Results 21 to 30 of about 253,061 (341)

Rapamycin but not FK506 inhibits the proliferation of mononuclear phagocytes induced by colony-stimulating factors [PDF]

, 1994
FK506, CsA, and rapamycin are potent inhibitors of T lymphocyte activation; relatively little is known of their effects on cells of the monocyte/macrophage lineage.
Cooper, MH, Gregory, SH, Starzl, TE, Wing, EJ   +3 more
core   +1 more source

Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

Frontiers in Pharmacology, 2016
The mechanistic target of rapamycin (mTOR), via its two distinct multiprotein complexes, mTORC1 and mTORC2, plays a central role in the regulation of cellular growth, metabolism and migration.
Pei Shi Ong, Louis Z Wang, Xiaoyun Dai, Sheng Hsuan Tseng, Shang Jun Loo, Gautam Sethi   +5 more
doaj   +1 more source

Regulating T Cell Population Alleviates SLE by Inhibiting mTORC1/C2 in MRL/lpr Mice

Frontiers in Pharmacology, 2021
It’s well known that the mammalian target of rapamycin (mTOR) exerts a critical role in the regulator of immune cells and is associated with T cells dysfunction in patients with systemic lupus erythematosus (SLE). Antigen-induced T-cell proliferation via
Dongya Zhang, Meiling Wang, Guoping Shi, Peng Pan, Jianjian Ji, Jianjian Ji, Pengfei Li   +6 more
doaj   +1 more source

Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin. [PDF]

, 2018
While mutations in the fragile X mental retardation-1 (FMR1) gene are associated with varying reproductive outcomes in females, the effects of a complete lack of FMR1 expression are not known.
Ascano, M, Mok-Lin, E, Rosenwaks, Z, Serganov, A, Tuschl, T, Williams, Z   +5 more
core   +2 more sources

Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. [PDF]

, 2000
De novo biosynthesis of amino acids uses intermediates provided by the TCA cycle that must be replenished by anaplerotic reactions to maintain the respiratory competency of the cell. Genome-wide expression analyses in Saccharomyces cerevisiae reveal that
Barbet, Beck, Beck, Brachmann, Cardenas, Chelstowska, Chu, Coffman, Cooper, Courchesne, Cox, Dennis, DeRisi, Di Como, Forsburg, Gangloff, Hardwick, Heitman, Helliwell, Hill, Iiboshi, Iiboshi, Jia, Jiang, Kaffman, Kaffman, Kaffman, Kim, Kitada, Komeili, Koonin, Kos, Lashkari, Liao, Liao, Liu, Longtine, Magasanik, Marzluf, McCammon, McNabb, Menendez, Merrick, Nasmyth, Noda, Ogur, Ogur, Powers, Rosenkrantz, Rothermel, Rothstein, Sekito, Sherman, Sikorski, Small, Spellman, Stryer, Stucka, Sumrada, Thomas, Walker, Zaragoza, Zheng, Zhu   +63 more
core   +3 more sources

Perspectives of targeting mTORC1-S6K1 in cardiovascular aging

Frontiers in Physiology, 2012
The global population aging is accelerating and age-associated diseases including cardiovascular diseases become more challenging. The underlying mechanisms of aging and age-associated cardiovascular dysfunction remain elusive.
Xiu-Fen eMing, Jean-Pierre eMontani, Zhihong eYang   +2 more
doaj   +1 more source

Rapamycin is Effective for Upper but not for Lower Gastrointestinal Crohn’s Disease-Related Stricture: A Pilot Study

Frontiers in Pharmacology, 2021
Crohn’s disease (CD)-related fibrotic stricture remains a clinical challenge because of no effective treatments. This study aimed to evaluate the potential efficacy of rapamycin in patients with CD-related strictures in different locations in ...
Min Zhong, Min Zhong, Bota Cui, Bota Cui, Jie Xiang, Xia Wu, Xia Wu, Quan Wen, Quan Wen, Qianqian Li, Qianqian Li, Faming Zhang, Faming Zhang   +12 more
doaj   +1 more source

Phosphorus Availability Regulates TORC1 Signaling via LST8 in Chlamydomonas [PDF]

, 2020
Target of rapamycin complex 1 (TORC1) is a central regulator of cell growth. It balances anabolic and catabolic processes in response to nutrients, growth factors, and energy availability.
Couso Liáñez, Inmaculada Concepción, Crespo González, José Luis, Ford, Megan M., Hicks, Leslie M., Martínez Force, Enrique, Pérez Pérez, Maria Esther, Umen, James G.   +6 more
core   +1 more source

Normalization of Enzyme Expression and Activity Regulating Vitamin A Metabolism Increases RAR-Beta Expression and Reduces Cellular Migration and Proliferation in Diseases Caused by Tuberous Sclerosis Gene Mutations

Frontiers in Oncology, 2021
BackgroundMutation in a tuberous sclerosis gene (TSC1 or 2) leads to continuous activation of the mammalian target of rapamycin (mTOR). mTOR activation alters cellular including vitamin A metabolism and retinoic acid receptor beta (RARβ) expression.
Elhusseiny Mohamed Mahmoud Abdelwahab, Elhusseiny Mohamed Mahmoud Abdelwahab, Judit Bovari-Biri, Judit Bovari-Biri, Gabor Smuk, Tunde Harko, Janos Fillinger, Janos Fillinger, Judit Moldvay, Judit Moldvay, Vera P. Krymskaya, Judit E. Pongracz, Judit E. Pongracz   +12 more
doaj   +1 more source

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]

, 2016
mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat, Califano, Joseph A, Callejas-Valera, Juan Luis, Cohen, Ezra E, Gutkind, J Silvio, Iglesias-Bartolomé, Ramiro, Lippman, Scott M, Luo, Ji, Molinolo, Alfredo A, Wang, Zhiyong, Yamaguchi, Kosuke   +10 more
core   +1 more source