Results 61 to 70 of about 52,598 (267)

Antibiotic Susceptibility Testing with Raman Biosensing

, 2022
Antibiotics guard us against bacterial infections and are among the most commonly used medicines. The immediate consequence of their large-scale production and prescription is the development of antibiotic resistance.
Novikov, Andrei, Kopitsyn, Dmitry, Andrei Novikov, Sayfutdinova, Adeliya, Rawil Fakhrullin, Adeliya Sayfutdinova, Botchkova, Ekaterina, Dmitry Kopitsyn, Fakhrullin, Rawil, Ekaterina Botchkova   +9 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Comparative Assessment of Rapid Identification and Antimicrobial Susceptibility Testing Methods for Bloodstream Infections in a Non-24/7 Clinical Microbiology Laboratory

Microorganisms
Rapid identification and antimicrobial susceptibility testing are essential for timely bloodstream infection (BSI) management. This study aimed to investigate the performance and turnaround time of multiple rapid diagnostic methods in a microbiology ...
Sunggyun Park, Dohoon Kim, Namhee Ryoo
doaj   +1 more source

Rapid Detection of Plasmid AmpC Beta-Lactamases by a Flow Cytometry Assay

Antibiotics, 2022
Plasmidic AmpC (pAmpC) enzymes are responsible for the hydrolysis of extended-spectrum cephalosporins but they are not routinely investigated in many clinical laboratories.
Inês Martins-Oliveira, Blanca Pérez-Viso, Ana Silva-Dias, Rosário Gomes, Luísa Peixe, Ângela Novais, Rafael Cantón, Cidália Pina-Vaz   +7 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Clinical impact of the accelerate PhenoTest® BC system on patients with gram-negative bacteremia and high risk of antimicrobial resistance: a prospective before-after implementation study

Annals of Clinical Microbiology and Antimicrobials, 2023
Background The Accelerate PhenoTest® BC system (AXDX) is a novel assay for rapid bacterial identification and antimicrobial susceptibility (AST). We report an evaluation of its impact on treatment of patients with Gram-negative bacteremia (GNB) with a ...
Tal Brosh-Nissimov, Anka Tzur, Daniel Grupel, Amos Cahan, Nir Ma’aravi, Maya Heled-Akiva, Hasan Jawamis, Hanna Leskes, Erez Barenboim, Nadav Sorek   +9 more
doaj   +1 more source

Rapid assessment of antibiotic susceptibility using a fully 3D-printed impedance-based biosensor

Biosensors and Bioelectronics: X, 2023
The sustained misuse and overuse of antibacterial agents is accelerating the emergence of antimicrobial resistance (AMR), which is becoming one of the major threats to public health.
R. Domingo-Roca, P. Lasserre, L. Riordan, A.R. Macdonald, A. Dobrea, K.R. Duncan, S. Hannah, M. Murphy, P.A. Hoskisson, D.K. Corrigan   +9 more
doaj   +1 more source

Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles

Advanced Materials, EarlyView.
This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen, Xiaoyu Wang, Jilin Fan, Bi Wang, Hanghang Fang, Yurui Wang, Hao Cui, Mohammad Roufarshbaf, Ekaterina Savina, Alexandra Valeske, Quim Peña, Yang Shi, Andreas Herrmann, Twan Lammers, Mathias Hornef, Roman Barmin, Thomas Lisson, Georg Schmitz, Anne Rix, Fabian Kiessling   +19 more
wiley   +1 more source

Growth independent morphometric machine learning workflow for single-cell antimicrobial susceptibility testing of Klebsiella pneumoniae to meropenem

Frontiers in Imaging
IntroductionMultidrug-resistant Enterobacteriaceae are among the most urgent global public health threats associated with various life-threatening infections.
Kristel C. Tjandra, Nikhil Ram-Mohan, Manuel Roshardt, Elizabeth J. Zudock, Zhaonan Qu, Kathleen E. Mach, Okyaz Eminaga, Joseph C. Liao, Joseph C. Liao, Samuel Yang, Pak Kin Wong, Pak Kin Wong   +11 more
doaj   +1 more source

Rapid antibiotic susceptibility testing from blood culture bottles with species agnostic real-time polymerase chain reaction.

PLoS ONE, 2018
Development and implementation of rapid antimicrobial susceptibility testing is critical for guiding patient care and improving clinical outcomes, especially in cases of sepsis.
Tucker Maxson, Candace D Blancett, Amanda S Graham, Christopher P Stefan, Timothy D Minogue   +4 more
doaj   +1 more source