Results 1 to 10 of about 52 (45)
Population distribution profiles of the activities of blood alanine and aspartate aminotransferase in the normal F344 inbred rat by age and sex [PDF]
Laboratory Animals, 1991 Data on the blood enzyme activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were collected from control male and female F344 rats participating in toxicity studies at 17, 30, 56, 80 and 106 weeks of age. The data were skewed to the right with significant deviation from normality.
Trevor Waner, A Nyska
exaly +3 more sources
Slc:Wistar outbred rats show close genetic similarity with F344 inbred rats
Experimental Animals, 2015 Although Slc:Wistar rats are used widely in biomedical research as outbred rats, close similarities in growth curves, survival rates, and immunological and biochemical phenotypes have been reported between Slc:Wistar and F344 inbred rats. We reported previously that nine genetic variations that were fixed in Slc:Wistar rats had identical genotypes in ...
Satoshi Nakanishi, Takashi Kuramoto
exaly +4 more sources
Frontiers in Behavioral Neuroscience, 2022 Genetic background and age at first exposure have been identified as critical variables that contribute to individual vulnerability to drug addiction. Evidence shows that genetic factors may account for 40–70% of the variance in liability to addiction ...
Silvia Corongiu +7 more
doaj +1 more source
Derivation of a germline competent transgenic Fischer 344 embryonic stem cell line. [PDF]
PLoS ONE, 2013 Embryonic stem (ES) cell-based gene manipulation is an effective method for the generation of mutant animal models in mice and rats. Availability of germline-competent ES cell lines from inbred rat strains would allow for creation of new genetically ...
Hongsheng Men, Elizabeth C Bryda
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Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats [PDF]
Functional & Integrative Genomics, 2009 Previously, we identified the regions of chromosomes 10q12-q31 and 15p16-q21 harbor quantitative trait loci (QTLs) for lumbar volumetric bone mineral density (vBMD) in female F2 rats derived from Fischer 344 (F344) x Lewis (LEW) and Copenhagen 2331 (COP) x Dark Agouti (DA) crosses.
Imranul, Alam +7 more
openaire +2 more sources
BMC Biotechnology, 2007 Background Immune-mediated rejection of labeled cells is a general problem in transplantation studies using cells labeled with any immunogenic marker, and also in gene therapy protocols.
Sandgren Eric P +4 more
doaj +1 more source
Frontiers in Neurology, 2015 The rat is the most common animal model for the preclinical validation of neuroprotective therapies in spinal cord injury (SCI). Lipid peroxidation (LP) is a hallmark of the damage triggered after SCI.
Humberto eMestre +8 more
doaj +1 more source
Inbred F344 rats as a biologic model of intra-abdominal sepsis
Brazilian Journal of Veterinary Research and Animal Science, 2002 Aiming to design a biologic model of acute intra-abdominal sepsis for experimental studies, conventional, isogenic rats F344 were infected with the bacteria Escherichia coli (E.coli), strain 11775, serotype H7:01:K1. Six hours after inoculation with E.
Damy, Sueli Blanes +5 more
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Frontiers in Neuroscience, 2018 The transgenic rat model of Huntington disease expressing a fragment of mutant HTT (tgHD rat) has been thoroughly characterized and reproduces hallmark symptoms of human adult-onset HD.
Anne-Christine Plank +11 more
doaj +1 more source
The FASEB Journal, 2012 Genetic background has a major influence on the severity of renovascular disease. Previously we showed that Lewis rats with inducible hypertension caused by transgenic renin expression have lower blood pressure, higher renal plasma flow (RPF) and glomerular filtration rate (GFR) and are relatively protected from hypertensive renal microvascular injury ...
Robert Ian Menzies +3 more
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