Results 51 to 60 of about 51,266 (243)

An Imaging‐Guided, Patient‐Specific Guiding Aid (RWNGuide) for Safe and Reproducible Inner Ear Drug Delivery

Advanced Materials Technologies, EarlyView.
A patient‐specific, imaging‐guided aid enables precise and reproducible drug delivery to the inner ear. By guiding therapeutic agents directly to the round window niche, this approach reduces variability in drug localization, improves delivery safety, and addresses a critical bottleneck in inner ear therapy, offering a scalable strategy for precision ...
Yanjing Luo, Shanshan Jiang, Yimian Luo, Adele Moatti, Farnaz Matin‐Mann   +4 more
wiley   +1 more source

Clinical impact of the accelerate PhenoTest® BC system on patients with gram-negative bacteremia and high risk of antimicrobial resistance: a prospective before-after implementation study

Annals of Clinical Microbiology and Antimicrobials, 2023
Background The Accelerate PhenoTest® BC system (AXDX) is a novel assay for rapid bacterial identification and antimicrobial susceptibility (AST). We report an evaluation of its impact on treatment of patients with Gram-negative bacteremia (GNB) with a ...
Tal Brosh-Nissimov, Anka Tzur, Daniel Grupel, Amos Cahan, Nir Ma’aravi, Maya Heled-Akiva, Hasan Jawamis, Hanna Leskes, Erez Barenboim, Nadav Sorek   +9 more
doaj   +1 more source

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le, Anh Tuan Trong Tran, Ammara Waheed, Tran Thanh Tung, Dusan Losic   +4 more
wiley   +1 more source

A Cell Phone–Based Microphotometric System for Rapid Antimicrobial Susceptibility Testing [PDF]

SLAS Technology, 2014
This study demonstrates a low-cost, portable diagnostic system for rapid antimicrobial susceptibility testing in resource-limited settings. To determine the antimicrobial resistance phenotypically, the growth of pathogens in microwell arrays is detected under different antibiotic conditions.
Meichei Wang, Kadlec, David, You, Joseph C, Liao, Pak Kin, Wong   +3 more
openaire   +2 more sources

Multifunctional Adhesive Hydrogel for Rapid Cardiac Hemostasis and Antibacterial Protection

Advanced Materials Technologies, EarlyView.
A multifunctional polyacrylamide/gelatin/tannic acid hydrogel (PGT) is presented for rapid cardiac hemostasis under wet, dynamic conditions. Surface tannic acid coating enables instantaneous wet adhesion, accelerates coagulation, and confers antibacterial activity within a single platform.
Seoha Kim, Kaeun Chae, Inseon Kim, Kye Il Joo, Chang Sup Kim, Seunghun S. Lee   +5 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Clinical Impact of Rapid Antimicrobial Susceptibility Testing of Blood Culture Isolates [PDF]

Antimicrobial Agents and Chemotherapy, 1982
The results of a rapid, direct blood culture disk susceptibility test indicated that antimicrobial chemotherapy should be changed in 48 of 173 patients with bacteremia. In 32 patients (66.6%), the indicated change was made approximately 24 h sooner than if conventional, nonrapid susceptibility tests had been used to guide therapy.
G V, Doern, D R, Scott, A L, Rashad
openaire   +2 more sources

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Practice of standardization of CLSI M45 A3 antimicrobial susceptibility testing of Infrequently Isolated or Fastidious Bacteria strains isolated from blood specimens in Guangdong Province 2017–2021

Frontiers in Microbiology
The concentration of antimicrobial agents in environments like water and food has increased rapidly, which led to a rapid increase in antimicrobial resistance levels in the environment.
Nanhao He, Xu Yang, Anwarul Haque, Jiakang Chen, Yingyi Guo, Jiahui Li, Likang Yao, Chuyue Zhuo, Jiong Wang, Yijing Wang, Mingxin Li, Yexin Lin, Shunian Xiao, Chao Zhuo   +13 more
doaj   +1 more source

Advances in Rapid Detection and Antimicrobial Susceptibility Tests: A Review

Defence Life Science Journal, 2018
The rise of antibiotic resistance is an emerging problem of the millennium. Clinical microbiology plays an important role in combating the problem by facilitating diagnostics and therapeutics thus managing infection in patients. Diagnostic failures are a major limiting factor during bacterial infection that causes inappropriate use of antibiotics ...
Shashi Bala Singh, Bhuvnesh Kumar, Lilly Ganju, Divya Singh, Kamla Prasad Mishra, Priyanka Mishra   +5 more
openaire   +2 more sources