Results 91 to 100 of about 3,914,003 (294)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Space-Time Equalisation Assisted Minimum Bit-Error Ratio Multiuser Detection for SDMA Systems
, 2005 This contribution investigates a space-time equalisation assisted multiuser detection scheme designed for multiple receiver antenna aided space division multiple access (SDMA) systems.
Chen, S., Hanzo, L., Yang, X.C.
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Consequences of measurement error in qPCR telomere data: A simulation study.
PLoS ONE, 2019 The qPCR method provides an inexpensive, rapid method for estimating relative telomere length across a set of biological samples. Like all laboratory methods, it involves some degree of measurement error.
Daniel Nettle +4 more
doaj +1 more source
Error Exponents of Mismatched Likelihood Ratio Testing
, 2020 We study the problem of mismatched likelihood ratio test. We analyze the type-\RNum{1} and \RNum{2} error exponents when the actual distributions generating the observation are different from the distributions used in the test. We derive the worst-case error exponents when the actual distributions generating the data are within a relative entropy ball ...
Boroumand, Parham +1 more
openaire +3 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Studi Pengolah Data (Processinging) Seismik dengan Mengunakan Program Promax
Jurnal Fisika Flux, 2017 Pengolahan data seismik yang dilakukan bertujuan untuk memperoleh gambaran struktur geologi bawah permukaan yang mendekati keadaan sebenarnya dengan cara meningkatkan signal noise ratio.
Rahma Hi Manrulu +3 more
doaj +1 more source
A performance comparison between block interleaved and helically interleaved concatenated coding systems [PDF]
The performance (bit-error rate vs. signal-to-noise ratio) of two different interleaving systems, block interleaving and the newer helical interleaving are compared. Both systems are studied with and without error forecasting.
Cheung, K.-M., Swanson, L.
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source