Results 201 to 210 of about 394,130 (296)

KRAS Mutations Predict Inferior Post‐Remission Outcomes in Newly Diagnosed Acute Myeloid Leukemia With MAPK Pathway Mutations

European Journal of Haematology, EarlyView.
ABSTRACT Somatic mutations in the MAPK signaling pathway are frequently identified at AML diagnosis; however, their impact on treatment resistance and long‐term survival remains unclear. We conducted a retrospective study of patients with newly diagnosed MAPK‐mutated AML seen at the University of Iowa Health Care.
Kensuke Takaoka, Sarah Mott, Ratdanai Yodsuwan, Sakditad Saowapa, Manasawee Tanariyakul, Chalothorn Wannaphut, Kittika Poonsombudlert   +6 more
wiley   +1 more source

Crhr1 and epinephrine utilize the central Ras-MAPK pathway in mediating the acute stress-related locomotor activity in zebrafish larvae. [PDF]

Front Endocrinol (Lausanne)
Khalid E, Vijayan MM.
europepmc   +1 more source

Autism spectrum disorder and other neurobehavioural comorbidities in rare disorders of the Ras/MAPK pathway

Developmental Medicine & Child Neurology, 2017
S. Garg, A. Brooks, A. Burns, E. Burkitt‐Wright, B. Kerr, S. Huson, R. Emsley, J. Green   +7 more
semanticscholar   +1 more source

Exercise‐related microRNAs in Caenorhabditis elegans regulate calcium homeostasis and mitochondrial dynamics: Conserved pathways, divergent microRNAs

The FEBS Journal, EarlyView.
Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia, Jiwang Tang, José C. Casas‐Martinez, Penglin Li, Maria Borja‐Gonzalez, Leo R Quinlan, Katarzyna Goljanek‐Whysall, Brian McDonagh   +7 more
wiley   +1 more source

GRB2 promotes brain metastasis in HER2-positive breast cancer by regulating the Ras/MAPK pathway. [PDF]

Sci Rep
Li H, Zhang Y, Han X, Li B, Liu D, Sun G.   +5 more
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Evaluation of information flows in the RAS-MAPK system using transfer entropy measurements. [PDF]

Elife
Umeki N, Kabashima Y, Sako Y.
europepmc   +1 more source

Distinct hyperactive RAS/MAPK alleles converge on common GABAergic interneuron core programs.

Development, 2023
Knowles SJ, Stafford AM, Zaman T, Angara K, Williams MR, Newbern JM, Vogt D.   +6 more
europepmc   +1 more source

Traditional serrated adenoma of the colorectum: Evolving concepts in histological classification and terminology

Histopathology, EarlyView.
The definition of the colorectal traditional serrated adenoma (TSA) has evolved to recognize a broader morphological spectrum, including classical, flat and mixed lesions reflecting early development and neoplastic progression. Updated WHO classification highlights the need for consistent terminology to improve recognition and to distinguish TSA from ...
Christophe Rosty, Maurice B. Loughrey, Taiki Hashimoto, Markus Mäkinen, Rish K. Pai, Shigeki Sekine, Rhonda K. Yantiss, Iris D. Nagtegaal   +7 more
wiley   +1 more source

Ellipticine targets FGFR3 to mediate the RAS/MAPK-P38 signalling pathway to induce apoptosis in hepatocellular carcinoma cells. [PDF]

3 Biotech
Ling D, Xiang C, Guolin H, Huisheng S, Xiaohua N.   +4 more
europepmc   +1 more source