Results 121 to 130 of about 3,799,599 (344)
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Density of rational points on certain elliptic K3 surfaces
, 2019 We propose a 2-cover method to study rational points on elliptic surfaces. We apply it to several isotrivial Kummer-type families whose generic Mordell-Weil ranks are 0 so that geometric argument may fail and we show that for these families rational ...
Huang, Zhizhong
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Rational points over $C_1$-fields of characteristic 0
, 2019 In the 1950s Lang studied the properties of $C_1$ fields, that is, fields over which every hypersurface of degree at most $n$ in a projective space of dimension $n$ has a rational point.
Pieropan, Marta
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(G,F)-points on ℚ-algebraic varieties [PDF]
Notes on Number Theory and Discrete MathematicsLet ℚ be the field of rational numbers, and let C be an algebraically closed field containing ℚ. Let G ∈ ℚ[x,y,z] be a polynomial, then the zero set of G is Z(G) = {P ∈ Cⁿ | G(P) = 0}.
Yangcheng Li, Hongjian Li
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Noncommutative Rational Double Points
Journal of Algebra, 2000 Let \(k\) be an algebraically closed field of characteristic zero, let \(P=k\langle \langle u,v\rangle \rangle\) be the noncommutative power series ring in the two indeterminates \(u,v\), and \(r\in P\). Suppose that the leading term of \(r\) is quadratic with no linear factors. Then \(B=P/(r)\) is a regular ring of dimension two.
openaire +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Tensor product and irregularity for holonomic D-modules
, 2015 To appear at C. R. Acad. Sci. ParisLet M be a complex of D-modules with bounded holonomic cohomology on a complex manifold.
Teyssier, Jean-Baptiste
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