Results 41 to 50 of about 22,161 (167)

Stress Alters the Discriminative Stimulus and Response Rate Effects of Cocaine Differentially in Lewis and Fischer Inbred Rats

Behavioral Science, 2012
Stress enhances the behavioral effects of cocaine, perhaps via hypothalamic-pituitary-adrenal (HPA) axis activity. Yet, compared to Fischer 344 (F344) rats, Lewis rats have hyporesponsive HPA axis function and more readily acquire cocaine self ...
T. Kosten, Mindy J. D. Miserendino
semanticscholar   +1 more source

Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats

Aging Cell, Volume 24, Issue 8, August 2025.
Cardiorespiratory fitness (CRF) is not associated with epigenetic clocks, including newly developed ones. On the other hand, CRF is associated with global methylation profiles and promoter methylation in organ‐specific and organ‐common manner. ABSTRACT Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a ...
Takuji Kawamura, Csaba Kerepesi, Juliet Polok Sarkar, Ferenc Torma, Zoltan Bori, Lei Zhou, Peter Bakonyi, Attila Kolonics, Laszlo Balogh, Mitsuru Higuchi, Vivien Pillár, Karolina Pircs, Lauren Gerard Koch, Steven Loyal Britton, Erika Koltai, Zsolt Radak   +15 more
wiley   +1 more source

Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution?

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aim Antiretroviral therapy (ART) has reduced human immunodeficiency virus (HIV)/AIDS to a manageable chronic condition even though no cure exists. Despite ART control, latent HIV infection results in failed memory CD4 T‐cell responses, immune overactivation, inflammation, oxidative stress, genomic instability, deoxyribonucleic ...
Esimebia Adjovi Amegashie, Ruth Oyawole Sikeola, Emmanuel Ayitey Tagoe, Elijah Paintsil, Kwasi Torpey, Osbourne Quaye   +5 more
wiley   +1 more source

Photoperiod influences visceral adiposity and the adipose molecular clock independent of temperature in wild‐derived Peromyscus leucopus

FASEB BioAdvances, Volume 7, Issue 5, May 2025.
Physiology is closely synchronized to daily and seasonal light/dark cycles. Wild‐derived white‐footed mice were housed in long‐day (LD – 16L:8D) or short‐day (SD – 8L:16D) photoperiods at thermoneutrality (27°C). LD selectively increased visceral WAT mass and decreased Adrβ3 and Ucp1 expression while inducing misalignment of clock genes compared to SD.
Margaret E. Newport, Paul Wilson, Shanna Lowes, Marthe Behrends, Alexis Coons, Jeff Bowman, Holly E. Bates   +6 more
wiley   +1 more source

Gene-dosage- and sex-dependent differences in the prodromal-Like phase of the F344tgHD rat model for Huntington disease

Frontiers in Neuroscience
In Huntington disease (HD) the prodromal phase has been increasingly investigated and is currently in focus for early interventional treatments. Also, the influence of sex on disease progression and severity in patients is under discussion, as a sex ...
Veronika Ratz-Wirsching, Veronika Ratz-Wirsching, Johanna Habermeyer, Johanna Habermeyer, Sandra Moceri, Julia Harrer, Christoph Schmitz, Stephan von Hörsten, Stephan von Hörsten   +8 more
doaj   +1 more source

Genetic Loci Influencing Cue‐Reactivity in Heterogeneous Stock Rats

Genes, Brain and Behavior, Volume 24, Issue 2, April 2025.
A genome‐wide association study characterizing individual differences in cue‐reactivity (sign‐tracking; A) identifies multiple genetic loci, particularly on chromosomes 1 and 18 (B). Multiple candidate genes in these regions were identified, including those with known psychiatric relevance (e.g., Tenm4; C) and novel candidates with heritable ...
Christopher P. King, Apurva S. Chitre, Joel D. Leal‐Gutiérrez, Jordan A. Tripi, Alesa H. Netzley, Aidan P. Horvath, Alexander C. Lamparelli, Anthony George, Connor Martin, Celine L. St. Pierre, Thiago Missfeldt Sanches, Hannah V. Bimschleger, Jianjun Gao, Riyan Cheng, Khai‐Minh Nguyen, Katie L. Holl, Oksana Polesskaya, Keita Ishiwari, Hao Chen, Terry E. Robinson, Shelly B. Flagel, Leah C. Solberg Woods, Abraham A. Palmer, Paul J. Meyer   +23 more
wiley   +1 more source

Fetal-Adult Cardiac Transcriptome Analysis in Rats with Contrasting Left Ventricular Mass Reveals New Candidates for Cardiac Hypertrophy [PDF]

, 2015
Reactivation of fetal gene expression patterns has been implicated in common cardiac diseases in adult life including left ventricular (LV) hypertrophy (LVH) in arterial hypertension.
Grabowski, Katja, Kreutz, Reinhold, Riemenschneider, Mona, Schulte, Leonard, Schulz, Angela, Stoll, Monika, Witten, Anika   +6 more
core   +3 more sources

Risks to human and animal health from the presence of bromide in food and feed

EFSA Journal, Volume 23, Issue 1, January 2025.
Abstract The European Commission mandated EFSA to assess the toxicity of bromide, the existing maximum residue levels (MRLs), and possible transfer from feed into food of animal origin. The critical effects of bromide in experimental animals are on the thyroid and central nervous system.
EFSA Scientific Committee, Susanne Hougaard Bennekou, Ana Allende, Angela Bearth, Josep Casacuberta, Laurence Castle, Tamara Coja, Amélie Crépet, Thorhallur Halldorsson, Laurentius (Ron) Hoogenboom, Helle Knutsen, Konstantinos Koutsoumanis, Claude Lambré, Søren Nielsen, Dominique Turck, Antonio Vicent Civera, Roberto Villa, Holger Zorn, Vasileios Bampidis, Jacqueline Castenmiller, Marie‐Christine Chagnon, Bruce Cottrill, Keyvin Darney, Jürgen Gropp, Secundino Lopez Puente, Martin Rose, Marco Vinceti, Maria Bastaki, Petra Gergelová, Luna Greco, Matteo Lorenzo Innocenti, Judit Janossy, Anna Lanzoni, Andrea Terron, Diane Benford   +34 more
wiley   +1 more source

How age, sex and genotype shape the stress response [PDF]

, 2016
Exposure to chronic stress is a leading pre-disposing factor for several neuropsychiatric disorders as it often leads to maladaptive responses. The response to stressful events is heterogeneous, underpinning a wide spectrum of distinct changes amongst ...
Aisa, Allard, Andersen, Anisman, Anisman, Anisman, Anisman, Ayensu, Baker, Bale, Bangasser, Barbazanges, Barha, Barrientos, Barry, Belzung, Bercik, Bessa, Bielajew, Blaustein, Bohler, Borges, Borges, Boyce, Cannon, Carter, Cerqueira, Chandran, Chattarji, Chen, Chrousos, Clayton, Colich, Crawley, Crumeyrolle-Arias, Dalla, Dalla, Dalla, Dalla, Dalle, Davis, de Kloet, De Kloet, Diamantopoulou, Diamond, Dias-Ferreira, Diaz Brinton, Drossopoulou, Ducottet, Dupouy, Edwards, Ellenbroek, First, Franklin, Gapp, George, Gillies, Glynn, Gold, Gomez, Graham, Griffiths, Gulinello, Gunnar, Hamilton, Harris, Harrison, Hendrick, Holmes, Horovitz, Hua, Huppertz-Kessler, Jacobson, Jacobson-Pick, Jansen, Jernigan, Kapoor, Kitraki, Kokras, Kokras, Lee, Lemaire, Leuner, Li, Lilliecreutz, Liston, Liu, Loria, Lund, Lunghi, Lupien, Lupien, Malki, Marceau, Marona-Lewicka, McCormick, McEwen, McEwen, McEwen, McEwen, Miller, Millstein, Mineur, Mirescu, Mitra, Molet, Monteiro, Morgan, Morilak, Morrison, Nam, Nishio, Nugent, Nyirenda, O'Mahony, Oakley, Oliveira, Oliveira, Oomen, Oomen, Overstreet, Pinos, Power, Prusky, Pucilowski, Rabot, Radley, Rea, Reinisch, Reul, Rice, Rima, Romeo, Romeo, Rondo, Roque, Roque, Roselli, Russo, Sakakura, Sanchez-Hidalgo, Santulli, Sapolsky, Sapolsky, Sapolsky, Sapolsky, Sapolsky, Savignac, Schapiro, Schmidt, Schmitz, Seale, Seale, Seckl, Seckl, Seeman, Selye, Shanks, Shanks, Shanks, Soares, Soares-Cunha, Solberg, Sousa, Sousa, Sousa, Stamatakis, Takuma, Talge, Tauber, Tauber, Taylor, Tikhonova, Toufexis, Treuting, Tsoory, Uchida, Vamvakopoulos, van der Doelen, Ver Hoeve, Viau, Viau, Viau, Vidal, Vyas, Wade, Watanabe, Weiland, Weinstock, Weinstock, Welberg, WHO, Wingfield, Wood, Woods, Workman, Yang, Yuan, Zacharko, Zagron, Zeng, Zhang   +201 more
core   +2 more sources

Re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives

EFSA Journal, Volume 22, Issue 11, November 2024.
Abstract This opinion deals with the re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives. Saccharin is the chemically manufactured compound 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide. Along with its sodium (Na), potassium (K) and calcium (Ca) salts, they are authorised as sweeteners (E 954).
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Monika Batke, Ellen Bruzell, James Chipman, Karlien Cheyns, Riccardo Crebelli, Cristina Fortes, Peter Fürst, Thorhallur Halldorsson, Jean‐Charles LeBlanc, Manuela Mirat, Oliver Lindtner, Alicja Mortensen, Evangelia Ntzani, Romina Shah, Heather Wallace, Matthew Wright, Stefania Barmaz, Consuelo Civitella, Petra Georgelova, Federica Lodi, Elena Mazzoli, Josef Rasinger, Ana Maria Rincon, Alexandra Tard, Panagiota Zakidou, Maged Younes   +42 more
wiley   +1 more source