Recent advances in rapid antimicrobial susceptibility testing systems
Expert Review of Molecular Diagnostics, 2021Until recently antimicrobial susceptibility testing (AST) methods based on the demonstration of phenotypic susceptibility in 16-24 h remained largely unchanged.Advances in rapid phenotypic and molecular-based AST systems.AST has changed over the past decade, with many rapid phenotypic and molecular methods developed to demonstrate phenotypic or ...
Michael R Jacobs, Daniel D Rhoads
exaly +3 more sources
Blood culture-free ultra-rapid antimicrobial susceptibility testing
Treatment assessment and patient outcome for sepsis depend predominantly on the timely administration of appropriate antibiotics1-3. However, the clinical protocols used to stratify and select patient-specific optimal therapy are extremely slow4. In particular, the major hurdle in performing rapid antimicrobial susceptibility testing (AST) remains in ...
Tae Hyun Kim +19 more
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Development of a new phenotypic technique for rapid antimicrobial susceptibility testing (AST) of methicillin-resistant Staphylococcus aureus is presented. The new technique combines bacterial culturing and specific immunometric detection in a single separation-free process.
Janne O Koskinen +2 more
exaly +3 more sources
Antimicrobial susceptibility testing of Bacteroides fragilis using the MALDI Biotyper antibiotic susceptibility test rapid assay (MBT-ASTRA) [PDF]
This study evaluated the MBT-ASTRA for antimicrobial susceptibility testing of Bacteroides fragilis with different classes of antibiotics. MALDI-TOF MS peak AUCs from suspensions with B.
Ulrik S Justesen +1 more
exaly +4 more sources
Combinatorial screening SlipChip for rapid phenotypic antimicrobial susceptibility testing
Lab on a Chip, 2022A combinatorial-screening SlipChip based on a self-partitioning mechanism performs high-throughput phenotypic AST with a panel of antibiotics and antibiotic combinations in three hours by monitoring the phenotypic profile of bacterial growth.
Xiang Li +8 more
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Rapid Antimicrobial Susceptibility Testing Based on a Bio-Inspired Chemiluminescence Sensor
Analytical Chemistry, 2022Indiscriminate usage of antibiotics has caused accelerating growth and global expansion of antimicrobial resistance. Therefore, rapid antimicrobial susceptibility testing (AST) for guiding antibiotic prescription and preventing the spread of antimicrobial resistance is in urgent need.
Jidong Wang +7 more
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Evaluation of a bioluminescence assay for rapid antimicrobial susceptibility testing of mycobacteria
European Journal of Clinical Microbiology, 1985The antimicrobial susceptibility of Mycobacterium tuberculosis H37Rv and 17 clinical isolates of the same species was determined using a bioluminescence assay to measure adenosine triphosphate (ATP) produced by bacteria in the broth dilution test performed in Dubos-Tween-albumin broth.
B, Beckers +3 more
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An integrated microfluidic chip for rapid and multiple antimicrobial susceptibility testing
The AnalystWe introduce an integrated microfluidic platform, enabling multiple antimicrobial susceptibility testing (AST) and minimum inhibitory concentration (MIC) determination after 2 hours of incubation.
Zirui Pang +3 more
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Rapid susceptibility testing on urine for antimicrobial stewardship in general practice
Journal of Antimicrobial ChemotherapyAbstract Objective Rapid antimicrobial susceptibility testing (AST) can improve antimicrobial management and patient outcome. Urinary tract infection (UTI) is one of the most common reasons for antimicrobial prescription in general practice.
Patrick D J, Sturm, Tanja, Schülin
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A rapid antimicrobial susceptibility test based on single-cell morphological analysis
Science Translational Medicine, 2014An antimicrobial susceptibility test rapidly identifies bacterial response to drugs based on imaged morphology of single cells.
Jungil, Choi +12 more
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