Results 31 to 40 of about 22,238 (163)

Expression of an anti-CD4 single-chain antibody fragment from the donor cornea can prolong corneal allograft survival in inbred rats [PDF]

, 2012
To investigate whether expression of an anti-CD4 antibody fragment (scFv) by a lentivector-transduced donor cornea can prolong rat corneal allograft survival.
Appleby, Sarah Louise, Brereton, Helen Mary, Coster, Douglas John, Jessup, Claire Frances, Kirk, Kirsty, Mortimer, Lauren A, Tan, Chuan K, Williams, Keryn Anne   +7 more
core   +1 more source

Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity. [PDF]

, 2016
Severe, repeated or chronic stress produces negative health outcomes including disruptions of the sleep/wake cycle and gut microbial dysbiosis. Diets rich in prebiotics and glycoproteins impact the gut microbiota and may increase gut microbial species ...
Berg, Brian M, Chichlowski, Maciej, Fleshner, Monika, Greenwood, Benjamin N, Knight, Rob, Mika, Agnieszka, Roller, Rachel, Thompson, Robert S   +7 more
core   +1 more source

High-resolution genome screen for bone mineral density in heterogeneous stock rat [PDF]

, 2014
We previously demonstrated that skeletal mass, structure, and biomechanical properties vary considerably in heterogeneous stock (HS) rat strains. In addition, we observed strong heritability for several of these skeletal phenotypes in the HS rat model ...
Alam, Imranul, Baud, Amelie, Blázquez, Gloria, Cañete, Toni, Dieze, Margarita, Díaz-Morán, Sira, Econs, Michael J., Fernández-Teruel, Alberto, Foroud, Tatiana, Johannesson, Martina, Koller, Daniel L., López-Aumatell, Regina, Martínez-Membrives, Esther, Olsson, Tomas, Stridh, Pernilla, Tobeña, Adolf   +15 more
core   +1 more source

Effects of Amphetamine on Striatal Dopamine Release, Open-Field Activity, and Play in Fischer 344 and Sprague–Dawley Rats

, 2015
Previous work from our laboratories has shown that juvenile Fischer 344 (F344) rats are less playful than other strains and also appear to be compromised in dopamine (DA) functioning.
Akopian, Garnik, Eck, Samantha R., McDowell, Lana S., Siviy, Stephen M., Turano, Alexandra, Walsh, John P.   +5 more
core   +1 more source

Effect of photoperiodicity in the pregnancy rate of isogenic rats (F344) [PDF]

, 2011
O uso de animais isogênicos apresenta grandes vantagens experimentais, como uniformidade fenotípica e genotípica (reduzindo o número de animais em experimentos) e histocompatibilidade, permitindo, assim, o acúmulo de informações e a repetibilidade dos ...
Alves, Alexandre José, Alves, Flávio Ribeiro, Baptista, Alexandre Bastos, Ferreira, Amanda Olivotti, Guerra, Ricardo Romão, Miglino, Maria Angélica, Morita, Erika Lissa, Passos, Cristiane Carlin   +7 more
core   +2 more sources

Whole-Genome Sequences of DA and F344 Rats with Different Susceptibilities to Arthritis, Autoimmunity, Inflammation and Cancer

Genetics, 2013
DA (D-blood group of Palm and Agouti, also known as Dark Agouti) and F344 (Fischer) are two inbred rat strains with differences in several phenotypes, including susceptibility to autoimmune disease models and inflammatory responses.
Xiaosen Guo, M. Brenner, Xuemei Zhang, T. Laragione, S. Tai, Yanhong Li, Junjie Bu, Ye Yin, Anish A. Shah, K. Kwan, Yingrui Li, Wang Jun, P. Gulko   +12 more
semanticscholar   +1 more source

Cutaneous photosensitivity of phototheranostic porphyrin–lipid nanoparticles

Photochemistry and Photobiology, Volume 101, Issue 6, Page 1541-1558, November/December 2025.
Porphyrin‐lipid nanoparticles (PORPHYSOMES) exhibit significantly less severe and shorter‐lasting skin photosensitivity to sunlight compared to a therapeutically equivalent dose of porfimer sodium (PHOTOFRIN) in a rat skin model. The difference was due to altered intradermal distribution and faster clearance of PORPHYSOMES from skin after intravenous ...
Michael S. Valic, Mark Zheng, Theo Husby, Keegan Guidolin, Axel Sahovaler, Sharon Tzelnick, Wenlei Jiang, Michael Halim, Pamela Schimmer, Abdullah El‐Sayes, Chris J. Zhang, Tina Ye, Ivan Kosik, Jason L. Townson, Kenneth K. Ng, Lili Ding, Juan Chen, Jonathan C. Irish, Robert Weersink, Brian C. Wilson, Gang Zheng   +20 more
wiley   +1 more source

Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats

Aging Cell, Volume 24, Issue 8, August 2025.
Cardiorespiratory fitness (CRF) is not associated with epigenetic clocks, including newly developed ones. On the other hand, CRF is associated with global methylation profiles and promoter methylation in organ‐specific and organ‐common manner. ABSTRACT Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a ...
Takuji Kawamura, Csaba Kerepesi, Juliet Polok Sarkar, Ferenc Torma, Zoltan Bori, Lei Zhou, Peter Bakonyi, Attila Kolonics, Laszlo Balogh, Mitsuru Higuchi, Vivien Pillár, Karolina Pircs, Lauren Gerard Koch, Steven Loyal Britton, Erika Koltai, Zsolt Radak   +15 more
wiley   +1 more source

Stress Alters the Discriminative Stimulus and Response Rate Effects of Cocaine Differentially in Lewis and Fischer Inbred Rats

Behavioral Science, 2012
Stress enhances the behavioral effects of cocaine, perhaps via hypothalamic-pituitary-adrenal (HPA) axis activity. Yet, compared to Fischer 344 (F344) rats, Lewis rats have hyporesponsive HPA axis function and more readily acquire cocaine self ...
T. Kosten, Mindy J. D. Miserendino
semanticscholar   +1 more source

Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution?

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aim Antiretroviral therapy (ART) has reduced human immunodeficiency virus (HIV)/AIDS to a manageable chronic condition even though no cure exists. Despite ART control, latent HIV infection results in failed memory CD4 T‐cell responses, immune overactivation, inflammation, oxidative stress, genomic instability, deoxyribonucleic ...
Esimebia Adjovi Amegashie, Ruth Oyawole Sikeola, Emmanuel Ayitey Tagoe, Elijah Paintsil, Kwasi Torpey, Osbourne Quaye   +5 more
wiley   +1 more source