Results 191 to 200 of about 380,814 (333)

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

RESEARCH CHALLENGES IN STAGE III AND IV RAS-ASSOCIATED CANCERS: A Narrative Review of the Complexities and Functions of the Family of <i>RAS</i> Genes and Ras Proteins in Housekeeping and Tumorigenesis. [PDF]

Biology (Basel)
McDonald RA, Varela-Ramirez A, Ashley AK.   +2 more
europepmc   +1 more source

Inhibitors of G12C Mutant Ras Proteins for the Treatment of Cancers. [PDF]

ACS Med Chem Lett, 2019
Kargbo RB.
europepmc   +1 more source

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins

, 1992
John F. Hancock, K. Cadwaller, Hugh Paterson, Chris Marshall   +3 more
openalex   +2 more sources

Promoted Skin Wound Healing by Tail-AmputatedEisenia foetidaProteins via the Ras/Raf/MEK/ERK Signaling Pathway

, 2023
Tianyi Li, Yujie Sun, Jiaqi Wang, Chenning Zhang, Yikun Sun, Yikun Sun, Yikun Sun   +6 more
openalex   +1 more source

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Active R-RAS2/TC21 prevents cell cycle arrest and morphological alterations in mouse embryonic fibroblasts lacking RAS proteins. [PDF]

Oncogene
Fernández-Pisonero I, Lorenzo-Martín LF, Drosten M, Santos E, Barbacid M, Alarcón B, Bustelo XR.   +6 more
europepmc   +1 more source

The protonation states of GTP and GppNHp in Ras proteins. [PDF]

J Biol Chem, 2018
Mann D, Güldenhaupt J, Schartner J, Gerwert K, Kötting C.   +4 more
europepmc   +1 more source

Adenosine A2A Receptor mRNA Regulation by Nerve Growth Factor Is TrkA-, Src-, and Ras-dependent via Extracellular Regulated Kinase and Stress-activated Protein Kinase/c-Jun NH2-terminal Kinase [PDF]

, 1999
Renae L. Malek, Zhongzhen Nie, Vickram Ramkumar, Norman H. Lee   +3 more
openalex   +1 more source

Data from A Conserved RAS/Mitogen-Activated Protein Kinase Pathway Regulates DNA Damage–Induced Cell Death Postirradiation in Radelegans

, 2023
Joanne B. Weidhaas, David M. Eisenmann, Justin M. Holub, Sunitha Nallur   +3 more
openalex   +1 more source