Results 61 to 70 of about 2,867,834 (292)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Rational points on X0+(125) [PDF]
, 2023 We compute the rational points on the Atkin–Lehner quotient X0+(125) using the quadratic Chabauty method. Our work completes the study of exceptional rational points on the curves X0+(N) of genus between 2 and 6. Together with the work of several authors,
Vishal Arul +4 more
core +1 more source
Rational approximation of discrete data with asymptomatic behaviour [PDF]
This thesis is concerned with the least-squares approximation of discrete data that appear to exhibit asymptotic behaviour. In particular, we consider using rational functions as they are able to display a number of types of asymptotic behaviour.
Cooper, Philip
core +4 more sources
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
On the distribution of ramification points in trigonal curves
International Journal of Mathematics and Mathematical Sciences, 1999 We study the distribution of the total and ordinary ramification points of a trigonal curve over the intersection of this curve with rational curves on a rational normal scroll.
Cícero F. Carvalho
doaj +1 more source
The Hardy–Littlewood conjecture and rational points [PDF]
Compositio Mathematica, 2014 Abstract Schinzel’s Hypothesis (H) was used by Colliot-Thélène and Sansuc, and later by Serre, Swinnerton-Dyer and others, to prove that the Brauer–Manin obstruction controls the Hasse principle and weak approximation on pencils of conics and similar varieties. We show that when the ground field is
Harpaz, J. +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Abstract and Applied Analysis, 2014 A new Legendre rational pseudospectral scheme is proposed and developed for solving numerically systems of linear and nonlinear multipantograph equations on a semi-infinite interval. A Legendre rational collocation method based on Legendre rational-Gauss
E. H. Doha +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source