Results 121 to 130 of about 2,867,834 (292)

Optimal spectroscopic measurement design: Bayesian framework for rational data acquisition

open access: yesMachine Learning: Science and Technology
We propose an optimal experimental design method for spectroscopic measurements that can determine the appropriate number and placement of measurement points in a rational manner.
Yusei Ito   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Improving Angular Speed Uniformity by Piecewise Radical Reparameterization

open access: yesElectronic Proceedings in Theoretical Computer Science
For a rational parameterization of a curve, it is desirable that its angular speed is as uniform as possible. Hence, given a rational parameterization, one wants to find re-parameterization with better uniformity.
Hong, Hoon, Wang, Dongming, Yang, Jing
doaj   +1 more source

A rational optimal block hybrid method for enhanced accuracy in solving Lane–Emden equations

open access: yesPartial Differential Equations in Applied Mathematics
This paper introduces a block hybrid method designed for the effective resolution of Lane–Emden equations, which are characterized as second-order boundary value problems incorporating a singularity at the origin.
Sandile Motsa   +3 more
doaj   +1 more source

Sliding look-ahead window-based real-time feedrate planning for non-uniform rational B-splines curves

open access: yesAdvances in Mechanical Engineering, 2018
This article presents an online three-axis non-uniform rational B-splines preprocessing and feedrate scheduling method with chord error, axial velocity, acceleration, and jerk limitations.
Jiankang Liu   +3 more
doaj   +1 more source

A conjecture on rational approximations to rational points

open access: yesJournal of Algebraic Geometry, 2006
In this paper, we examine how well a rational point P P on an algebraic variety
openaire   +2 more sources

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

open access: yesFEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton   +6 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

open access: yesFEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia   +9 more
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

open access: yesFEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla   +10 more
wiley   +1 more source

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