Results 91 to 100 of about 3,892,702 (296)
, 2006 This paper deals with order identification for nested models in the i.i.d. framework. We study the asymptotic efficiency of two generalized likelihood ratio tests of the order.
Chambaz, Antoine
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
A new kernel estimator of hazard ratio and its asymptotic mean squared error
, 2016 The hazard function is a ratio of a density and survival function, and it is a basic tool of the survival analysis. In this paper we propose a kernel estimator of the hazard ratio function, which are based on a modification of \'{C}wik and Mielniczuk's ...
Maesono, Yoshihiko, Moriyama, Taku
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Consequences of measurement error in qPCR telomere data: A simulation study.
PLoS ONE, 2019 The qPCR method provides an inexpensive, rapid method for estimating relative telomere length across a set of biological samples. Like all laboratory methods, it involves some degree of measurement error.
Daniel Nettle +4 more
doaj +1 more source
Error Exponents of Mismatched Likelihood Ratio Testing
, 2020 We study the problem of mismatched likelihood ratio test. We analyze the type-\RNum{1} and \RNum{2} error exponents when the actual distributions generating the observation are different from the distributions used in the test. We derive the worst-case error exponents when the actual distributions generating the data are within a relative entropy ball ...
Boroumand, Parham +1 more
openaire +3 more sources
Estimation of parameters in linear structural relationships: Sensitivity to the choice of the ratio of error variances [PDF]
Maximum likelihood estimation of parameters in linear structural relationships under normality assumptions requires knowledge of one or more of the model parameters if no replication is available.
Gunst, R. F., Lakshminarayanan, M. Y.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Studi Pengolah Data (Processinging) Seismik dengan Mengunakan Program Promax
Jurnal Fisika Flux, 2017 Pengolahan data seismik yang dilakukan bertujuan untuk memperoleh gambaran struktur geologi bawah permukaan yang mendekati keadaan sebenarnya dengan cara meningkatkan signal noise ratio.
Rahma Hi Manrulu +3 more
doaj +1 more source