Influence of Age and Genetic Background on Ethanol Intake and Behavioral Response Following Ethanol Consumption and During Abstinence in a Model of Alcohol Abuse [PDF]
Frontiers in Behavioral Neuroscience, 2022 Genetic background and age at first exposure have been identified as critical variables that contribute to individual vulnerability to drug addiction. Evidence shows that genetic factors may account for 40–70% of the variance in liability to addiction ...
Silvia Corongiu +7 more
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Low-anxiety rat phenotypes can be further reduced through genetic intervention. [PDF]
PLoS ONE, 2013 BACKGROUND: A previous study using an intercross between the inbred rat strains Lewis (LEW) and Spontaneously Hypertensive Rats (SHR) identified a locus on chromosome 4, named Anxrr16, influencing an experimental index of anxiety and showing a ...
Gabriela Ferreira de Medeiros +3 more
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A variable CD3⁺ T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat. [PDF]
PLoS ONE, 2013 PURPOSE: The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM), which arose through a spontaneous mutation within the MHC-congenic inbred strain LEW.1AR1 (RT1(r²)).
Tanja Arndt +6 more
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Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats [PDF]
Functional & Integrative Genomics, 2009 Previously, we identified the regions of chromosomes 10q12-q31 and 15p16-q21 harbor quantitative trait loci (QTLs) for lumbar volumetric bone mineral density (vBMD) in female F2 rats derived from Fischer 344 (F344) x Lewis (LEW) and Copenhagen 2331 (COP) x Dark Agouti (DA) crosses.
Lixiang Liu +7 more
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Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specified-pathogen-free conditions [PDF]
Laboratory Animals, 1987 Four groups of inbred male LEW rats were examined: A, germfree athymic; B, specified pathogen free (SPF) athymic; C, germfree euthymic; D, SPF euthymic. All animals were killed at 18 weeks and compared with respect to body weight, histological appearance and cell density of the lymphoid organs, haematological values and differential counts of bone ...
Klausen, B, Hougen, H P
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N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates ischemia-induced [corrected] acute kidney injury in rat. [PDF]
PLoS ONE, 2012 Since stimulation of transient receptor potential channels of the vanilloid receptor subtype 1 (TRPV1) mitigates acute kidney injury (AKI) and endogenous N-acyl dopamine derivatives are able to activate TRPV1, we tested if synthetic N-octanoyl-dopamine ...
Charalambos Tsagogiorgas +14 more
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Effects of Homozygosity of the nude (rnu) gene in an inbred strain of rats: Studies of lymphoid and non-lymphoid organs in different age groups of nude rats of LEW background at a stage in the gene transfer [PDF]
Laboratory Animals, 1984 Several age groups of nude homozygous rnu/rnu and heterozygous rnu/+ rats of the same genetic background at an early stage of back-crossing (LEW/Mol) were compared as to body and organ weights, histological appearance and cell density of lymphoid organs, haematological values and differential counts of bone marrow and peripheral blood.
Hougen, H P, Klausen, B
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Behavioral and Brain Functions, 2006 Background Attention deficit hyperactivity disorder (ADHD) is a complex neuropsychiatric disorder with a substantial genetic component. The Spontaneously Hypertensive Rats (SHR), considered as a good animal model of ADHD, also show less anxiety-like ...
Ramos André +5 more
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Experimental and Toxicologic Pathology, 1995 Although Lewis rats are frequently used in biomedical research, little is known about their life-data and spontaneous pathology. Therefore, it was the aim of this study to determine the life expectancy, spectrum and incidence of spontaneous neoplasms of the inbred rat strain LEW/Han.
Friedrich Deerberg +3 more
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Frontiers in Neurology, 2015 The rat is the most common animal model for the preclinical validation of neuroprotective therapies in spinal cord injury (SCI). Lipid peroxidation (LP) is a hallmark of the damage triggered after SCI.
Humberto eMestre +8 more
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