Results 91 to 100 of about 370,587 (208)

Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. [PDF]

Cancer Discov, 2022
Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, Durham BH, Pavletich TS, Fiala E, Walsh MF, Inoue D, Monette S, Taylor J, Rosen N, McCormick F, Lindsley RC, Castel P, Abdel-Wahab O.   +26 more
europepmc   +1 more source

Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors. [PDF]

Proc Natl Acad Sci U S A, 2022
Lai LP, Fer N, Burgan W, Wall VE, Xu B, Soppet D, Esposito D, Nissley DV, McCormick F.   +8 more
europepmc   +1 more source

Binding of Vav to Grb2 through dimerization of Src homology 3 domains [PDF]

, 1994
The protooncogenic protein Vav has the structure of an intracellular signal transducer. It is exclusively expressed in cells of hematopoietic lineage and plays a crucial role in hematopoietic cell differentiation.
Baltimore, David, Ye, Zheng-Sheng
core  

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.

PLoS ONE, 2009
BackgroundRegulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Galpha-mediated GTP hydrolysis ("GTPase-accelerating proteins" or GAPs).
Francis S Willard, Melinda D Willard, Adam J Kimple, Meera Soundararajan, Emily A Oestreich, Xiaoyan Li, Nathaniel A Sowa, Randall J Kimple, Declan A Doyle, Channing J Der, Mark J Zylka, William D Snider, David P Siderovski   +12 more
doaj   +1 more source

Absolute Quantification of Endogenous Ras Isoform Abundance.

PLoS ONE, 2015
Ras proteins are important signalling hubs situated near the top of networks controlling cell proliferation, differentiation and survival. Three almost identical isoforms, HRAS, KRAS and NRAS, are ubiquitously expressed yet have differing biological and ...
Craig J Mageean, John R Griffiths, Duncan L Smith, Michael J Clague, Ian A Prior   +4 more
doaj   +1 more source

The Role of R-Ras Proteins in Normal and Pathologic Migration and Morphologic Change. [PDF]

Am J Pathol, 2021
Weber SM, Carroll SL.
europepmc   +1 more source

Kinetic and Structural Analysis of the Mg2+ -binding Site of the Guanine Nucleotide-binding Protein p21 H-ras. [PDF]

, 1993
The coordination and binding of the Mg2+ ion in the nucleotide−binding site of p21 have been investigated using site−directed mutagenesis, kinetic methods, and phosphorous NMR.
Borasio, Gian Domenico, Goody, R. S., John, J., Rensland, H., Schlichting, I., Vetter, I., Wittinghofer, A.   +6 more
core  

IQ Motif Containing GTPase Activating Proteins (IQGAPs), A-Kinase Anchoring Proteins (AKAPs) and Kinase Suppressor of Ras Proteins (KSRs) in Scaffolding Oncogenic Pathways and Their Therapeutic Potential. [PDF]

ACS Omega, 2022
Mohapatra T, Dixit M.
europepmc   +1 more source

NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane. [PDF]

Life Sci Alliance, 2021
Ahearn IM, Court HR, Siddiqui F, Abankwa D, Philips MR.   +4 more
europepmc   +1 more source

Sequence-Selective Covalent CaaX-Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling. [PDF]

ChemMedChem, 2021
Franz M, Mörchen B, Degenhart C, Gülden D, Shkura O, Wolters D, Koch U, Klebl B, Stoll R, Helfrich I, Scherkenbeck J.   +10 more
europepmc   +1 more source