Zinc-finger nuclease mediated disruption of
BMC Immunology, 2012 Background Engineered zinc-finger nucleases (ZFN) represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand breaks (DSB) and initiated non-homologous end joining (NHEJ) after pronuclear or ...
Zschemisch Nils-Holger +6 more
doaj +1 more source
Nest-building behaviour in male rats from three inbred strains: BN/HsdCpb, BDIX/Or1Ico and LEW/Mol
Animal Welfare, 2005 AbstractThree inbred strains of male laboratory rat (BN/HsdCpb, BDIX/Or1Ico and LEW/Mol) were provided with nest boxes and nest materials, and were observed for nest-building activity. After 7 days, each cage and nest box was examined. Each nest was weighed and scored for complexity, and returned to the cage.
IM Jegstrup +3 more
openaire +1 more source
The use of FK-506 for small intestine llotransplantation: Inhibition of acute rejection and prevention of fatal graft-versus-host disease [PDF]
, 1990 Small intestine allotransplantation in humans is not yet feasible due to the failure of the current methods of immunosuppression. FK-506, a powerful new immunosuppressive agent that is synergistic with cyclosporine, allows long-term survival of ...
Banner, B +7 more
core +1 more source
Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundCell damage, tissue and vascular injury are associated with the exposure and release of intracellular components such as RNA, which promote inflammatory reactions and thrombosis. Based on the counteracting anti‐inflammatory and cardioprotective
Eike Kleinert +15 more
doaj +1 more source
Genomics, 2004 We recently identified a single-nucleotide polymorphism in the Ncf1 gene, a component of the NADPH oxidase complex, to be the cause of one of the strongest identified loci for arthritis severity in rats. This polymorphism was found to be naturally occurring in a collection of inbred rat strains as well as in wild rats. Among the inbred strains we found
Peter, Olofsson +6 more
openaire +2 more sources
Modulation of hepatic perfusion did not improve recovery from hepatic outflow obstruction
BMC Pharmacology and Toxicology, 2017 Background Focal hepatic venous outflow obstruction frequently occurs after extended liver resection and leads to a portal hypertension, arterial hypoperfusion and parenchymal necrosis.
J. Arlt +6 more
doaj +1 more source
Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs [PDF]
, 1993 Heterotopic hamster hearts transplanted to unmodified LEW rats underwent humoral rejection in 3 days. Survival was prolonged to a median of 4 days with 2 mg/kg/day FK506.
Cramer, D +6 more
core +1 more source
Induction of donor-specific transplantation tolerance to skin and cardiac allografts using mixed chimerism in (A + B → A) in rats [PDF]
, 1993 Mixed allogeneic chimerism (A + B → A) was induced in rats by reconstitution of lethally irradiated LEW recipients with a mixture of T-cell depleted (TCD) syngeneic and TCD allogeneic ACI bone marrow. Thirty-seven percent of animals repopulated as stable
Cai, X +4 more
core +1 more source
Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts. [PDF]
, 1996 Mycophenolate mofetil (MMF) interacts with purine metabolism and possibly with the expression of adhesion molecules. In the present study, we analysed the expression of these molecules in transplanted kidney allografts treated with RS LBNF1 kidneys were ...
Azuma, H. +5 more
core +1 more source
Fine mapping of bone structure and strength QTLs in heterogeneous stock rat [PDF]
, 2015 We previously demonstrated that skeletal structure and strength phenotypes vary considerably in heterogeneous stock (HS) rats. These phenotypes were found to be strongly heritable, suggesting that the HS rat model represents a unique genetic resource for
Alam, Imranul +16 more
core +1 more source