Results 101 to 110 of about 1,393,722 (311)
Sources of error and bias in methods of fertility estimation contingent on the P/F ratio in a time of declining fertility and rising mortality [PDF]
Almost all commonly used indirect fertility estimation methods rely on the P/F ratio. As originally conceived, the ratio compares cumulated cohort fertility with cumulated period fertility on the basis of three, fairly strong, assumptions.
Tom Moultrie, Rob Dorrington
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Minimizing error in robot arm based on design optimization for high stiffness to weight ratio.
Al-Khawarizmi Engineering Journal, 2008 In this work the effect of choosing tri-circular tube section had been addressed to minimize the end effectors error, a comparison had been made between the tri-tube section and the traditional square cross section for a robot arm, the study shows that ...
Ahmed Abdul Hussain Ali
doaj +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Hadron ratio fluctuations in heavy-ion collisions
, 2012 The first measurement of the fluctuation of the kaon-to-proton ratio in relativistic heavy-ion collisions is presented. This thesis details the analysis procedure for identifying kaons and protons using the NA49 experiment at CERN-SPS and discusses the ...
Schuster, Tim
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
, 2001 The performance of $M$-ary orthogonal signaling schemes employing Reed–Solomon (RS) codes and redundant residue number system (RRNS) codes is investigated over frequency-selective Rayleigh fading channels.
Yang, L-L., Hanzo, L.
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A Score Test for Individual Heteroscedasticity in a One-way Error Components Model [PDF]
The purpose of this paper is to derive a Rao's efficient score statistic for testing for heteroscedasticity in an error components model with only individual effects. We assume that the individual effect exists and therefore do not test for it.
Lucien GARDIOL, Alberto HOLLY
core