Results 1 to 10 of about 7,023 (110)

Inhalation of 1-bromopropane alters hippocampal expression of pathways related to immune system/inflammation and insulin signaling in experimental rats [PDF]

Scientific Reports
1-Bromopropane, an alternative to ozone-depleting solvents, exhibits neurotoxicity in humans and rats. The aim of the present study was to identify the genes or signaling pathways involved in the neurotoxicity and hepatotoxicity of 1-bomopropane in two ...
Fen Huang, Sahoko Ichihara, Ying Cheng, Wataru Fujibuchi, Emiko Kitagawa, Satomi Mizukami, Hitoshi Iwahashi, Sahabudeen Sheik Mohideen, Junzoh Kitoh, Seiichiroh Ohsako, Yousra Reda, Cai Zong, Gaku Ichihara   +12 more
doaj   +2 more sources

Hi-C sequencing data from frontal cortex of laboratory rats [PDF]

Scientific Data
The three-dimensional structure of chromosomes is integral to nuclear organization and influences processes such as DNA replication, repair, and gene expression.
Panjun Kim, Rachel R. Ward, Burt M. Sharp, Robert W. Williams, Hao Chen   +4 more
doaj   +2 more sources

Statement on the findings presented in the Toxicological Profile for Mercury issued by the US ATSDR. [PDF]

EFSA J
Abstract The European Food Safety Authority (EFSA) was requested by the European Commission to deliver a statement on the findings presented in the Toxicological Profile for Mercury issued by the US Agency for Toxic Substances and Disease Registry (ATSDR) in 2024. The statement was endorsed by the CONTAM Panel before approval by EFSA. Although some key
European Food Safety Authority (EFSA), Bastaki M, Eskes C, Halldorsson T, Muñoz Guajardo IP, Vejdovszky K, Viviani B, Steinkellner H.   +7 more
europepmc   +2 more sources

Influence of Age and Genetic Background on Ethanol Intake and Behavioral Response Following Ethanol Consumption and During Abstinence in a Model of Alcohol Abuse

Frontiers in Behavioral Neuroscience, 2022
Genetic background and age at first exposure have been identified as critical variables that contribute to individual vulnerability to drug addiction. Evidence shows that genetic factors may account for 40–70% of the variance in liability to addiction ...
Silvia Corongiu, Christian Dessì, Elena Espa, Augusta Pisanu, Annalisa Pinna, Daniele Lecca, Sandro Fenu, Cristina Cadoni   +7 more
doaj   +1 more source

Derivation of a germline competent transgenic Fischer 344 embryonic stem cell line. [PDF]

PLoS ONE, 2013
Embryonic stem (ES) cell-based gene manipulation is an effective method for the generation of mutant animal models in mice and rats. Availability of germline-competent ES cell lines from inbred rat strains would allow for creation of new genetically ...
Hongsheng Men, Elizabeth C Bryda
doaj   +1 more source

Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats [PDF]

Functional & Integrative Genomics, 2009
Previously, we identified the regions of chromosomes 10q12-q31 and 15p16-q21 harbor quantitative trait loci (QTLs) for lumbar volumetric bone mineral density (vBMD) in female F2 rats derived from Fischer 344 (F344) x Lewis (LEW) and Copenhagen 2331 (COP) x Dark Agouti (DA) crosses.
Imranul, Alam, Qiwei, Sun, Daniel L, Koller, Lixiang, Liu, Yunlong, Liu, Howard J, Edenberg, Tatiana, Foroud, Charles H, Turner   +7 more
openaire   +2 more sources

Marker tolerant, immunocompetent animals as a new tool for regenerative medicine and long-term cell tracking

BMC Biotechnology, 2007
Background Immune-mediated rejection of labeled cells is a general problem in transplantation studies using cells labeled with any immunogenic marker, and also in gene therapy protocols.
Sandgren Eric P, Weber Karin, Unger Nina J, Odörfer Kathrin I, Erben Reinhold G   +4 more
doaj   +1 more source

Lewis, Fischer 344, and Sprague-Dawley rats display differences in lipid peroxidation, motor recovery, and rubrospinal tract preservation after spinal cord injury.

Frontiers in Neurology, 2015
The rat is the most common animal model for the preclinical validation of neuroprotective therapies in spinal cord injury (SCI). Lipid peroxidation (LP) is a hallmark of the damage triggered after SCI.
Humberto eMestre, Manuel eRamirez, Elisa eGarcia, Elisa eGarcia, Susana eMartiñón, Yolanda eCruz, Maria G. Campos, Antonio eIbarra, Antonio eIbarra   +8 more
doaj   +1 more source

Inbred F344 rats as a biologic model of intra-abdominal sepsis

Brazilian Journal of Veterinary Research and Animal Science, 2002
Aiming to design a biologic model of acute intra-abdominal sepsis for experimental studies, conventional, isogenic rats F344 were infected with the bacteria Escherichia coli (E.coli), strain 11775, serotype H7:01:K1. Six hours after inoculation with E.
Damy, Sueli Blanes, Ebisui, Luci, Spinelli, Marilda Osti, Osaka, Junko Takano, Tolosa, Erasmo Magalhães Castro de, Ortiz, Silvia Colleta Barreto da Costa   +5 more
openaire   +3 more sources

Whole exome and transcript profiling of liver following aflatoxin B1 exposure in rats

Journal of Applied Toxicology, Volume 43, Issue 9, Page 1293-1305, September 2023., 2023
Abstract We recently developed a rat whole exome sequencing (WES) panel and used it to evaluate early somatic mutations in archival liver tissues from F344/N rats exposed to the hepatocarcinogen, Aflatoxin B1 (AFB1), a widely studied, potent mutagen and hepatocarcinogen associated with hepatocellular carcinoma (HCC).
Julie F. Foley, Brian Elgart, Dhiral Phadke, Deepak Mav, Ignacio Tripodi, Nicholas Clausen, Madeleine Weick, Wes Gladwell, Kevin Gerrish, Ruchir Shah, B. Alex Merrick   +10 more
wiley   +1 more source