Results 1 to 10 of about 8,257 (145)
Inbred F344 rats as a biologic model of intra-abdominal sepsis [PDF]
Brazilian Journal of Veterinary Research and Animal Science, 2002 Aiming to design a biologic model of acute intra-abdominal sepsis for experimental studies, conventional, isogenic rats F344 were infected with the bacteria Escherichia coli (E.coli), strain 11775, serotype H7:01:K1. Six hours after inoculation with E.
Damy, Sueli Blanes +5 more
openaire +7 more sources
Marker tolerant, immunocompetent animals as a new tool for regenerative medicine and long-term cell tracking [PDF]
BMC Biotechnology, 2007 Background Immune-mediated rejection of labeled cells is a general problem in transplantation studies using cells labeled with any immunogenic marker, and also in gene therapy protocols.
Sandgren Eric P +4 more
doaj +6 more sources
Frontiers in Behavioral Neuroscience, 2022 Genetic background and age at first exposure have been identified as critical variables that contribute to individual vulnerability to drug addiction. Evidence shows that genetic factors may account for 40–70% of the variance in liability to addiction ...
Silvia Corongiu +7 more
doaj +1 more source
Derivation of a germline competent transgenic Fischer 344 embryonic stem cell line. [PDF]
PLoS ONE, 2013 Embryonic stem (ES) cell-based gene manipulation is an effective method for the generation of mutant animal models in mice and rats. Availability of germline-competent ES cell lines from inbred rat strains would allow for creation of new genetically ...
Hongsheng Men, Elizabeth C Bryda
doaj +1 more source
Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats [PDF]
Functional & Integrative Genomics, 2009 Previously, we identified the regions of chromosomes 10q12-q31 and 15p16-q21 harbor quantitative trait loci (QTLs) for lumbar volumetric bone mineral density (vBMD) in female F2 rats derived from Fischer 344 (F344) x Lewis (LEW) and Copenhagen 2331 (COP) x Dark Agouti (DA) crosses.
Lixiang Liu +7 more
openaire +3 more sources
Population distribution profiles of the activities of blood alanine and aspartate aminotransferase in the normal F344 inbred rat by age and sex [PDF]
Laboratory Animals, 1991 Data on the blood enzyme activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were collected from control male and female F344 rats participating in toxicity studies at 17, 30, 56, 80 and 106 weeks of age. The data were skewed to the right with significant deviation from normality.
Rina Chen, Abraham Nyska, Trevor Waner
openaire +3 more sources
Local vs. systemic administration of bisphosphonates in rat cleft bone graft: A comparative study. [PDF]
PLoS ONE, 2018 A majority of patients with orofacial cleft deformity requires cleft repair through a bone graft. However, elevated amount of bone resorption and subsequent bone graft failure remains a significant clinical challenge.
Christine Hong +10 more
doaj +1 more source
Experimental rat models of chronic allograft nephropathy: a review [PDF]
, 2014 Chronic allograft nephropathy (CAN) is the leading cause of late allograft loss after renal transplantation (RT), which continues to remain an unresolved problem. A rat model of CAN was first described in 1969 by White et al. Although the rat model of RT
Haylor, John, Shrestha, Badri
core +2 more sources
Slc:Wistar outbred rats show close genetic similarity with F344 inbred rats
Experimental Animals, 2015 Although Slc:Wistar rats are used widely in biomedical research as outbred rats, close similarities in growth curves, survival rates, and immunological and biochemical phenotypes have been reported between Slc:Wistar and F344 inbred rats. We reported previously that nine genetic variations that were fixed in Slc:Wistar rats had identical genotypes in ...
Tadao Serikawa +3 more
openaire +4 more sources
Frontiers in Neurology, 2015 The rat is the most common animal model for the preclinical validation of neuroprotective therapies in spinal cord injury (SCI). Lipid peroxidation (LP) is a hallmark of the damage triggered after SCI.
Humberto eMestre +8 more
doaj +1 more source