Results 11 to 20 of about 5,907 (142)

Multiple low dose streptozotocin-induced diabetes as a model for studying autoimmune diabetes in humans. [PDF]

Animal Model Exp Med
Multiple low dose streptozotocin‐induced diabetes is a valuable animal model of diabetes type 1. It should be improved by further research on autoantigens, microbiota and mucosal immune cells from the gut, but also from other organs. Abstract The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 ...
Koprivica I, Stanisavljević S, Mićanović D, Stojanović I, Miljković Đ.   +4 more
europepmc   +2 more sources

Contribution of animal models to diabetes research: Its history, significance, and translation to humans. [PDF]

J Diabetes Investig, 2023
Animal models of diabetes and application to human studies ABSTRACT Diabetes mellitus is still expanding globally and is epidemic in developing countries. The combat of this plague has caused enormous economic and social burdens related to a lowered quality of life in people with diabetes.
Yagihashi S.
europepmc   +2 more sources

Artificial intelligence for neurodegenerative experimental models

Alzheimer's &Dementia, Volume 19, Issue 12, Page 5970-5987, December 2023., 2023
Abstract INTRODUCTION Experimental models are essential tools in neurodegenerative disease research. However, the translation of insights and drugs discovered in model systems has proven immensely challenging, marred by high failure rates in human clinical trials.
Sarah J. Marzi, Brian M. Schilder, Alexi Nott, Carlo Sala Frigerio, Sandrine Willaime‐Morawek, Magda Bucholc, Diane P. Hanger, Charlotte James, Patrick A. Lewis, Ilianna Lourida, Wendy Noble, Francisco Rodriguez‐Algarra, Jalil‐Ahmad Sharif, Maria Tsalenchuk, Laura M. Winchester, Ümran Yaman, Zhi Yao, The Deep Dementia Phenotyping (DEMON) Network, Janice M. Ranson, David J. Llewellyn   +19 more
wiley   +1 more source

Faecal metabolite deficit, gut inflammation and diet in Parkinson's disease: Integrative analysis indicates inflammatory response syndrome

Clinical and Translational Medicine, Volume 13, Issue 1, January 2023., 2023
A marker of intestinal inflammation was 44% greater in Parkinson's disease, exceeding a cut‐point for inflammatory bowel disease in 16%. It was associated with a higher maltose and sucrose intake. The emerging picture is of systemic inflammatory response consequent on intestinal inflammation, clinical phenotype being described by deficits in faecal ...
Aisha Augustin, Adrien Le Guennec, Chianna Umamahesan, Aidan Kendler‐Rhodes, Rosalind M. Tucker, Elena Chekmeneva, Panteleimon Takis, Matthew Lewis, Karthik Balasubramanian, Neville DeSouza, Benjamin H Mullish, David Taylor, Suzanne Ryan, Kevin Whelan, Yun Ma, Mohammad A. A. Ibrahim, Ingvar Bjarnason, Bu’ Hussain Hayee, André Charlett, Sylvia M. Dobbs, R. John Dobbs, Clive Weller   +21 more
wiley   +1 more source

Caenorhabditis nematodes colonize ephemeral resource patches in neotropical forests

Ecology and Evolution, Volume 12, Issue 7, July 2022., 2022
Caenorhabditis nematodes are real animals that live in nature. Field collections and experiments in tropical forests reveal new information about their diversity, ecology, behavior, phylogenetics, population biology, and biogeography. Abstract Factors shaping the distribution and abundance of species include life‐history traits, population structure ...
Solomon A. Sloat, Luke M. Noble, Annalise B. Paaby, Max Bernstein, Audrey Chang, Taniya Kaur, John Yuen, Sophia C. Tintori, Jacqueline L. Jackson, Arielle Martel, Jose A. Salome Correa, Lewis Stevens, Karin Kiontke, Mark Blaxter, Matthew V. Rockman   +14 more
wiley   +1 more source

Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways

The Journal of Pathology, Volume 257, Issue 3, Page 300-313, July 2022., 2022
Abstract P2RX7, an ionotropic receptor for extracellular adenosine triphosphate (ATP), is expressed on immune cells, including macrophages, monocytes, and dendritic cells and is upregulated on nonimmune cells following injury. P2RX7 plays a role in many biological processes, including production of proinflammatory cytokines such as interleukin (IL)‐1β ...
Maria Prendecki, Stephen P McAdoo, Tabitha Turner‐Stokes, Ana Garcia‐Diaz, Isabel Orriss, Kevin J Woollard, Jacques Behmoaras, H Terence Cook, Robert Unwin, Charles D Pusey, Timothy J Aitman, Frederick WK Tam   +11 more
wiley   +1 more source

Innate lymphoid cell characterization in the rat and their correlation to gut commensal microbes

European Journal of Immunology, Volume 52, Issue 5, Page 717-729, May 2022., 2022
Rat ILCs are here defined and characterized across multiple tissues, and we have defined the borders between rat NK cells and ILC1s via scRNA‐Seq. Variations of intestinal ILC frequencies in individual rats were mapped against composition of the commensal microbiota. Abstract Innate lymphoid cells (ILCs) are important for tissue immune homeostasis, and
Amanda Sudworth, Filip M. Segers, Bahtiyar Yilmaz, Naomi C. Guslund, Andrew J. Macpherson, Erik Dissen, Shuo‐Wang Qiao, Marit Inngjerdingen   +7 more
wiley   +1 more source

Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans [PDF]

, 2017
Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions ...
Allbutt TC, Bina Joe, Biron P, Biron P, Bright R, Cook HW, Dublin LI, Dublin LI, Dupont J, Esunge PM, Felts JH, Garrod AE, Garrod AE, Garrod AE, Hamilton M, Hamilton M, Hamilton M, Joe B, Koffler M, Korner PI, Kuijpers MH, Lee YH, Lewis O, Markel’ AL, Matsukawa N, Mo R, Ohno Y, Pickering GW, Pravenec M, Sandosh Padmanabhan, Schlager G, Shear CL, Shiozawa M, Smolarek I, Zhang Y   +34 more
core   +1 more source

Lewis, Fischer 344, and Sprague-Dawley rats display differences in lipid peroxidation, motor recovery, and rubrospinal tract preservation after spinal cord injury.

Frontiers in Neurology, 2015
The rat is the most common animal model for the preclinical validation of neuroprotective therapies in spinal cord injury (SCI). Lipid peroxidation (LP) is a hallmark of the damage triggered after SCI.
Humberto eMestre, Manuel eRamirez, Elisa eGarcia, Elisa eGarcia, Susana eMartiñón, Yolanda eCruz, Maria G. Campos, Antonio eIbarra, Antonio eIbarra   +8 more
doaj   +1 more source

Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet

Disease Models & Mechanisms, 2016
Obesity has reached pandemic levels worldwide. The current models of diet-induced obesity in rodents use predominantly high-fat based diets that do not take into account the consumption of variety of highly palatable, energy-dense foods that are ...
Neus Martínez-Micaelo, Noemi González-Abuín, Ximena Terra, Ana Ardévol, Montserrat Pinent, Enrico Petretto, Jacques Behmoaras, Mayte Blay   +7 more
doaj   +1 more source