Results 101 to 110 of about 60,774,760 (242)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Muck & Magic Community Garden

open access: yes, 2013
Sustainable organic vegetables, fruit and herb production for distribution to the participants of the community garden. All Age Groups, throughout the Ballymun community Global Action Plan Initiative Type Community Food Growing Projects Location ...
Healthy Food For All
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Structured Fruit Cube Snack of BRS Vitoria Grape with Gala Apple: Phenolic Composition and Sensory Attributes

open access: yesMolecules
This study developed a structured fruit cube (FC) snack using only natural ingredients, specifically red grape and apple, without hydrocolloids and sucrose.
Yara Paula Nishiyama-Hortense   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Comorbid implications: how does ADD/ADHD affect college students vocationally and educationally? [PDF]

open access: yes, 2000
Plan BThe prevalence of Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder in college students and how it affects them vocationally and educationally was investigated.
Burgess, Jennifer L.
core  

Assessing tomato genetic improvement through physicochemical characterization and rapid sensory analysis as an alternative to traditional descriptive methods

open access: yesDiscover Food
Recently, rapid methods have emerged as promising tools for assessing fresh crops. This research aimed to compare two sensory methods for the evaluation of the Acorazado tomato hybrid resistant to Tomato yellow leaf curl virus (TYLCV) cultivated under ...
Natalia Barboza   +6 more
doaj   +1 more source

Physicochemical Properties, Sensory Profile, and Emotional Perception of Unpolished Organic Rice

open access: yesPolish Journal of Food and Nutrition Sciences
Incorporating unpolished rice into an everyday diet improves overall health and well-being. The objective of this study was to evaluate the physicochemical properties, sensory profiles, and emotional attributes of various unpolished organic rice ...
Hadi Munarko   +4 more
doaj   +1 more source

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