Results 151 to 160 of about 5,593,091 (310)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Rapid method for detection and characterization of steroids [PDF]
Analytical Chemistry, 1972 Steel, Gordon, Henderson, William.
openaire +3 more sources
A Colorimetric Aptasensor for Rapid Detection of Sulfadimethoxine in Aquaculture. [PDF]
Biosensors (Basel)Liang H, Tan J, Wang T, Wang Y, Zhang C.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Dump Trucks at Pactola Dam Construction Site, Silver City, Pennington County
, 1956 4 x 5 photograph, various trucks and vehicles at an open areaMiscellaneous Subject File Black Hills Accommodations, Caves, Harney Peak, Lakes P77 Tab Lakes Black Hills Poster board Pactola Dam P77 [stamp] Property of South Dakota State Historical ...
Rapid City Journal
core
A rapid detection of Nipah virus nucleocapsid antigen in inactivated viral cultures. [PDF]
Emerg Microbes InfectChoi G +17 more
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Development and clinical validation of a colorimetric isothermal assay for rapid detection of monkeypox virus. [PDF]
New Microbes New InfectNandi SS +7 more
europepmc +1 more source