Results 61 to 70 of about 465,551 (267)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Clinical diagnostic accuracy of the HIV rapid test ACCU-TELL anti-HIV 1 + 2 in sub-Saharan African region

BMC Infectious Diseases
Human Immunodeficiency Virus (HIV) is still a major health challenge. Around 1.5 million people are newly infected with HIV in the world every year. Screening and identification of HIV infected individuals is a major health challenge in the management of
Veronique M´pirah, Steeve Mbomo, Armel Mintsa, Amel Alame Emane, Ngondziga Ongala Djeff Chirack, Ndong Mebaley Telstar Ghestin, Quenard Edwina Lorine, Saidou Mahmoudou, Joel Fleury Djoba Siawaya, Paulin N. Essone   +9 more
doaj   +1 more source

Rapid Diagnostic Tests in Childhood Infections

Indian Pediatrics, 2018
Presumptive treatment of infections often results in irrational antimicrobial use resulting in detrimental spread of drug resistance and untoward side effects. A rapid diagnostic test (RDT) is a test that delivers a result earlier than conventional testing methods employed in the past to identify the offending microorganism.
openaire   +2 more sources

Malaria rapid diagnostic tests: challenges and prospects

Journal of Medical Microbiology, 2013
In the last decade, there has been an upsurge of interest in developing malaria rapid diagnostic test (RDT) kits for the detection ofPlasmodiumspecies. Three antigens –Plasmodiumfalciparumhistidine-rich protein 2 (PfHRP2), plasmodial aldolase and plasmodial lactate dehydrogenase (pLDH) – are currently used for RDTs.
Joel C, Mouatcho, J P Dean, Goldring
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Evaluation of standard diagnostic rapid test kits for malaria diagnosis among HIV patients in Kano, Nigeria

African Journal of Laboratory Medicine, 2018
Background: Malaria diagnosis among HIV-positive patients is uncommon in Nigeria despite the high burden of both diseases. Objectives: We evaluated the performance of a malaria rapid diagnostic test (MRDT) against blood smear microscopy (BSM) among HIV ...
Henry A. Mbah, Feyisayo E. Jegede, Surajudeen A. Abdulrahman, Tinuade I. Oyeyi   +3 more
doaj   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Utility of rapid diagnostic tests and microscopy to detect malaria in health facilities across the Solomon Islands

Malaria Journal
Background Accurate and efficient malaria diagnosis is critical for effective malaria control and elimination. Rapid diagnostic tests (RDTs) have been deployed over the last decade, particularly in rural and low-and-middle-income countries, as an ...
Genevieve Kerr, Lyndes Wini, John Leaburi, Joanne Macdonald, Tanya L. Russell   +4 more
doaj   +1 more source