Results 11 to 20 of about 5,716 (143)
Multiple low dose streptozotocin-induced diabetes as a model for studying autoimmune diabetes in humans. [PDF]
Animal Model Exp MedMultiple low dose streptozotocin‐induced diabetes is a valuable animal model of diabetes type 1. It should be improved by further research on autoantigens, microbiota and mucosal immune cells from the gut, but also from other organs. Abstract The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 ...
Koprivica I +4 more
europepmc +2 more sources
Contribution of animal models to diabetes research: Its history, significance, and translation to humans. [PDF]
J Diabetes Investig, 2023 Animal models of diabetes and application to human studies ABSTRACT Diabetes mellitus is still expanding globally and is epidemic in developing countries. The combat of this plague has caused enormous economic and social burdens related to a lowered quality of life in people with diabetes.
Yagihashi S.
europepmc +2 more sources
Artificial intelligence for neurodegenerative experimental models
Alzheimer's &Dementia, Volume 19, Issue 12, Page 5970-5987, December 2023., 2023 Abstract INTRODUCTION Experimental models are essential tools in neurodegenerative disease research. However, the translation of insights and drugs discovered in model systems has proven immensely challenging, marred by high failure rates in human clinical trials.
Sarah J. Marzi +19 more
wiley +1 more source
Clinical and Translational Medicine, Volume 13, Issue 1, January 2023., 2023 A marker of intestinal inflammation was 44% greater in Parkinson's disease, exceeding a cut‐point for inflammatory bowel disease in 16%. It was associated with a higher maltose and sucrose intake. The emerging picture is of systemic inflammatory response consequent on intestinal inflammation, clinical phenotype being described by deficits in faecal ...
Aisha Augustin +21 more
wiley +1 more source
Frontiers in Neurology, 2015 The rat is the most common animal model for the preclinical validation of neuroprotective therapies in spinal cord injury (SCI). Lipid peroxidation (LP) is a hallmark of the damage triggered after SCI.
Humberto eMestre +8 more
doaj +1 more source
Experimental and Toxicologic Pathology, 1995 Although Lewis rats are frequently used in biomedical research, little is known about their life-data and spontaneous pathology. Therefore, it was the aim of this study to determine the life expectancy, spectrum and incidence of spontaneous neoplasms of the inbred rat strain LEW/Han.
Baum, Anke +3 more
openaire +2 more sources
Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans [PDF]
, 2017 Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions ...
Allbutt TC +34 more
core +1 more source
Disease Models & Mechanisms, 2016 Obesity has reached pandemic levels worldwide. The current models of diet-induced obesity in rodents use predominantly high-fat based diets that do not take into account the consumption of variety of highly palatable, energy-dense foods that are ...
Neus Martínez-Micaelo +7 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2010 Experimental autoimmune encephalomyelitis (EAE) is mediated by CD4+ Th1 cells that mainly secrete IFN-γ and TNF-α, important cytokines in the pathophysiology of the disease.
Juliana Seger +5 more
doaj +1 more source
Suppression of allograft rejection with FK506: I. prolonged cardiac and liver survival in rats following short-course therapy [PDF]
, 1990 Heterotopic heart and orthotopic liver grafts from ACI donors were transplanted to Lewis rat recipients that were treated with a 3 (or 4) day course of FK506 IM that was started on postoperative day 0, 2, 3, 4, 5, or 6.
Cramer, DV +5 more
core +1 more source