Results 1 to 10 of about 37 (37)

Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats [PDF]

Functional & Integrative Genomics, 2009
Previously, we identified the regions of chromosomes 10q12-q31 and 15p16-q21 harbor quantitative trait loci (QTLs) for lumbar volumetric bone mineral density (vBMD) in female F2 rats derived from Fischer 344 (F344) x Lewis (LEW) and Copenhagen 2331 (COP) x Dark Agouti (DA) crosses.
Lixiang Liu, Howard J. Edenberg, Charles H. Turner, Tatiana Foroud, Imranul Alam, Daniel L. Koller, Qiwei Sun, Yunlong Liu   +7 more
openaire   +3 more sources

Population distribution profiles of the activities of blood alanine and aspartate aminotransferase in the normal F344 inbred rat by age and sex [PDF]

Laboratory Animals, 1991
Data on the blood enzyme activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were collected from control male and female F344 rats participating in toxicity studies at 17, 30, 56, 80 and 106 weeks of age. The data were skewed to the right with significant deviation from normality.
Rina Chen, Abraham Nyska, Trevor Waner
openaire   +3 more sources

Whole exome and transcript profiling of liver following aflatoxin B1 exposure in rats

Journal of Applied Toxicology, Volume 43, Issue 9, Page 1293-1305, September 2023., 2023
Abstract We recently developed a rat whole exome sequencing (WES) panel and used it to evaluate early somatic mutations in archival liver tissues from F344/N rats exposed to the hepatocarcinogen, Aflatoxin B1 (AFB1), a widely studied, potent mutagen and hepatocarcinogen associated with hepatocellular carcinoma (HCC).
Julie F. Foley, Brian Elgart, Dhiral Phadke, Deepak Mav, Ignacio Tripodi, Nicholas Clausen, Madeleine Weick, Wes Gladwell, Kevin Gerrish, Ruchir Shah, B. Alex Merrick   +10 more
wiley   +1 more source

Advanced models for respiratory disease and drug studies

Medicinal Research Reviews, Volume 43, Issue 5, Page 1470-1503, September 2023., 2023
Abstract The global burden of respiratory diseases is enormous, with many millions of people suffering and dying prematurely every year. The global COVID‐19 pandemic witnessed recently, along with increased air pollution and wildfire events, increases the urgency of identifying the most effective therapeutic measures to combat these diseases even ...
Jesus Shrestha, Keshav Raj Paudel, Hojjatollah Nazari, Vivek Dharwal, Sajad Razavi Bazaz, Matt D. Johansen, Kamal Dua, Philip M. Hansbro, Majid Ebrahimi Warkiani   +8 more
wiley   +1 more source

A novel inducible haematopoietic cell‐depleting mouse model for chimeric complementation of blood cells

Cell Proliferation, Volume 56, Issue 5, May 2023., 2023
We established a novel inducible haematopoietic cell‐depleting mouse model and tested the feasibility of using chimeric complementation to regenerate HSCs and their progeny cells. Large populations of syngeneic and major histocompatibility‐mismatched haematopoietic cells were successfully regenerated by this model.
Weiyun Cao, Jiani Cao, Xing Li, Haoyu Xu, Jiayi Tian, Xiaoyan Li, Fengchao Wang, Tongbiao Zhao   +7 more
wiley   +1 more source

Revisiting the testicular toxicity of cyanide: Assessment of the new and existing literature

Birth Defects Research, Volume 115, Issue 7, Page 687-709, April 15, 2023., 2023
Abstract Background Based on new testing, we re‐assess U.S. EPA and California OEHHA conclusions regarding male reproductive toxicity associated with cyanide exposure. Methods Literature identified by ATSDR, ECETOC and EPA was complemented by studies conducted after 2006. Relevant studies were scored for quality using ToxRTool. Results Eleven pertinent
Amy Lavin Williams, John M. DeSesso
wiley   +1 more source

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

EFSA Journal, Volume 21, Issue 4, April 2023., 2023
Abstract In 2015, EFSA established a temporary tolerable daily intake (t‐TDI) for BPA of 4 μg/kg body weight (bw) per day. In 2016, the European Commission mandated EFSA to re‐evaluate the risks to public health from the presence of BPA in foodstuffs and to establish a tolerable daily intake (TDI). For this re‐evaluation, a pre‐established protocol was
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Andrew Chesson, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Vittorio Silano (until 21 December 2020†), Inger‐Lise Steffensen, Christina Tlustos, Laurence Vernis, Holger Zorn, Monika Batke, Margherita Bignami, Emanuela Corsini, Rex FitzGerald, Ursula Gundert‐Remy, Thorhallur Halldorsson, Andrew Hart, Evangelia Ntzani, Eugenio Scanziani, Henri Schroeder, Beate Ulbrich, Dina Waalkens‐Berendsen, Detlef Woelfle, Zainab Al Harraq, Katleen Baert, Maria Carfì, Anna F Castoldi, Cristina Croera, Henk Van Loveren   +37 more
wiley   +1 more source

Development of adverse outcome pathways relevant for the identification of substances having endocrine disruption properties Uterine adenocarcinoma as adverse outcome

EFSA Journal, Volume 21, Issue 2, February 2023., 2023
Abstract Development of adverse outcome pathways (AOPs) for uterine adenocarcinoma can provide a practical tool to implement the EFSA‐ECHA Guidance (2018) for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009.
EFSA Panel on Plant Protection Products and their Residues (PPR), Antonio F Hernandez‐Jerez, Paulien Adriaanse, Annette Aldrich, Philippe Berny, Tamara Coja, Sabine Duquesne, Andreas Focks, Maurice Millet, Olavi Pelkonen, Silvia Pieper, Aaldrik Tiktak, Christopher J Topping, Anneli Widenfalk, Martin Wilks, Gerrit Wolterink, Karine Angeli, Camilla Recordati, Majorie Van Duursen, Elisa Aiassa, Anna Lanzoni, Alfonso Lostia, Laura Martino, Irene Pilar Munoz Guajardo, Martina Panzarea, Andrea Terron, Marina Marinovich   +26 more
wiley   +1 more source

Slc:Wistar outbred rats show close genetic similarity with F344 inbred rats

Experimental Animals, 2015
Although Slc:Wistar rats are used widely in biomedical research as outbred rats, close similarities in growth curves, survival rates, and immunological and biochemical phenotypes have been reported between Slc:Wistar and F344 inbred rats. We reported previously that nine genetic variations that were fixed in Slc:Wistar rats had identical genotypes in ...
Tadao Serikawa, Tadao Serikawa, Takashi Kuramoto, S Nakanishi   +3 more
openaire   +4 more sources

Cysteine restriction‐specific effects of sulfur amino acid restriction on lipid metabolism

Aging Cell, Volume 21, Issue 12, December 2022., 2022
The proposed mechanism of CR‐specific effects of SAAR on adipose metabolism. (1) Due to the lack of Cys in SAAR diets, it imposes both MR and CR. CR specifically results in decreased biosynthesis of the tripeptide glutathione. (2) Lower hepatic glutathione increases the abundance of the transcription factor Nrf2, which translocates to the nucleus and ...
Sailendra N. Nichenametla, Dwight A. L. Mattocks, Diana Cooke, Vishal Midya, Virginia L. Malloy, Wilfredo Mansilla, Bente Øvrebø, Cheryl Turner, Nasser E. Bastani, Jitka Sokolová, Markéta Pavlíková, John P. Richie Jr., Anna K. Shoveller, Helga Refsum, Thomas Olsen, Kathrine J. Vinknes, Viktor Kožich, Gene P. Ables   +17 more
wiley   +1 more source