearing Loss and Therapeutic Strategies

Sensory Neuroscience, EarlyView.
ABSTRACT Age‐related hearing loss (ARHL) is a degenerative disorder of the auditory system, characterized by bilateral symmetrical sensorineural hearing loss that occurs with aging. As a highly prevalent age‐related condition worldwide, ARHL significantly impairs both the quality of life and mental health of the elderly.
Yu Xiao, Jiaxin Liu, Xiaohan Zhang, Miao Chang, Cheng Cheng, Yunhao Wu, Xiaolong Fu   +6 more
wiley   +1 more source

The geroscience hypothesis: Economic paradigms and pharmacological strategies for healthspan extension. [PDF]

J Taibah Univ Med Sci
Alotaibi AF, Aljasser AI, Alkattan AN, Alkhoraisi A, Assiri AM.   +4 more
europepmc   +1 more source

Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk. [PDF]

Front Pharmacol
Tu Y, Liu W, Sang T, Pan L, Wu W, Fang Q, Liu Y, Liu B, Wan Y.   +8 more
europepmc   +1 more source

The mTOR signaling pathway regulates key steps of mammary gland organoid genesis in a temporal manner. [PDF]

Sci Rep
Lacouture A, Sylla MS, Germain L, Fréville L, Lafront C, Weidmann C, Jobin C, Laplante M, Huot MÉ, Lambert JP, Audet-Walsh É.   +10 more
europepmc   +1 more source

Cellular survivorship bias as a mechanistic driver of muscle stem cell aging. [PDF]

Science
Kang J, Benjamin DI, Guo Q, Evangelista C, Kim S, Arjona M, Both P, Chung M, Krishnan AK, Dhaliwal G, Lam R, Rando TA.   +11 more
europepmc   +1 more source

Mechanistic Target of Rapamycin and Megalencephaly: Novel Research Strategies for Therapeutic Discovery. [PDF]

Epilepsy Curr
Pan T, Parker W, Iffland PH, Dang L, Crino PB.   +4 more
europepmc   +1 more source