Results 61 to 70 of about 380,814 (333)

Pharmacological modulation of oncogenic Ras by natural products and their derivatives: renewed hope in the discovery of novel anti-Ras drugs [PDF]

, 2016
Oncogenic rat sarcoma (Ras) is linked to the most fatal cancers such as those of the pancreas, colon, and lung. Decades of research to discover an efficacious drug that can block oncogenic Ras signaling have yielded disappointing results; thus, Ras was ...
Quah, Shun Ying, Stanslas, Johnson, Tan, Michelle Siying, Teh, Yuan Han   +3 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by ras^V12 mutated protein and the E1A oncogene

Molecular Cancer, 2003
Background Ras is an area of intensive biochemical and genetic studies and characterizing downstream components that relay ras-induced signals is clearly important.
Berthezene Patrice, Labrie Claude, Calvo Ezequiel L, Malicet Cédric, Vasseur Sophie, Dagorn Jean, Iovanna Juan   +6 more
doaj   +1 more source

Gi- and Gs-coupled GPCRs show different modes of G-protein binding. [PDF]

, 2018
More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered.
Altenbach, Christian, Caro, Lydia N, Dror, Ron O, Ernst, Oliver P, Hollingsworth, Scott A, Hubbell, Wayne L, Latorraca, Naomi R, Van Eps, Ned   +7 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification

Frontiers in Molecular Biosciences, 2021
RAS is a founding member of the RAS superfamily of GTPases. These small 21 kDa proteins function as molecular switches to initialize signaling cascades involved in various cellular processes, including gene expression, cell growth, and differentiation ...
Natsuki Osaka, Yoshihisa Hirota, Yoshihisa Hirota, Doshun Ito, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Yuki Fujii, Venkat R. Chirasani, Sharon L. Campbell, Koh Takeuchi, Toshiya Senda, Toshiya Senda, Toshiya Senda, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki   +18 more
doaj   +1 more source

H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis [PDF]

, 2002
dEndocytosis is required for efficient mitogen-activated protein kinase (MAPK) activation by activated growth factor receptors. We examined if H-Ras and K-Ras proteins, which are distributed across different plasma membrane microdomains, have equal ...
Hancock, J. F., Roy, S., Wyse, B.
core   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Dynamics of Ras Complexes Observed in Living Cells

Sensors, 2012
K-Ras works as a switch in many important intracellular signaling pathways and plays important roles in cell growth, proliferation, differentiation and carcinogenesis.
Xiangyong Li, Zhiyong Cheng, Honglin Jin
doaj   +1 more source

Peptides That Block RAS-p21 Protein-Induced Cell Transformation

Biomedicines, 2023
This is a review of approaches to the design of peptides and small molecules that selectively block the oncogenic RAS-p21 protein in ras-induced cancers. Single amino acid substitutions in this protein, at critical positions such as at Gly 12 and Gln 61,
Matthew R. Pincus, Bo Lin, Purvi Patel, Elmer Gabutan, Nitzan Zohar, Wilbur B. Bowne   +5 more
doaj   +1 more source