Results 61 to 70 of about 1,231,297 (284)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Rational and singular points of a family of curves

open access: yesResults in Applied Mathematics
This paper explores the properties of a family of absolutely irreducible projective plane curves, denoted Ca,b, which are defined over a finite field Fm of characteristic 2.
M.C. Rodríguez-Palánquex
doaj   +1 more source

Determination of rational drug use knowledge levels of adult Syrians under temporary protection applying to immigrant health centers in Malatya province and related factors

open access: yesMedicine Science, 2022
In this study, it was aimed to determine the rational drug use knowledge level of Syrians under temporary protection who applied to migrant health centers in Malatya province and related factors.
Deniz Yavuz Baskiran   +3 more
doaj   +1 more source

On Rational Points on Conics [PDF]

open access: yesProceedings of the American Mathematical Society, 1977
The purpose of this paper is to prove the following result: let K be a finitely, separably generated extension field of transcendence degree one and genus zero over the exact constant field k. Assume that K has no k-rational points. Let L be a subfield of K that contains k. Then L has a k-rational point if and only if [ K :
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

A Pseudospectral Algorithm for Solving Multipantograph Delay Systems on a Semi-Infinite Interval Using Legendre Rational Functions

open access: yesAbstract and Applied Analysis, 2014
A new Legendre rational pseudospectral scheme is proposed and developed for solving numerically systems of linear and nonlinear multipantograph equations on a semi-infinite interval. A Legendre rational collocation method based on Legendre rational-Gauss
E. H. Doha   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Counting rational points on a Grassmannian

open access: yes, 2020
We prove an estimate on the number of rational points on the Grassmannian variety of bounded twisted height, refining the classical result of Thunder ([21]) over the rational field: most importantly, our formula counts all points.
Kim, Seungki
core  

Rational Points on Diagonal Cubic Surfaces [PDF]

open access: yes, 2014
We show under the assumption that the Tate-Shafarevich group of any elliptic curve over the rational numbers is finite that the cubic surface $x_1^3 + p_1p_2x_2^3 + p_2p_3x_3^3 + p_3p_1x_4^3 = 0$ has a rational point, where $p_1, p_2$ and $p_3$ are ...
Sato, Kazuki
core   +2 more sources

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