Results 1 to 10 of about 8,920 (159)

Inbred F344 rats as a biologic model of intra-abdominal sepsis [PDF]

Brazilian Journal of Veterinary Research and Animal Science, 2002
Aiming to design a biologic model of acute intra-abdominal sepsis for experimental studies, conventional, isogenic rats F344 were infected with the bacteria Escherichia coli (E.coli), strain 11775, serotype H7:01:K1. Six hours after inoculation with E.
Damy, Sueli Blanes, Ebisui, Luci, Spinelli, Marilda Osti, Osaka, Junko Takano, Tolosa, Erasmo Magalhães Castro de, Ortiz, Silvia Colleta Barreto da Costa   +5 more
openaire   +7 more sources

Marker tolerant, immunocompetent animals as a new tool for regenerative medicine and long-term cell tracking [PDF]

BMC Biotechnology, 2007
Background Immune-mediated rejection of labeled cells is a general problem in transplantation studies using cells labeled with any immunogenic marker, and also in gene therapy protocols.
Sandgren Eric P, Weber Karin, Unger Nina J, Odörfer Kathrin I, Erben Reinhold G   +4 more
doaj   +6 more sources

Salivary α-amylase exhibits antiproliferative effects in primary cell cultures of rat mammary epithelial cells and human breast cancer cells [PDF]

Journal of Experimental & Clinical Cancer Research, 2011
Background Breast cancer is one of the most diagnosed cancers in females, frequently with fatal outcome, so that new strategies for modulating cell proliferation in the mammary tissue are urgently needed.
Bertram Catharina, Hass Ralf, Fedrowitz Maren, Löscher Wolfgang   +3 more
doaj   +3 more sources

Efficient gene targeting by homologous recombination in rat embryonic stem cells. [PDF]

PLoS ONE, 2010
The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombination.
Stephen Meek, Mia Buehr, Linda Sutherland, Alison Thomson, John J Mullins, Andrew J Smith, Tom Burdon   +6 more
doaj   +6 more sources

Comparison of Thermal and Mechanical Pain Testing Modalities in Sprague Dawley and Fischer 344 Rats (<i>Rattus norvegicus</i>). [PDF]

Comp Med
While rodents are used extensively for studying pain, there is a lack of reported direct comparisons of thermal and mechanical pain testing methods in rats of different genetic backgrounds.
McNew JF, Davis DJ, Grimsrud KN, Bryda EC.   +3 more
europepmc   +3 more sources

A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats. [PDF]

Cell Genom
The seventh iteration of the reference genome assembly for Rattus norvegicus-mRatBN7.2-corrects numerous misplaced segments and reduces base-level errors by approximately 9-fold and increases contiguity by 290-fold compared with its predecessor.
de Jong TV, Pan Y, Rastas P, Munro D, Tutaj M, Akil H, Benner C, Chen D, Chitre AS, Chow W, Colonna V, Dalgard CL, Demos WM, Doris PA, Garrison E, Geurts AM, Gunturkun HM, Guryev V, Hourlier T, Howe K, Huang J, Kalbfleisch T, Kim P, Li L, Mahaffey S, Martin FJ, Mohammadi P, Ozel AB, Polesskaya O, Pravenec M, Prins P, Sebat J, Smith JR, Solberg Woods LC, Tabakoff B, Tracey A, Uliano-Silva M, Villani F, Wang H, Sharp BM, Telese F, Jiang Z, Saba L, Wang X, Murphy TD, Palmer AA, Kwitek AE, Dwinell MR, Williams RW, Li JZ, Chen H.   +50 more
europepmc   +3 more sources

Influence of Age and Genetic Background on Ethanol Intake and Behavioral Response Following Ethanol Consumption and During Abstinence in a Model of Alcohol Abuse

Frontiers in Behavioral Neuroscience, 2022
Genetic background and age at first exposure have been identified as critical variables that contribute to individual vulnerability to drug addiction. Evidence shows that genetic factors may account for 40–70% of the variance in liability to addiction ...
Silvia Corongiu, Christian Dessì, Elena Espa, Augusta Pisanu, Annalisa Pinna, Daniele Lecca, Sandro Fenu, Cristina Cadoni   +7 more
doaj   +1 more source

Neuroimaging reveals distinct brain glucose metabolism patterns associated with morphine consumption in Lewis and Fischer 344 rat strains. [PDF]

, 2022
Vulnerability to addiction may be given by the individual's risk of developing an addiction during their lifetime. A challenge in the neurobiology of drug addiction is understanding why some people become addicted to drugs.
Ambrosio, Emilio, Desco, Manuel, García-Vázquez, Verónica, Lamanna-Rama, Nicolás, López-Montoya, Gonzalo, Soto-Montenegro, Mª Luisa   +5 more
core   +2 more sources

Derivation of a germline competent transgenic Fischer 344 embryonic stem cell line. [PDF]

PLoS ONE, 2013
Embryonic stem (ES) cell-based gene manipulation is an effective method for the generation of mutant animal models in mice and rats. Availability of germline-competent ES cell lines from inbred rat strains would allow for creation of new genetically ...
Hongsheng Men, Elizabeth C Bryda
doaj   +1 more source

Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats [PDF]

Functional & Integrative Genomics, 2009
Previously, we identified the regions of chromosomes 10q12-q31 and 15p16-q21 harbor quantitative trait loci (QTLs) for lumbar volumetric bone mineral density (vBMD) in female F2 rats derived from Fischer 344 (F344) x Lewis (LEW) and Copenhagen 2331 (COP) x Dark Agouti (DA) crosses.
Lixiang Liu, Howard J. Edenberg, Charles H. Turner, Tatiana Foroud, Imranul Alam, Daniel L. Koller, Qiwei Sun, Yunlong Liu   +7 more
openaire   +3 more sources