Results 81 to 90 of about 394,130 (296)
Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review
Advanced Materials, EarlyView.Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase +6 more
wiley +1 more source
Partners in crime: the TGFβ and MAPK pathways in cancer progression
Cell & Bioscience, 2011 The TGFβ and Ras-MAPK pathways play critical roles in cell development and cell cycle regulation, as well as in tumor formation and metastasis. In the absence of cellular transformation, these pathways operate in opposition to one another, where TGFβ ...
Chapnick Douglas A +4 more
doaj +1 more source
Multiple sources of signal amplification within the B-cell Ras/MAPK pathway
bioRxiv, 2018 The Ras-Map kinase (MAPK) cascade underlies functional decisions in a wide range of cell types and organisms. In B cells, positive feedback-driven Ras activation is the proposed source of the digital (all-or-none) MAPK responses following antigen ...
J. Mclaurin, O. Weiner
semanticscholar +1 more source
Advanced Science, EarlyView.This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li +14 more
wiley +1 more source
Human Molecular Genetics, 2018 Noonan syndrome (NS), the most common RASopathy, is caused by mutations affecting signaling through RAS and the MAPK cascade. Recently, genome scanning has discovered novel genes implicated in NS, whose function in RAS-MAPK signaling remains obscure ...
M. Motta +10 more
semanticscholar +1 more source
Ras Mapk Growth Effectors in Drosophila [PDF]
, 2019 The evolutionary conserved Erk Mapk (mitogen activated protein kinase) pathway coordinates essential cellular functions including cell survival, division, growth, motility and differentiation [9,61]. To execute such intricate functions, Erk regulates transcription factors impinging on gene expression, and a vast assortment of cytosolic and nuclear ...
openaire +1 more source
Advanced Science, EarlyView.A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley +1 more source
Journal of Investigative Dermatology, 2019 Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naive tumors responsiveness to Smoothened inhibitors (Smoi), resistance in advanced tumors remains ...
F. Kuonen +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li +15 more
wiley +1 more source
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
Nature Genetics, 2015 The majority of patients with neuroblastoma have tumors that initially respond to chemotherapy, but a large proportion will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown.
T. F. Eleveld +45 more
semanticscholar +1 more source