A QTL on rat chromosome 7 modulates prepulse inhibition, a neuro-behavioral trait of ADHD, in a Lewis x SHR intercross [PDF]
Behavioral and Brain Functions, 2006 Background Attention deficit hyperactivity disorder (ADHD) is a complex neuropsychiatric disorder with a substantial genetic component. The Spontaneously Hypertensive Rats (SHR), considered as a good animal model of ADHD, also show less anxiety-like ...
Ramos André +5 more
doaj +4 more sources
Influence of Age and Genetic Background on Ethanol Intake and Behavioral Response Following Ethanol Consumption and During Abstinence in a Model of Alcohol Abuse [PDF]
Frontiers in Behavioral Neuroscience, 2022 Genetic background and age at first exposure have been identified as critical variables that contribute to individual vulnerability to drug addiction. Evidence shows that genetic factors may account for 40–70% of the variance in liability to addiction ...
Silvia Corongiu +7 more
doaj +2 more sources
Two inbred rat strains contrasting for anxiety-related behaviors show similar levels of defensive responses to cat odor [PDF]
Behavioral and Brain Functions, 2007 Rodents are known to display fear-related responses when exposed to the odor of natural predators, such as cats, even when they are totally naïve to these stimuli.
Ramos André +2 more
doaj +4 more sources
Neuroimaging reveals distinct brain glucose metabolism patterns associated with morphine consumption in Lewis and Fischer 344 rat strains. [PDF]
Sci Rep, 2022 Vulnerability to addiction may be given by the individual's risk of developing an addiction during their lifetime. A challenge in the neurobiology of drug addiction is understanding why some people become addicted to drugs.
Soto-Montenegro ML +5 more
europepmc +4 more sources
Low-anxiety rat phenotypes can be further reduced through genetic intervention. [PDF]
PLoS ONE, 2013 BACKGROUND: A previous study using an intercross between the inbred rat strains Lewis (LEW) and Spontaneously Hypertensive Rats (SHR) identified a locus on chromosome 4, named Anxrr16, influencing an experimental index of anxiety and showing a ...
Gabriela Ferreira de Medeiros +3 more
doaj +1 more source
A variable CD3⁺ T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat. [PDF]
PLoS ONE, 2013 PURPOSE: The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM), which arose through a spontaneous mutation within the MHC-congenic inbred strain LEW.1AR1 (RT1(r²)).
Tanja Arndt +6 more
doaj +1 more source
Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats [PDF]
Functional & Integrative Genomics, 2009 Previously, we identified the regions of chromosomes 10q12-q31 and 15p16-q21 harbor quantitative trait loci (QTLs) for lumbar volumetric bone mineral density (vBMD) in female F2 rats derived from Fischer 344 (F344) x Lewis (LEW) and Copenhagen 2331 (COP) x Dark Agouti (DA) crosses.
Lixiang Liu +7 more
openaire +3 more sources
N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates ischemia-induced [corrected] acute kidney injury in rat. [PDF]
PLoS ONE, 2012 Since stimulation of transient receptor potential channels of the vanilloid receptor subtype 1 (TRPV1) mitigates acute kidney injury (AKI) and endogenous N-acyl dopamine derivatives are able to activate TRPV1, we tested if synthetic N-octanoyl-dopamine ...
Charalambos Tsagogiorgas +14 more
doaj +1 more source
Predicting Yield Performance of Parents in Plant Breeding: A Neural Collaborative Filtering Approach [PDF]
PLoS ONE 15(5): e0233382 (2020), 2020 Experimental corn hybrids are created in plant breeding programs by crossing two parents, so-called inbred and tester, together. Identification of best parent combinations for crossing is challenging since the total number of possible cross combinations of parents is large and it is impractical to test all possible cross combinations due to limited ...
arxiv +1 more source
Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specified-pathogen-free conditions [PDF]
Laboratory Animals, 1987 Four groups of inbred male LEW rats were examined: A, germfree athymic; B, specified pathogen free (SPF) athymic; C, germfree euthymic; D, SPF euthymic. All animals were killed at 18 weeks and compared with respect to body weight, histological appearance and cell density of the lymphoid organs, haematological values and differential counts of bone ...
Klausen, B, Hougen, H P
openaire +3 more sources