Results 1 to 10 of about 721,087 (130)
Hypoglossal and lumbar motor neuron death in old Sprague-Dawley rats. [PDF]
Physiol RepHypoglossal and lumbar motor neurons (MNs) surival is essential for maintiaining neuromotor health into old age. We observed loss of predominantly larger hypoglossal and lumbar MNs in 24 compared to 6 months old Sprague‐Dawley rats. This shows MN loss in old age is common between rat strains and is similar to elderly humans.
Cheung SW +4 more
europepmc +2 more sources
The evidence for old age motor neuron death: A scoping review. [PDF]
Physiol RepWe systematically evaluated the extant literature on age‐related motor neuron (MN) death in aging, focusing on studies directly assessing MNs. We show that in the spinal cord and brainstem, there is robust evidence for MN loss, particularly in the human spinal cord. In rats, MN loss was readily observed across a variety of labelling methods and regions,
Cheung SW, Fogarty MJ.
europepmc +2 more sources
Inhalation of 1-bromopropane alters hippocampal expression of pathways related to immune system/inflammation and insulin signaling in experimental rats [PDF]
Scientific Reports1-Bromopropane, an alternative to ozone-depleting solvents, exhibits neurotoxicity in humans and rats. The aim of the present study was to identify the genes or signaling pathways involved in the neurotoxicity and hepatotoxicity of 1-bomopropane in two ...
Fen Huang +12 more
doaj +2 more sources
Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats. [PDF]
Aging CellUsing genetically heterogeneous rats carrying divergent mitochondrial haplotypes on a randomized nuclear background, we show that mtDNA variation modifies the rate of ovarian aging. OKC‐HETW ovaries showed bioenergetic deficits, reduced mtDNA copy number, and impaired TFAM–mtDNA binding by 4 months of age, with early fibrosis and immune infiltration ...
Biswas S +11 more
europepmc +2 more sources
Statement on the findings presented in the Toxicological Profile for Mercury issued by the US ATSDR. [PDF]
EFSA JAbstract The European Food Safety Authority (EFSA) was requested by the European Commission to deliver a statement on the findings presented in the Toxicological Profile for Mercury issued by the US Agency for Toxic Substances and Disease Registry (ATSDR) in 2024. The statement was endorsed by the CONTAM Panel before approval by EFSA. Although some key
European Food Safety Authority (EFSA) +7 more
europepmc +2 more sources
Hi-C sequencing data from frontal cortex of laboratory rats [PDF]
Scientific DataThe three-dimensional structure of chromosomes is integral to nuclear organization and influences processes such as DNA replication, repair, and gene expression.
Panjun Kim +4 more
doaj +2 more sources
Frontiers in Behavioral Neuroscience, 2022 Genetic background and age at first exposure have been identified as critical variables that contribute to individual vulnerability to drug addiction. Evidence shows that genetic factors may account for 40–70% of the variance in liability to addiction ...
Silvia Corongiu +7 more
doaj +1 more source
Derivation of a germline competent transgenic Fischer 344 embryonic stem cell line. [PDF]
PLoS ONE, 2013 Embryonic stem (ES) cell-based gene manipulation is an effective method for the generation of mutant animal models in mice and rats. Availability of germline-competent ES cell lines from inbred rat strains would allow for creation of new genetically ...
Hongsheng Men, Elizabeth C Bryda
doaj +1 more source
BMC Biotechnology, 2007 Background Immune-mediated rejection of labeled cells is a general problem in transplantation studies using cells labeled with any immunogenic marker, and also in gene therapy protocols.
Sandgren Eric P +4 more
doaj +1 more source
Frontiers in Neurology, 2015 The rat is the most common animal model for the preclinical validation of neuroprotective therapies in spinal cord injury (SCI). Lipid peroxidation (LP) is a hallmark of the damage triggered after SCI.
Humberto eMestre +8 more
doaj +1 more source