Results 31 to 40 of about 253,061 (341)
, 2021 Inhibition of mTORC1 (mechanistic Target Of Rapamycin Complex 1) signaling promotes health and longevity in diverse model organisms. Over the past decade, excitement has built over the possibility that treatment with the mTORC1 inhibitor rapamycin can be utilized to treat or prevent age-related disease in humans. However, concerns over the side effects
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Frontiers in Aging Neuroscience, 2021 Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients and has become a major concern for patients and caregivers.
Sunan Gao +8 more
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Frontiers in Cell and Developmental Biology, 2022 Rapamycin, also known as sirolimus, an inhibitor of mammalian target of rapamycin (mTOR), is a regulatory kinase responsible for multiple signal transduction pathways.
Minghao Li +11 more
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Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002 [PDF]
, 2016 The phosphatidylinositide 3-kinases (PI3K) and mammalian target of rapamycin-1 (mTOR1) are two key targets for anti-cancer therapy. Predicting the response of the PI3K/AKT/mTOR1 signalling pathway to targeted therapy is made difficult because of network ...
Bown, James L. +4 more
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Animals, 2020 Early weaning stress impairs the development of gastrointestinal barrier function, causing immune system dysfunctions, reduction in feed intake, and growth retardation.
Simeng Liao +11 more
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Combining reverse end-to-side neurorrhaphy with rapamycin treatment on chronically denervated muscle in rats [PDF]
Journal of Integrative Neuroscience, 2021 This preliminary research determines whether a combination of reverse end-to-side neurorrhaphy and rapamycin treatment achieves a better functional outcome than a single application after prolonged peripheral nerve injury.
Yijian Chen +6 more
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Transient Inhibition of mTORC1 Signaling Ameliorates Irradiation-Induced Liver Damage
Frontiers in Physiology, 2019 Recurrent liver cancer after surgery is often treated with radiotherapy, which induces liver damage. It has been documented that activation of the TGF-β and NF-κB signaling pathways plays important roles in irradiation-induced liver pathologies. However,
Wuping Yang +14 more
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Roles of mechanistic target of rapamycin and transforming growth factor-B signaling in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis [PDF]
, 2016 Molting in decapod crustaceans is controlled by molt-inhibiting hormone (MIH), an eyestalk neuropeptide that suppresses production of ecdysteroids by a pair of molting glands (Y-organs or YOs). Eyestalk ablation (ESA) activates the YOs, which hypertrophy
Abuhagr, Ali M. +5 more
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Angewandte Chemie International Edition, 2007 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Maddess, M +7 more
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Rapamycin-induced phosphaturia [PDF]
Nephrology Dialysis Transplantation, 2010 The mammalian target of rapamycin (mTOR) is known to stimulate a variety of transport mechanisms including the intestinal phosphate transporter NaPi-IIb. The present study was performed to elucidate whether mTOR similarly regulates the major renal tubular phosphate transporter NaPi-IIa.To this end, NaPi-IIa was expressed in Xenopus oocytes with or ...
Miribane Dërmaku-Sopjani +10 more
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