Results 91 to 100 of about 3,799,599 (344)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

INVITATION TO INTEGRAL AND RATIONAL POINTS ON CURVES AND SURFACES

open access: yes, 2014
We provide a basic short introduction to Diophantine Geometry focusing on solutions to polynomial equations that correspond to rational and integral point of curves and surfaces.
Turchet, Amos   +7 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

On the distribution of ramification points in trigonal curves

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1999
We study the distribution of the total and ordinary ramification points of a trigonal curve over the intersection of this curve with rational curves on a rational normal scroll.
Cícero F. Carvalho
doaj   +1 more source

Rational points on singular intersections of quadrics

open access: yes, 2013
Given an intersection of two quadrics X ⊂ ℙm-1, with m ≥ 9, the quantitative arithmetic of the set X(ℚ) is investigated under the assumption that the singular locus of consists of a pair of conjugate singular points defined over &#
Browning, T. D., Munshi, R.
core   +1 more source

Neural-Network-Based Curve Fitting Using Totally Positive Rational Bases

open access: yesMathematics, 2020
This paper proposes a method for learning the process of curve fitting through a general class of totally positive rational bases. The approximation is achieved by finding suitable weights and control points to fit the given set of data points using a ...
Rocio Gonzalez-Diaz   +3 more
doaj   +1 more source

The Hardy–Littlewood conjecture and rational points [PDF]

open access: yesCompositio Mathematica, 2014
Abstract Schinzel’s Hypothesis (H) was used by Colliot-Thélène and Sansuc, and later by Serre, Swinnerton-Dyer and others, to prove that the Brauer–Manin obstruction controls the Hasse principle and weak approximation on pencils of conics and similar varieties. We show that when the ground field is
Harpaz, J.   +2 more
openaire   +4 more sources

Evaluation of state integrals at rational points [PDF]

open access: yes, 2014
Multi-dimensional state-integrals of products of Faddeev's quantum dilogarithms arise frequently in Quantum Topology, quantum Teichm\"uller theory and complex Chern--Simons theory.
S. Garoufalidis, R. Kashaev
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

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