T-regulatory cells in transplantology: from preparation to clinical applications
Бюллетень сибирской медицины, 2018 The intensive study of the cellular approaches for the correction of different pathologies, including immunopathological processes and oncology, as well as the investigation of the immunosuppressive role of the regulatory T-cells (Tregs) made conditions ...
S. N. Sennikov +2 more
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Cells, 2022 Keratinocyte stem cells play a fundamental role in homeostasis and repair of stratified epithelial tissues. Transplantation of cultured keratinocytes autografts provides a landmark example of successful cellular therapies by restoring durable integrity ...
Giorgia Centonze +3 more
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The Journal of Reproduction and Development, 2022 Any abnormal activation of primordial follicles and subsequent depletion can irreversibly diminish the ovarian reserve, which is one of the major chemotherapy-induced adverse effects in young patients with cancer.
Xiuying CHEN +7 more
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PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells [PDF]
, 2019 Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR).
Althoff, Till F. +14 more
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Prdx5 in the Regulation of Tuberous Sclerosis Complex Mutation-Induced Signaling Mechanisms
Cells, 2023 (1) Background: Tuberous sclerosis complex (TSC) mutations directly affect mTORC activity and, as a result, protein synthesis. In several cancer types, TSC mutation is part of the driver mutation panel.
Judit Bovari-Biri +3 more
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Investigating the effect of target of rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets [PDF]
, 2019 Recuperado de: https://www.biorxiv.org/content/10.1101/310102v1Target of rapamycin (TOR) kinase is a conserved regulator of cell growth whose activity is modulated in response to nutrients, energy and stress.
Couso Liáñez, Inmaculada Concepción +6 more
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Search for Synergistic Drug Combinations to Treat Chronic Lymphocytic Leukemia
Cells, 2022 Finding synergistic drug combinations is an important area of cancer research. Here, we sought to rationally design synergistic drug combinations with an inhibitor of BTK kinase, ibrutinib, which is used for the treatment of several types of leukemia. We
Eleonora Ela Hezkiy +10 more
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mTORC1-Mediated Angiogenesis is Required for the Development of Rosacea
Frontiers in Cell and Developmental Biology, 2021 Although multiple evidences suggest that angiogenesis is associated with the pathophysiology of rosacea, its role is still in debate. Here, we showed that angiogenesis was enhanced in skin lesions of both rosacea patients and LL37-induced rosacea-like ...
Qinqin Peng +33 more
doaj +1 more source
Ornithine Decarboxylase mRNA is Stabilized in an mTORC1-dependent Manner in Ras-transformed Cells [PDF]
, 2012 Upon Ras activation, ODC (ornithine decarboxylase) is markedly induced, and numerous studies suggest that ODC expression is controlled by Ras effector pathways. ODC is therefore a potential target in the treatment and prevention of Ras-driven tumours. In
Albig +51 more
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Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice [PDF]
, 2016 The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy ...
Anderson +33 more
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