Results 31 to 40 of about 315,545 (404)

Rapamycin-induced phosphaturia [PDF]

Nephrology Dialysis Transplantation, 2010
The mammalian target of rapamycin (mTOR) is known to stimulate a variety of transport mechanisms including the intestinal phosphate transporter NaPi-IIb. The present study was performed to elucidate whether mTOR similarly regulates the major renal tubular phosphate transporter NaPi-IIa.To this end, NaPi-IIa was expressed in Xenopus oocytes with or ...
Daniela S, Kempe, Miribane, Dërmaku-Sopjani, Henning, Fröhlich, Mentor, Sopjani, Anja, Umbach, Goverdhan, Puchchakayala, Anna, Capasso, Florian, Weiss, Michael, Stübs, Michael, Föller, Florian, Lang   +10 more
openaire   +2 more sources

Rapamycin-Loaded Biomimetic Nanoparticles Reverse Vascular Inflammation

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: Through localized delivery of rapamycin via a biomimetic drug delivery system, it is possible to reduce vascular inflammation and thus the progression of vascular disease.
Christian Boada, Assaf Zinger, Christopher J Tsao, P. Zhao, Jonathan O. Martinez, Kelly A. Hartman, Tomoyuki Naoi, R. Sukhovershin, Manuela Sushnitha, R. Molinaro, B. Trachtenberg, J. Cooke, E. Tasciotti   +12 more
semanticscholar   +1 more source

Normalization of Enzyme Expression and Activity Regulating Vitamin A Metabolism Increases RAR-Beta Expression and Reduces Cellular Migration and Proliferation in Diseases Caused by Tuberous Sclerosis Gene Mutations

Frontiers in Oncology, 2021
BackgroundMutation in a tuberous sclerosis gene (TSC1 or 2) leads to continuous activation of the mammalian target of rapamycin (mTOR). mTOR activation alters cellular including vitamin A metabolism and retinoic acid receptor beta (RARβ) expression.
Elhusseiny Mohamed Mahmoud Abdelwahab, Elhusseiny Mohamed Mahmoud Abdelwahab, Judit Bovari-Biri, Judit Bovari-Biri, Gabor Smuk, Tunde Harko, Janos Fillinger, Janos Fillinger, Judit Moldvay, Judit Moldvay, Vera P. Krymskaya, Judit E. Pongracz, Judit E. Pongracz   +12 more
doaj   +1 more source

Rapamycin but not FK506 inhibits the proliferation of mononuclear phagocytes induced by colony-stimulating factors [PDF]

, 1994
FK506, CsA, and rapamycin are potent inhibitors of T lymphocyte activation; relatively little is known of their effects on cells of the monocyte/macrophage lineage.
Cooper, MH, Gregory, SH, Starzl, TE, Wing, EJ   +3 more
core   +1 more source

mTORC1/ERK1/2 Interplay Regulates Protein Synthesis and Survival in Acute Myeloid Leukemia Cell Lines

Biology, 2023
mTOR is constitutively activated in acute myeloid leukemia (AML) cells, as indicated by the phosphorylation of its substrates, 4EBP1 and P70S6K.
Concetta Anna Germano, Giuseppe Clemente, Antonello Storniolo, Maria Anele Romeo, Elisabetta Ferretti, Mara Cirone, Livia Di Renzo   +6 more
doaj   +1 more source

The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]

, 2007
Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Albert JM, Auernhammer CJ, Boulay A, Boulay A, Bousquet C, Burkhard Göke, Cao C, Christoph J. Auernhammer, Enrico N. De Toni, Faivre S, Gerald Spöttl, Grewe M, Heinrich H.D. Meyer, Hosoi H, Jeng YJ, Jennifer Meinecke, Kathrin Zitzmann, Kawamata S, Kirchner GI, Luo J, O?Reilly KE, Oberg K, Ramage JK, Sawyers CL, Shah T, Shaw RJ, Stephan Brand, Sun SY, Vignot S, von Wichert G, Wang L, Wanner K, Wendel HG, Wullschleger S, Yao JC, Yee KW   +35 more
core   +1 more source

Target of Rapamycin Regulates Genome Methylation Reprogramming to Control Plant Growth in Arabidopsis

Frontiers in Genetics, 2020
DNA methylation is an indispensable epigenetic modification that dynamically regulates gene expression and genome stability during cell growth and development processes.
Tingting Zhu, Tingting Zhu, Linxuan Li, Li Feng, Li Feng, Huijuan Mo, Maozhi Ren, Maozhi Ren   +7 more
doaj   +1 more source

Safety Profile of Rapamycin Perfluorocarbon Nanoparticles for Preventing Cisplatin-Induced Kidney Injury

Nanomaterials, 2022
Cancer treatment-induced toxicities may restrict maximal effective dosing for treatment and cancer survivors’ quality of life. It is critical to develop novel strategies that mitigate treatment-induced toxicity without affecting the efficacy of anti ...
Qingyu Zhou, Justin Doherty, Antonina Akk, Luke E. Springer, Ping Fan, Ivan Spasojevic, Ganesh V. Halade, Huanghe Yang, Christine T. N. Pham, Samuel A. Wickline, Hua Pan   +10 more
doaj   +1 more source

Liuwei Dihuang Pills Inhibit Podocyte Injury and Alleviate IgA Nephropathy by Directly Altering Mesangial Cell-Derived Exosome Function and Secretion

Frontiers in Pharmacology, 2022
Background: Immunoglobulin A nephropathy (IgAN) is the most common glomerular disease worldwide. Its pathological features include IgA immune complex deposition, accompanied by mesangial cell proliferation and mesangial matrix expansion.
Xiaodong Zhu, Xiaodong Zhu, Xiaogang Shen, Bo Lin, Jiaxi Fang, Juan Jin, Qiang He   +6 more
doaj   +1 more source

Investigating the effect of target of rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets [PDF]

, 2019
Recuperado de: https://www.biorxiv.org/content/10.1101/310102v1Target of rapamycin (TOR) kinase is a conserved regulator of cell growth whose activity is modulated in response to nutrients, energy and stress.
Couso Liáñez, Inmaculada Concepción, Crespo González, José Luis, Hicks, Leslie, McConnell, Evan W., Perrine, Zoee, Umen, James G., Werth, Emily G.   +6 more
core   +1 more source