Results 61 to 70 of about 1,840,121 (280)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Modelling of the binary alloy solidification process [PDF]

, 1992
Bibliography: leaves 129-132.A thermodynamically consistent model capable of modelling a binary alloy undergoing solidification or melting is developed. The theory is continuum based, and the solid-liquid phase change system is described macroscopically ...
McAdie, R L
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A lattice Boltzmann model with sharp interface tracking for the motion and growth of dendrites in non-equilibrium solidification of alloys

Materials & Design
A lattice Boltzmann model (LBM) with sharp interface tracking is developed to simulate the motion and growth of dendrites in non-equilibrium solidification of alloys. The model is validated through comparative analysis with the drafting-kissing-tumbling (
Shilin Mao, Mengdan Hu, Wei Chen, Dongke Sun   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Research progress in metallic materials solidification based on synchrotron radiation imaging technology

Cailiao gongcheng
Solidification is crucial in the preparation of metal materials. The solidification process directly determines the microstructure and macroscopic properties of metal materials.
JIANG Jiale, KANG Yongwang, LUO Jun, WANG Zhimao, LI Gang, LIU Changkui, LI Nan   +6 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Enhanced corrosion resistance of AZ91D magnesium alloy through refined and homogeneous microstructure by rapid solidification and hot extrusion technique

Materials & Design
Achieving both high corrosion resistance and strength simultaneously has always been a long-standing goal for lightweight structural materials. In this study, we prepared an AZ91D magnesium alloy with a refined and homogeneous microstructure by rapid ...
Jianwei Li, Jiarun Kou, Chao Yang, Hangmai Qi, Wenfeng Gao, Shijia Mu, Yungui Chen   +6 more
doaj   +1 more source

Microstructure and mechanical properties of Mg-2.5Si-xCe in-situ particle reinforced composites prepared by rapid solidification process

Results in Physics, 2019
In this study, Mg-2.5Si-xCe alloys with different Ce contents were fabricated by a rapid solidification process. Two different in-situ phases, namely coarse primary Mg2Si with a size of ∼10 μm and tiny CeMg2Si2 with a size
Wenduo Han, Ke Li, Fei Hu, Yaohui Li, Binbing Tang   +4 more
doaj   +1 more source