Results 21 to 30 of about 315,545 (404)
Combination Kinase Inhibitor Treatment Suppresses Rift Valley Fever Virus Replication
Viruses, 2018 Viruses must parasitize host cell translational machinery in order to make proteins for viral progeny. In this study, we sought to use this signal transduction conduit against them by inhibiting multiple kinases that influence translation.
Todd M. Bell +12 more
doaj +1 more source
Combination Therapy With Rapamycin and Low Dose Imatinib in Pulmonary Hypertension
Frontiers in Pharmacology, 2021 Rationale: Enhanced proliferation and distal migration of human pulmonary arterial smooth muscle cells (hPASMCs) both contribute to the progressive increases in pulmonary vascular remodeling and resistance in pulmonary arterial hypertension (PAH).
Yinan Shi +15 more
doaj +1 more source
A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]
, 2016 mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat +10 more
core +1 more source
Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A
Frontiers in Immunology, 2017 Hemophilia A (coagulation factor VIII deficiency) is a debilitating genetic disorder that is primarily treated with intravenous replacement therapy.
Alexandra Sherman +2 more
doaj +1 more source
T-regulatory cells in transplantology: from preparation to clinical applications
Бюллетень сибирской медицины, 2018 The intensive study of the cellular approaches for the correction of different pathologies, including immunopathological processes and oncology, as well as the investigation of the immunosuppressive role of the regulatory T-cells (Tregs) made conditions ...
S. N. Sennikov +2 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Crohn’s disease (CD)-related fibrotic stricture remains a clinical challenge because of no effective treatments. This study aimed to evaluate the potential efficacy of rapamycin in patients with CD-related strictures in different locations in ...
Min Zhong +12 more
doaj +1 more source
Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin
Neuropsychopharmacology, 2020 Twenty-four hours after administration, ketamine exerts rapid and robust antidepressant effects that are thought to be mediated by activation of the mechanistic target of rapamycin complex 1 (mTORC1).
C. Abdallah +13 more
semanticscholar +1 more source
Journal of the American Society of Nephrology, 2005 Progressive renal disease in the presence of proteinuria is characterized by an infiltration of inflammatory cells into the renal interstitium associated with incremental atrophy of tubular structures and replacement of the tubulointerstitium by fibrous scar.
openaire +4 more sources
Frontiers in Aging Neuroscience, 2021 Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients and has become a major concern for patients and caregivers.
Sunan Gao +8 more
doaj +1 more source
Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]
, 2004 Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry +3 more
core +3 more sources