Results 21 to 30 of about 4,007 (80)
Transfusion, Volume 64, Issue 12, Page 2233-2240, December 2024.Abstract Background The characteristic feature of immune cytopenias involves the process of extravascular phagocytosis, wherein macrophages in the spleen and/or liver engage in the destruction of blood cells that have been opsonized by auto‐ or alloantibodies.
Melika Loriamini +4 more
wiley +1 more source
Journal of Separation Science, Volume 47, Issue 22, November 2024.ABSTRACT Deficiency of cofactors for various enzymes can lead to inborn errors of metabolism. These conditions frequently occur as seizures, which lead to permanent brain damage. Newborn screening for biomarkers associated with these disorders can help in early detection and treatment.
Arya Raveendran +4 more
wiley +1 more source
Re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives
EFSA Journal, Volume 22, Issue 11, November 2024.Abstract This opinion deals with the re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives. Saccharin is the chemically manufactured compound 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide. Along with its sodium (Na), potassium (K) and calcium (Ca) salts, they are authorised as sweeteners (E 954).
EFSA Panel on Food Additives and Flavourings (FAF) +42 more
wiley +1 more source
FASEB BioAdvances, Volume 6, Issue 9, Page 327-336, September 2024.In humans, paragangliomas (PGLs) form in certain neuroendocrine cells that have lost succinate dehydrogenase, an enzyme of the tricarboxylic acid cycle. Conditional SDH deficiency has not yet been shown to drive PGL formation in mice, limiting available research tools. Here, prenatal SDH knockout in small numbers of SOX10+ precursors of adrenal medulla
Elizabeth P. Lewis +7 more
wiley +1 more source
Aging Cell, Volume 23, Issue 9, September 2024.We tested if the effects of metformin were context specific in skeletal muscle using a rat model (high‐capacity and low‐capacity runners: HCRs/LCRs) with a divide in intrinsic aerobic capacity. Metformin lowered mitochondrial respiration, but a washout of metformin resulted in a doubling of respiratory capacity in HCRs, with no effect in LCRs.
Matthew P. Bubak +14 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 7, Issue 3, Page 297-309, June 2024.Abstract Diabetes mellitus is one of the world's most prevalent and complex metabolic disorders, and it is a rapidly growing global public health issue. It is characterized by hyperglycemia, a condition involving a high blood glucose level brought on by deficiencies in insulin secretion, decreased activity of insulin, or both.
Yasodha Krishna Janapati, Sunil Junapudi
wiley +1 more source
Ecology and Evolution, Volume 14, Issue 5, May 2024.We use experimental evolution to test the effects of demographic and evolutionary rescue in populations of Tribolium castaneum previously adapted to high temperature and kept at small population sizes. We find no evidence of rescue in these populations and discuss the results in the context of conservation intervention.
Rebecca Lewis +4 more
wiley +1 more source
The origin, connectivity, and individual specialization of island wolves after deer extirpation
Ecology and Evolution, Volume 14, Issue 4, April 2024.We applied DNA metabarcoding and SNP genotyping to quantify variation in marine foraging behavior within wolf packs, among sexes, and individuals using 957 scats collected from an island and the adjacent mainland from 2016 to 2022. Island wolves consistently consumed sea otters while mainland wolves fed mainly on ungulates and voles with more variation
Charlotte E. Eriksson +4 more
wiley +1 more source
Ecological Monographs, Volume 94, Issue 1, February 2024.Abstract Species turnover with elevation is a widespread phenomenon and provides valuable information on why and how ecological communities might reorganize as the climate warms. It is commonly assumed that species interactions are more likely to set warm range limits, while physiological tolerances determine cold range limits.
Jinlin Chen, Owen T. Lewis
wiley +1 more source
Nervous system‐related tropism of SARS‐CoV‐2 and autoimmunity in COVID‐19 infection
European Journal of Immunology, Volume 54, Issue 1, January 2024.This review summarizes the current knowledge regarding neurotropism and emerging immune responses in SARS‐CoV‐2 infection. There are direct and indirect effects on the nervous system by SARS‐CoV‐2 infection. Presently, vaccination against SARS‐CoV‐2 is the most effective way of preventing SARS‐CoV‐2 infection of the nervous system. Abstract The effects
Robert Weissert
wiley +1 more source