Results 81 to 90 of about 2,867,834 (292)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Evaluation of Drug Prescriptions for Geriatric Patients in a Tertiary Care Hospital using Phadke’s Criteria

Journal of Pharmaceutical Research
Polypharmacy is common among the elderly due to multiple comorbidities, increasing the risk of drug-drug interactions, toxicities, and adverse reactions.
Megha Naik, Smita Anand Tiwari, Sangeeta Dabhade   +2 more
doaj   +1 more source

ON THE RATIONAL POINTS ON CUBIC SURFACES [PDF]

Glasgow Mathematical Journal, 2000
Let \(N(P)\) denote the number of solutions in integers \(x_i\) with \(|x_i|\leq P\) of \(\sum_{1 \leq i \leq 4}a_ix_i^3 = 0\), in which \(a_i \neq 0\), and let \(N_1(P)\) denote the number of these solutions that do not lie on rational lines in the projective surface \(\mathcal S\) defined by this equation. \textit{D. R. Heath-Brown} [Philos. Trans. R.
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Interpolation method for quaternionic-Bezier curves

Lietuvos Matematikos Rinkinys, 2018
We study rational quaternionic-Bézier curves in three dimensional space. We construct the quadratic quaternionic-Bézier curve which interpolates five points, or three points and two tangent vectors.
Severinas Zube
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Arithmetic of rational points and zero-cycles on Kummer varieties

, 2018
Yongqi Liang has shown that for rationally connected varieties over a number field K, sufficiency of the Brauer-Manin obstruction to the existence of rational points over all finite extensions of K implies sufficiency of the Brauer-Manin obstruction to ...
Newton, Rachel
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Simultaneous rational periodic points of degree-2 rational maps [PDF]

, 2021
In this thesis, we study the dynamical behaviour of degree two rational maps of the form kx+b/x and quadratic polynomials with rational coefficients. Assuming standard conjectures on the period length of rational periodic points of these maps, we give ...
Barsakçı, Burcu
core   +1 more source