Results 111 to 120 of about 2,867,834 (292)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Reference Points and Effort Provision [PDF]

open access: yes
A key open question for theories of reference-dependent preferences is what determines the reference point. One candidate is expectations: what people expect could affect how they feel about what actually occurs.
Abeler, Johannes   +3 more
core   +2 more sources

INCREASING OPERATION EFFECTIVITY OF METAL PRODUCTS LOADING POINTS BY THE RATIONAL USE OF BRIDGE CRANES

open access: yesNauka ta progres transportu, 2019
Purpose. Taking into account research and improvement of transport and storage processes for loading railway cars with bridge cranes the purpose of the study is the analysis of actual crane operation zones, development of simulation models of their ...
S. M. Turpak   +3 more
doaj   +1 more source

Noncommutative Rational Double Points

open access: yesJournal of Algebra, 2000
Let \(k\) be an algebraically closed field of characteristic zero, let \(P=k\langle \langle u,v\rangle \rangle\) be the noncommutative power series ring in the two indeterminates \(u,v\), and \(r\in P\). Suppose that the leading term of \(r\) is quadratic with no linear factors. Then \(B=P/(r)\) is a regular ring of dimension two.
openaire   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Sieving for rational points on hyperelliptic curves [PDF]

open access: yes, 2001
We give a new and efficient method of sieving for rational points on hyperelliptic curves. This method is often successful in proving that a given hyperelliptic curve, suspected to have no rational points, does in fact have no rational points; we have
Siksek, Samir, Samir Siksek
core   +1 more source

Common fixed point theorems for generalized contraction involving rational expressions in complex valued metric spaces

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2015
The purpose of this paper is to study common fixed points in complex valued metric spaces and obtain sufficient conditions for the existence of common fixed points of a pair of mappings satisfying generalized contraction involving rational expressions.
Nashine Hemant Kumar, Fisher Brian
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

open access: yesFEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson   +2 more
wiley   +1 more source

Rational points on X_0^+ (p^r)

open access: yes, 2011
We show how the recent isogeny bounds due to É. Gaudron and G. Rémond allow to obtain the triviality of X_0^+ (p^r)(Q), for r>1 and p a prime exceeding 2.10^{11}. This includes the case of the curves X_split (p). We then prove, with the help of computer calculations, that the same holds true for p in the range 10 < p < 10^{14}, p\neq 13.
Bilu, Yu., Parent, Pierre, Rebolledo, M.
openaire   +5 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

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