Results 11 to 20 of about 16,180 (167)
A QTL on rat chromosome 7 modulates prepulse inhibition, a neuro-behavioral trait of ADHD, in a Lewis x SHR intercross [PDF]
Behavioral and Brain Functions, 2006 Background Attention deficit hyperactivity disorder (ADHD) is a complex neuropsychiatric disorder with a substantial genetic component. The Spontaneously Hypertensive Rats (SHR), considered as a good animal model of ADHD, also show less anxiety-like ...
Ramos André +5 more
doaj +4 more sources
Two inbred rat strains contrasting for anxiety-related behaviors show similar levels of defensive responses to cat odor [PDF]
Behavioral and Brain Functions, 2007 Rodents are known to display fear-related responses when exposed to the odor of natural predators, such as cats, even when they are totally naïve to these stimuli.
Ramos André +2 more
doaj +4 more sources
Contribution of animal models to diabetes research: Its history, significance, and translation to humans. [PDF]
J Diabetes Investig, 2023 Animal models of diabetes and application to human studies ABSTRACT Diabetes mellitus is still expanding globally and is epidemic in developing countries. The combat of this plague has caused enormous economic and social burdens related to a lowered quality of life in people with diabetes.
Yagihashi S.
europepmc +2 more sources
Artificial intelligence for neurodegenerative experimental models
Alzheimer's &Dementia, Volume 19, Issue 12, Page 5970-5987, December 2023., 2023 Abstract INTRODUCTION Experimental models are essential tools in neurodegenerative disease research. However, the translation of insights and drugs discovered in model systems has proven immensely challenging, marred by high failure rates in human clinical trials.
Sarah J. Marzi +19 more
wiley +1 more source
Clinical and Translational Medicine, Volume 13, Issue 1, January 2023., 2023 A marker of intestinal inflammation was 44% greater in Parkinson's disease, exceeding a cut‐point for inflammatory bowel disease in 16%. It was associated with a higher maltose and sucrose intake. The emerging picture is of systemic inflammatory response consequent on intestinal inflammation, clinical phenotype being described by deficits in faecal ...
Aisha Augustin +21 more
wiley +1 more source
Experimental rat models of chronic allograft nephropathy: a review [PDF]
, 2014 Chronic allograft nephropathy (CAN) is the leading cause of late allograft loss after renal transplantation (RT), which continues to remain an unresolved problem. A rat model of CAN was first described in 1969 by White et al. Although the rat model of RT
Haylor, John, Shrestha, Badri
core +2 more sources
Caenorhabditis nematodes colonize ephemeral resource patches in neotropical forests
Ecology and Evolution, Volume 12, Issue 7, July 2022., 2022 Caenorhabditis nematodes are real animals that live in nature. Field collections and experiments in tropical forests reveal new information about their diversity, ecology, behavior, phylogenetics, population biology, and biogeography. Abstract Factors shaping the distribution and abundance of species include life‐history traits, population structure ...
Solomon A. Sloat +14 more
wiley +1 more source
The Journal of Pathology, Volume 257, Issue 3, Page 300-313, July 2022., 2022 Abstract P2RX7, an ionotropic receptor for extracellular adenosine triphosphate (ATP), is expressed on immune cells, including macrophages, monocytes, and dendritic cells and is upregulated on nonimmune cells following injury. P2RX7 plays a role in many biological processes, including production of proinflammatory cytokines such as interleukin (IL)‐1β ...
Maria Prendecki +11 more
wiley +1 more source
Journal of Molecular Endocrinology, 2016 Although the effect of genetic background on obesity-related phenotypes is well established, the main objective of this study is to determine the phenotypic responses to cafeteria diet (CAF) of two genetically distinct inbred rat strains and give insight
N. Martínez-Micaelo +6 more
semanticscholar +1 more source
Innate lymphoid cell characterization in the rat and their correlation to gut commensal microbes
European Journal of Immunology, Volume 52, Issue 5, Page 717-729, May 2022., 2022 Rat ILCs are here defined and characterized across multiple tissues, and we have defined the borders between rat NK cells and ILC1s via scRNA‐Seq. Variations of intestinal ILC frequencies in individual rats were mapped against composition of the commensal microbiota. Abstract Innate lymphoid cells (ILCs) are important for tissue immune homeostasis, and
Amanda Sudworth +7 more
wiley +1 more source