Results 131 to 140 of about 3,799,599 (344)
The rational points close to a curve II [PDF]
Acta Arithmetica, 2000 In the introduction to this paper, the author succinctly states the basic problem as follows: ``If a function \(f(x)\) takes values which are approximately rational at integer points or at rational points, is \(f(x)\) approximately a rational function?'' Alternatively, if \(f\) cannot be approximated over a long interval \([0,M]\) by a rational ...
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A Boundedness theorem for nearby slopes of holonomic D-modules
, 2015 Using twisted nearby cycles, we define a new notion of slopes for complex holonomic D-modules. We prove a boundedness result for these slopes, study their functoriality and use them to characterize regularity.
Teyssier, Jean-Baptiste
core
On Rational Maps with Two Critical Points [PDF]
Experimental Mathematics, 2000 59 pages, 18 PostScript ...
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FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Obstructions to existence of rational points on curves from subgroups of the Brauer group
, 2019 It is widely expected that, if a curve over a global field has no rational points, that there is an obstruction to existence of rational points coming from the Brauer group. One piece of evidence for this is an heuristic due to Poonen.
Voloch, Felipe
core
Rational Functions with Prescribed Critical Points [PDF]
Geometrical and Functional Analysis GAFA, 2002 A rational function is the ratio of two complex polynomials in one variable without common roots. Its degree is the maximum of the degrees of the numerator and the denominator. Rational functions belong to the same class if one turns into the other by the postcomposition with a linear-fractional transformation.
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Arithmetic of rational points and zero-cycles on Kummer varieties
, 2018 Yongqi Liang has shown that for rationally connected varieties over a number field K, sufficiency of the Brauer-Manin obstruction to the existence of rational points over all finite extensions of K implies sufficiency of the Brauer-Manin obstruction to ...
Newton, Rachel
core
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source